Journal ArticleDOI
The immune system and kidney disease: basic concepts and clinical implications
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TLDR
The kidneys are frequently targeted by pathogenic immune responses against renal autoantigens or by local manifestations of systemic autoimmunity, causing intestinal barrier dysfunction, systemic inflammation and immunodeficiency that contribute to the morbidity and mortality of patients with kidney disease.Abstract:
The kidneys are frequently targeted by pathogenic immune responses against renal autoantigens or by local manifestations of systemic autoimmunity. Recent studies in rodent models and humans have uncovered several underlying mechanisms that can be used to explain the previously enigmatic immunopathology of many kidney diseases. These mechanisms include kidney-specific damage-associated molecular patterns that cause sterile inflammation, the crosstalk between renal dendritic cells and T cells, the development of kidney-targeting autoantibodies and molecular mimicry with microbial pathogens. Conversely, kidney failure affects general immunity, causing intestinal barrier dysfunction, systemic inflammation and immunodeficiency that contribute to the morbidity and mortality of patients with kidney disease. In this Review, we summarize the recent findings regarding the interactions between the kidneys and the immune system.read more
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Dissertation
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Association between renal failure and red blood cell alloimmunization among newly transfused patients
Josine A. Oud,Dorothea Evers,Rutger A. Middelburg,Karen M.K. de Vooght,Daan van de Kerkhof,Otto Visser,Nathalie C. V. Péquériaux,Francisca Hudig,Johanna G. van der Bom,Jaap Jan Zwaginga +9 more
TL;DR: Renal failure and renal replacement therapy affect the immune system and could therefore modulate red blood cell (RBC) alloimmunization after transfusion.
References
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Journal ArticleDOI
von Willebrand Factor–Cleaving Protease in Thrombotic Thrombocytopenic Purpura and the Hemolytic–Uremic Syndrome
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