Journal ArticleDOI
The immune system and kidney disease: basic concepts and clinical implications
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TLDR
The kidneys are frequently targeted by pathogenic immune responses against renal autoantigens or by local manifestations of systemic autoimmunity, causing intestinal barrier dysfunction, systemic inflammation and immunodeficiency that contribute to the morbidity and mortality of patients with kidney disease.Abstract:
The kidneys are frequently targeted by pathogenic immune responses against renal autoantigens or by local manifestations of systemic autoimmunity. Recent studies in rodent models and humans have uncovered several underlying mechanisms that can be used to explain the previously enigmatic immunopathology of many kidney diseases. These mechanisms include kidney-specific damage-associated molecular patterns that cause sterile inflammation, the crosstalk between renal dendritic cells and T cells, the development of kidney-targeting autoantibodies and molecular mimicry with microbial pathogens. Conversely, kidney failure affects general immunity, causing intestinal barrier dysfunction, systemic inflammation and immunodeficiency that contribute to the morbidity and mortality of patients with kidney disease. In this Review, we summarize the recent findings regarding the interactions between the kidneys and the immune system.read more
Citations
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Journal ArticleDOI
Innate And Adaptive Immunity are Progressively Activated in Parallel with Renal Injury in the 5/6 Renal Ablation Model
Camilla Fanelli,Simone Costa Alarcon Arias,Flavia Gomes Machado,Jessica Kazumi Okuma,Denise Maria Avancini Costa Malheiros,Hatylas Azevedo,Carlos Alberto Moreira-Filho,Niels Olsen Saraiva Camara,Clarice Kazue Fujihara,Roberto Zatz +9 more
TL;DR: Observations indicate that parallel activation of innate and adaptive immunity antecedes glomerular injury and involves a growing number of intricate signaling pathways, helping to explain the difficulty in detaining renal injury in Nx as CKD advances, and, stressing the need for early treatment.
Journal ArticleDOI
IL-17 in Renal Immunity and Autoimmunity
TL;DR: The current knowledge of IL-17 activity in the kidney is discussed in context to renal immunity and autoimmunity and the intriguing question to what extent neutralization ofIL-17 is beneficial or harmful to renal inflammation is raised.
Journal ArticleDOI
Acute Kidney Injury is Aggravated in Aged Mice by the Exacerbation of Proinflammatory Processes.
Laura Marquez-Exposito,Lucia Tejedor-Santamaria,Laura Santos-Sanchez,Floris A. Valentijn,Elena Cantero-Navarro,Sandra Rayego-Mateos,Raúl R. Rodrigues-Diez,Antonio Tejera-Muñoz,Vanessa Marchant,Ana Belen Sanz,Alberto Ortiz,Roel Goldschmeding,Marta Ruiz-Ortega +12 more
TL;DR: In this paper, experimental AKI was induced by folic acid (FA) administration in young (3-months old) and old (1-year old) mice, and kidneys were evaluated in the early phase of AKI, at 48 h.
Journal ArticleDOI
B7x/B7-H4 modulates the adaptive immune response and ameliorates renal injury in antibody-mediated nephritis.
Rahul D. Pawar,Beatrice Goilav,Yumin Xia,Leal Herlitz,Jessica Doerner,Samantha A. Chalmers,Kaya Ghosh,Xingxing Zang,Chaim Putterman +8 more
TL;DR: It is proposed that B7x can modulate kidney damage in autoimmune diseases including lupus nephritis and anti‐glomerular basement membrane disease.
Journal ArticleDOI
Proportion and mortality of Iranian diabetes mellitus, chronic kidney disease, hypertension and cardiovascular disease patients with COVID-19: a meta-analysis.
Hamid Mirjalili,Seyed Alireza Dastgheib,Seyed Hossein Shaker,Reza Bahrami,Mahta Mazaheri,Seyed Mohamad Hossein Sadr-Bafghi,Jalal Sadeghizadeh-Yazdi,Hossein Neamatzadeh +7 more
TL;DR: In this paper, a meta-analysis was conducted to estimate the proportion and mortality of SARS-COV-2 infection in Iranian patients with chronic kidney disease (CKD), hypertension and cardiovascular diseases (CVDs).
References
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