Journal ArticleDOI
The immune system and kidney disease: basic concepts and clinical implications
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TLDR
The kidneys are frequently targeted by pathogenic immune responses against renal autoantigens or by local manifestations of systemic autoimmunity, causing intestinal barrier dysfunction, systemic inflammation and immunodeficiency that contribute to the morbidity and mortality of patients with kidney disease.Abstract:
The kidneys are frequently targeted by pathogenic immune responses against renal autoantigens or by local manifestations of systemic autoimmunity. Recent studies in rodent models and humans have uncovered several underlying mechanisms that can be used to explain the previously enigmatic immunopathology of many kidney diseases. These mechanisms include kidney-specific damage-associated molecular patterns that cause sterile inflammation, the crosstalk between renal dendritic cells and T cells, the development of kidney-targeting autoantibodies and molecular mimicry with microbial pathogens. Conversely, kidney failure affects general immunity, causing intestinal barrier dysfunction, systemic inflammation and immunodeficiency that contribute to the morbidity and mortality of patients with kidney disease. In this Review, we summarize the recent findings regarding the interactions between the kidneys and the immune system.read more
Citations
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Journal ArticleDOI
Curcumin and vitamin C improve immunity of kidney via gene expression against diethyl nitrosamine induced nephrotoxicity in rats:In vivo and molecular docking studies
Ahmed B.M. Mehany,Islam M. Farrag,Mahmoud Diab,Mohamed M. Ghoneim,Mohamed El-Sherbiny,Rasha H Al-Serwi,A. Amin,Amany Belal,Salwa Shaaban,Alsayed A. Abdelhady +9 more
TL;DR: In this article , the role of vitamin C and curcumin in targeting immune response proteins was investigated and the results showed that vitamin C has good effects in the treatment of impaired kidneys, this was also observed in renal function and oxidative stress parameters, expression levels of proteins and histopathological examinations.
Journal ArticleDOI
Glucocorticoids target the CXCL9/CXCL10-CXCR3 axis and confer protection against immune-mediated kidney injury
Jan-Hendrik Riedel,Lennart Robben,Hans-Joachim Paust,Yu Zhao,Nariaki Asada,Ning Song,Anett Peters,Anna Kaffke,Alina Borchers,Gisa Tiegs,Larissa Seifert,Nicola M. Tomas,Elion Hoxha,Ulrich Wenzel,Tobias B. Huber,Thorsten Wiech,Jan-Eric Turner,Christian Krebs,Ulf Panzer +18 more
TL;DR: In this article , high-dose steroid treatment rapidly reduced the number of proinflammatory CXCR3+CD4+ T cells in the kidney by combining high-dimensional single-cell and morphological analyses of kidney biopsies from patients with antineutrophil cytoplasmic antibody-associated (ANCA-associated) crescentic glomerulonephritis.
Book ChapterDOI
Molecular Biology of Vitamin D: Genomic and Nongenomic Actions of Vitamin D in Chronic Kidney Disease
TL;DR: This chapter is an update of the progress of the last 5 years in the understanding of the molecular pathophysiology underlying CKD-induced abnormalities in systemic and local vitamin D bioactivation to its hormonal form, 1,25-dihydroxyvitamin D or calcitriol.
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Indoleamine 2,3 Dioxygenase 1—The Potential Link between the Innate Immunity and the Ischemia-Reperfusion-Induced Acute Kidney Injury?
TL;DR: The current review attempts to present a possible role of IDO1 activation in the regulation of the innate immune system in IRI-induced AKI.
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Renal Function: Guardian of Immune Homeostasis.
TL;DR: A key role for renal function in the clearance of circulating Lys-type peptidoglycan is identified, revealing a mechanism that keeps these inflammatory triggers in check to maintain systemic immune homeostasis.
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