Journal ArticleDOI
The immune system and kidney disease: basic concepts and clinical implications
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TLDR
The kidneys are frequently targeted by pathogenic immune responses against renal autoantigens or by local manifestations of systemic autoimmunity, causing intestinal barrier dysfunction, systemic inflammation and immunodeficiency that contribute to the morbidity and mortality of patients with kidney disease.Abstract:
The kidneys are frequently targeted by pathogenic immune responses against renal autoantigens or by local manifestations of systemic autoimmunity. Recent studies in rodent models and humans have uncovered several underlying mechanisms that can be used to explain the previously enigmatic immunopathology of many kidney diseases. These mechanisms include kidney-specific damage-associated molecular patterns that cause sterile inflammation, the crosstalk between renal dendritic cells and T cells, the development of kidney-targeting autoantibodies and molecular mimicry with microbial pathogens. Conversely, kidney failure affects general immunity, causing intestinal barrier dysfunction, systemic inflammation and immunodeficiency that contribute to the morbidity and mortality of patients with kidney disease. In this Review, we summarize the recent findings regarding the interactions between the kidneys and the immune system.read more
Citations
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Should We Change the Initial Treatment of Renal or Retroperitoneal Abscess in High Risk Patients
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Modulation of Macrophage Polarization by Human Glomerular Mesangial Cells in Response to the Stimuli in Renal Microenvironment.
Wu-Qiong Liao,Wu-Qiong Liao,Shaoyuan Cui,Qing Ouyang,Yan Mei,Guangyan Cai,Bo Fu,Qian Ma,Xueyuan Bai,Qinggang Li,Xiangmei Chen +10 more
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Conventional NK Cells and Type 1 Innate Lymphoid Cells Do Not Influence Pathogenesis of Experimental Glomerulonephritis
Constantin Rickassel,Ann-Christin Gnirck,Nikhat Naaz Aslam Shaikh,Virginia Adamiak,Alex Waterhölter,Yakup Tanriver,Katrin Neumann,Tobias B. Huber,Georg Gasteiger,Ulf Panzer,Jan-Eric Turner +10 more
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References
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Journal ArticleDOI
Cellular pathophysiology of ischemic acute kidney injury
Joseph V. Bonventre,Li Yang +1 more
TL;DR: The major components of this dynamic process, which involves hemodynamic alterations, inflammation, and endothelial and epithelial cell injury, followed by repair that can be adaptive and restore epithelial integrity or maladaptive, leading to chronic kidney disease are reviewed.
Journal ArticleDOI
von Willebrand Factor–Cleaving Protease in Thrombotic Thrombocytopenic Purpura and the Hemolytic–Uremic Syndrome
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Journal ArticleDOI
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