Journal ArticleDOI
The immune system and kidney disease: basic concepts and clinical implications
Reads0
Chats0
TLDR
The kidneys are frequently targeted by pathogenic immune responses against renal autoantigens or by local manifestations of systemic autoimmunity, causing intestinal barrier dysfunction, systemic inflammation and immunodeficiency that contribute to the morbidity and mortality of patients with kidney disease.Abstract:
The kidneys are frequently targeted by pathogenic immune responses against renal autoantigens or by local manifestations of systemic autoimmunity. Recent studies in rodent models and humans have uncovered several underlying mechanisms that can be used to explain the previously enigmatic immunopathology of many kidney diseases. These mechanisms include kidney-specific damage-associated molecular patterns that cause sterile inflammation, the crosstalk between renal dendritic cells and T cells, the development of kidney-targeting autoantibodies and molecular mimicry with microbial pathogens. Conversely, kidney failure affects general immunity, causing intestinal barrier dysfunction, systemic inflammation and immunodeficiency that contribute to the morbidity and mortality of patients with kidney disease. In this Review, we summarize the recent findings regarding the interactions between the kidneys and the immune system.read more
Citations
More filters
Immune cells in experimental acute
TL;DR: Experimental studies of immune cells in AKI have resulted in improved understanding of the immune mechanisms underlying AKI and will be the foundation for development of novel diagnostic and therapeutic targets.
Journal ArticleDOI
Understanding the Current Landscape of Kidney Disease in Canada to Advance Precision Medicine Guided Personalized Care
Thomas M. Kitzler,Justin Chun +1 more
TL;DR: In this paper , the authors reviewed the impact of kidney disease in Canada and the priority areas of kidney research that can benefit from patient-oriented, precision medicine research using novel technologies.
Journal ArticleDOI
N6-methyladenosine regulators-related immune genes enable predict graft loss and discriminate T-cell mediate rejection in kidney transplantation biopsies for cause
Qidan Pang,Hong Chen,Hang-yu Wu,Yong Wang,Chang Hyeok An,S Lai,Jia Xu,Rui Wang,Juan Zhou,Hanyu Xiao +9 more
TL;DR: Wang et al. as discussed by the authors explored the potential value of m6A-related immune genes in predicting graft loss and diagnosing T cell mediated rejection (TCMR), as well as the possible role they play in renal graft dysfunction.
Journal ArticleDOI
Generation of an alpaca serum that induces immune-mediated crescentic glomerulonephritis in mice.
Ermanila Dhana,Daniel Klaus,Alexander M.C. Böhner,Florian Schmidt,Sibylle von Vietinghoff,Peter Boor,Sonja Djudjaj,Christian Kurts +7 more
TL;DR: In this article , Alpaca readily produces ample amounts of antisera that induces pathology in mice, resembling human disease regarding crescent formation, proteinuria, infiltrating immune cells and a significant Th1, but not Th17 immune response.
Book ChapterDOI
Acute Kidney Injury and Cytokines
TL;DR: It is shown that AKI induces the secretion of midkine (MK) and CD147/basigin, which are responsible for skewed cytokine production, which disrupts the reciprocal relationship for regulating tissue repair and remodeling due to amplification of a physiological vicious loop.
References
More filters
Journal ArticleDOI
The Classification of Glomerulonephritis in Systemic Lupus Erythematosus Revisited
Jan J. Weening,Vivette D. D'Agati,Melvin M. Schwartz,Surya V. Seshan,Charles E. Alpers,Gerald B. Appel,James E. Balow,Jan A. Bruijn,Terence Cook,Franco Ferrario,Agnes B. Fogo,Ellen M. Ginzler,Lee A. Hebert,Gary Hill,Prue Hill,J. Charles Jennette,Norella C T Kong,Philippe Lesavre,Michael D. Lockshin,Lai-Meng Looi,Hirofumi Makino,Luiz Antonio Ribeiro de Moura,Michio Nagata +22 more
TL;DR: The main advantages of the current revised classification is that it provides a clear and unequivocal description of the various lesions and classes of lupus nephritis, allowing a better standardization and lending a basis for further clinicopathologic studies.
Journal ArticleDOI
M-type phospholipase A2 receptor as target antigen in idiopathic membranous nephropathy.
Laurence H. Beck,Ramon G. Bonegio,Gérard Lambeau,David M. Beck,David W. Powell,Timothy D. Cummins,Jon B. Klein,David J. Salant +7 more
TL;DR: A majority of patients with idiopathic membranous nephropathy have antibodies against a conformation-dependent epitope in PLA(2)R, indicating that PLA( 2)R is a major antigen in this disease.
Journal ArticleDOI
Cellular pathophysiology of ischemic acute kidney injury
Joseph V. Bonventre,Li Yang +1 more
TL;DR: The major components of this dynamic process, which involves hemodynamic alterations, inflammation, and endothelial and epithelial cell injury, followed by repair that can be adaptive and restore epithelial integrity or maladaptive, leading to chronic kidney disease are reviewed.
Journal ArticleDOI
von Willebrand Factor–Cleaving Protease in Thrombotic Thrombocytopenic Purpura and the Hemolytic–Uremic Syndrome
Miha Furlan,Rodolfo Robles,Miriam Galbusera,Giuseppe Remuzzi,Paul A. Kyrle,Brigitte Brenner,Manuela Krause,Inge Scharrer,Volker Aumann,Uwe Mittler,Max Solenthaler,Bernhard Lämmle +11 more
TL;DR: In this article, the authors investigated the prevalence of von Willebrand factor-cleaving protease deficiency in patients with familial and non-familial forms of thrombocytopenic purpura and hemolytic-uremic syndrome.
Journal ArticleDOI
Netting neutrophils in autoimmune small-vessel vasculitis.
Kai Kessenbrock,Markus Krumbholz,Ulf Schönermarck,Walter Back,Wolfgang Gross,Zena Werb,Hermann-Josef Gröne,Volker Brinkmann,Dieter E. Jenne +8 more
TL;DR: It is shown that chromatin fibers, so-called neutrophil extracellular traps (NETs), are released by ANCA-stimulated neutrophils and contain the targeted autoantigens proteinase-3 and myeloperoxidase (MPO).