Journal ArticleDOI
The immune system and kidney disease: basic concepts and clinical implications
Reads0
Chats0
TLDR
The kidneys are frequently targeted by pathogenic immune responses against renal autoantigens or by local manifestations of systemic autoimmunity, causing intestinal barrier dysfunction, systemic inflammation and immunodeficiency that contribute to the morbidity and mortality of patients with kidney disease.Abstract:
The kidneys are frequently targeted by pathogenic immune responses against renal autoantigens or by local manifestations of systemic autoimmunity. Recent studies in rodent models and humans have uncovered several underlying mechanisms that can be used to explain the previously enigmatic immunopathology of many kidney diseases. These mechanisms include kidney-specific damage-associated molecular patterns that cause sterile inflammation, the crosstalk between renal dendritic cells and T cells, the development of kidney-targeting autoantibodies and molecular mimicry with microbial pathogens. Conversely, kidney failure affects general immunity, causing intestinal barrier dysfunction, systemic inflammation and immunodeficiency that contribute to the morbidity and mortality of patients with kidney disease. In this Review, we summarize the recent findings regarding the interactions between the kidneys and the immune system.read more
Citations
More filters
Journal ArticleDOI
Research Progress on the Potential Mechanisms of Acute Kidney Injury and Chronic Kidney Disease Induced by Proton Pump Inhibitors
Z. H. Song,Xue-Mei Gong +1 more
TL;DR: In this paper , the potential mechanisms by which Proton pump inhibitors (PPIs) cause acute kidney injury (AKI) and chronic kidney disease (CKD) were reviewed.
Journal ArticleDOI
Self‐Assembled L‐DNA Linkers for Rapid Construction of Multi‐Specific Antibody‐Drug Conjugates Library
TL;DR: In this article , a self-assembled left-handed DNA (L-DNA) oligonucleotides are used to link combinatory single-domain antibodies and toxin payloads for tunable and adaptive delivery of ADCs.
Dissertation
The functional characterisation of human innate lymphocytes in renal fibrosis and chronic kidney disease
TL;DR: Various human immune cells of the innate immune system as critical drivers of chronic kidney disease are identified and sheds light on novel functions of innate immune cells and opens opportunities for the development of novel kidney therapies.
OtherDOI
Kidney Lymphatics.
TL;DR: A comprehensive overview of recent and more established research findings on kidney lymphatics and the implications of these findings for kidney function and disease is provided in this article , where a new era of lymphatic-targeted therapies for kidney disease is proposed.
Journal ArticleDOI
Levels of Soluble NKG2D Ligands and Cancer History in Patients Starting Hemodialysis
Kei Nagai,Takashi Tawara,Joichi Usui,Itaru Ebihara,Takashi Ishizu,Masaki Kobayashi,Yoshitaka Maeda,Hiroaki Kobayashi,Kunihiro Yamagata +8 more
TL;DR: The significance of cancer in patients starting hemodialysis was elucidated for the first time and Elevated levels of soluble NKG2D ligands occurred potentially due to complex mechanisms of oxidative stress, with insufficient metabolism and excretion in a uremic milieu, but they might mask the significance of elevations in serum levels ofNKG2DLs in patients with a cancer history.
References
More filters
Journal ArticleDOI
The Classification of Glomerulonephritis in Systemic Lupus Erythematosus Revisited
Jan J. Weening,Vivette D. D'Agati,Melvin M. Schwartz,Surya V. Seshan,Charles E. Alpers,Gerald B. Appel,James E. Balow,Jan A. Bruijn,Terence Cook,Franco Ferrario,Agnes B. Fogo,Ellen M. Ginzler,Lee A. Hebert,Gary Hill,Prue Hill,J. Charles Jennette,Norella C T Kong,Philippe Lesavre,Michael D. Lockshin,Lai-Meng Looi,Hirofumi Makino,Luiz Antonio Ribeiro de Moura,Michio Nagata +22 more
TL;DR: The main advantages of the current revised classification is that it provides a clear and unequivocal description of the various lesions and classes of lupus nephritis, allowing a better standardization and lending a basis for further clinicopathologic studies.
Journal ArticleDOI
M-type phospholipase A2 receptor as target antigen in idiopathic membranous nephropathy.
Laurence H. Beck,Ramon G. Bonegio,Gérard Lambeau,David M. Beck,David W. Powell,Timothy D. Cummins,Jon B. Klein,David J. Salant +7 more
TL;DR: A majority of patients with idiopathic membranous nephropathy have antibodies against a conformation-dependent epitope in PLA(2)R, indicating that PLA( 2)R is a major antigen in this disease.
Journal ArticleDOI
Cellular pathophysiology of ischemic acute kidney injury
Joseph V. Bonventre,Li Yang +1 more
TL;DR: The major components of this dynamic process, which involves hemodynamic alterations, inflammation, and endothelial and epithelial cell injury, followed by repair that can be adaptive and restore epithelial integrity or maladaptive, leading to chronic kidney disease are reviewed.
Journal ArticleDOI
von Willebrand Factor–Cleaving Protease in Thrombotic Thrombocytopenic Purpura and the Hemolytic–Uremic Syndrome
Miha Furlan,Rodolfo Robles,Miriam Galbusera,Giuseppe Remuzzi,Paul A. Kyrle,Brigitte Brenner,Manuela Krause,Inge Scharrer,Volker Aumann,Uwe Mittler,Max Solenthaler,Bernhard Lämmle +11 more
TL;DR: In this article, the authors investigated the prevalence of von Willebrand factor-cleaving protease deficiency in patients with familial and non-familial forms of thrombocytopenic purpura and hemolytic-uremic syndrome.
Journal ArticleDOI
Netting neutrophils in autoimmune small-vessel vasculitis.
Kai Kessenbrock,Markus Krumbholz,Ulf Schönermarck,Walter Back,Wolfgang Gross,Zena Werb,Hermann-Josef Gröne,Volker Brinkmann,Dieter E. Jenne +8 more
TL;DR: It is shown that chromatin fibers, so-called neutrophil extracellular traps (NETs), are released by ANCA-stimulated neutrophils and contain the targeted autoantigens proteinase-3 and myeloperoxidase (MPO).