Journal ArticleDOI
The immune system and kidney disease: basic concepts and clinical implications
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TLDR
The kidneys are frequently targeted by pathogenic immune responses against renal autoantigens or by local manifestations of systemic autoimmunity, causing intestinal barrier dysfunction, systemic inflammation and immunodeficiency that contribute to the morbidity and mortality of patients with kidney disease.Abstract:
The kidneys are frequently targeted by pathogenic immune responses against renal autoantigens or by local manifestations of systemic autoimmunity. Recent studies in rodent models and humans have uncovered several underlying mechanisms that can be used to explain the previously enigmatic immunopathology of many kidney diseases. These mechanisms include kidney-specific damage-associated molecular patterns that cause sterile inflammation, the crosstalk between renal dendritic cells and T cells, the development of kidney-targeting autoantibodies and molecular mimicry with microbial pathogens. Conversely, kidney failure affects general immunity, causing intestinal barrier dysfunction, systemic inflammation and immunodeficiency that contribute to the morbidity and mortality of patients with kidney disease. In this Review, we summarize the recent findings regarding the interactions between the kidneys and the immune system.read more
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Official American Thoracic Society/Centers for Disease Control and Prevention/Infectious Diseases Society of America Clinical Practice Guidelines: Treatment of Drug-Susceptible Tuberculosis.
Payam Nahid,Susan E. Dorman,Narges Alipanah,Pennan M. Barry,Jan Brozek,Adithya Cattamanchi,Lelia H. Chaisson,Richard E. Chaisson,Charles L. Daley,M. Grzemska,Julie Higashi,Christine S Ho,Philip C. Hopewell,Salmaan Keshavjee,Christian Lienhardt,Richard Menzies,Cynthia Merrifield,Masahiro Narita,Rick O'Brien,Charles A. Peloquin,Ann Raftery,Jussi J. Saukkonen,H. Simon Schaaf,Giovanni Sotgiu,Jeffrey R. Starke,Giovanni Battista Migliori,Andrew Vernon +26 more
TL;DR: This guideline provides recommendations on the clinical and public health management of tuberculosis in children and adults in settings in which mycobacterial cultures, molecular and phenotypic drug susceptibility tests, and radiographic studies, among other diagnostic tools, are available on a routine basis.
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Inflammation in AKI: Current Understanding, Key Questions, and Knowledge Gaps
Hamid Rabb,Matthew D. Griffin,Dianne B. McKay,Sundararaman Swaminathan,Peter Pickkers,Mitchell H. Rosner,John A. Kellum,Claudio Ronco +7 more
TL;DR: The most important recent developments in understanding the inflammatory mechanisms of AKI are summarized, key limitations of the commonly used animal models and clinical trial designs that may prevent successful clinical application are highlighted, and priority approaches for research toward clinical translation are suggested.
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Complement in disease: a defence system turning offensive
TL;DR: This Review summarizes the current view of the key activating, regulatory, and effector mechanisms of the complement system, highlighting important crosstalk connections, and discusses the involvement of complement in clinical conditions and promising therapeutic approaches.
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Immune cells in experimental acute kidney injury
Hye Ryoun Jang,Hamid Rabb +1 more
TL;DR: Experimental studies of immune cells in AKI have resulted in improved understanding of the immune mechanisms underlying AKI and will be the foundation for development of novel diagnostic and therapeutic targets.
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Organ and tissue fibrosis: Molecular signals, cellular mechanisms and translational implications
TL;DR: Specific mechanistic principles of fibrosis regression involve the resolution of chronic tissue injury, the shift of inflammatory processes towards recovery, deactivation of myofibroblasts and finally fibrolysis of excess matrix scaffold.
References
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Podocytes Are Nonhematopoietic Professional Antigen-Presenting Cells
Andreas Goldwich,Miriam Burkard,Martha Ölke,Christoph Daniel,Kerstin Amann,Christian Hugo,Christian Kurts,Alexander Steinkasserer,André Gessner +8 more
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Circulating CSF-1 Promotes Monocyte and Macrophage Phenotypes that Enhance Lupus Nephritis
Julia Menke,Whitney Rabacal,Katelyn T. Byrne,Yasunori Iwata,Melvin M. Schwartz,E. Richard Stanley,Andreas Schwarting,Vicki Rubin Kelley +7 more
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Journal ArticleDOI
Exclusive CX3CR1 dependence of kidney DCs impacts glomerulonephritis progression
Katharina Hochheiser,Christoph Heuser,Torsten A. Krause,Simon Alexander Teteris,Anissa Ilias,Christina Weisheit,Florian Hoss,André P. Tittel,Percy A. Knolle,Ulf Panzer,Daniel R. Engel,Pierre-Louis Tharaux,Christian Kurts +12 more
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Journal ArticleDOI
Chemokine Receptor CXCR3 Mediates T Cell Recruitment and Tissue Injury in Nephrotoxic Nephritis in Mice
Ulf Panzer,Oliver M. Steinmetz,Hans-Joachim Paust,Catherine Meyer-Schwesinger,Anett Peters,Jan-Eric Turner,Gunther Zahner,Felix Heymann,Christian Kurts,Helmut Hopfer,Udo Helmchen,Friedrich Haag,André Schneider,Rolf A.K. Stahl +13 more
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