The Immunobiology of the Interleukin-12 Family: Room for Discovery.
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TLDR
Significant knowledge gaps are presented, including how similar signals from these cytokines can mediate distinct outcomes, and how a better understanding of the biology of the IL-12 family provides new therapeutic opportunities.About:
This article is published in Immunity.The article was published on 2019-04-16 and is currently open access. It has received 254 citations till now.read more
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Single-Cell Analyses Inform Mechanisms of Myeloid-Targeted Therapies in Colon Cancer.
Lei Zhang,Ziyi Li,Katarzyna M. Skrzypczynska,Qiao Fang,Wei Zhang,Sarah A. O’Brien,Yao He,Lynn Wang,Qiming Zhang,Aeryon Kim,Ranran Gao,Jessica Orf,Tao Wang,Deepali V. Sawant,Jiajinlong Kang,Dev Bhatt,Daniel Lu,Chi-Ming Li,Aaron S. Rapaport,Kristy Perez,Yingjiang Ye,Shan Wang,Xueda Hu,Xianwen Ren,Wenjun Ouyang,Zhanlong Shen,Jackson G. Egen,Zemin Zhang,Xin Yu +28 more
TL;DR: This comprehensive analysis of key myeloid subsets in human and mouse identifies critical cellular interactions regulating tumor immunity and defines mechanisms underlying myeloids-targeted immunotherapies currently undergoing clinical testing.
Journal ArticleDOI
The cytokine network involved in the host immune response to periodontitis
TL;DR: This review begins with an up-to-date aetiological hypothesis of periodontal disease and summarize the roles of cytokines in the host immune response and the latest cytokine-related therapeutic measures for periodontic disease.
Journal ArticleDOI
Interleukins in cancer: from biology to therapy.
Daria Briukhovetska,Janina Dörr,Stefan Endres,Peter Libby,Charles A. Dinarello,Sebastian Kobold +5 more
TL;DR: A review of interleukin-related mechanisms in cancer, together with their application in clinical practice is provided in this paper, which includes an overview of current clinical trials and breakthrough preclinical concepts.
Journal ArticleDOI
Germinal Center and Extrafollicular B Cell Responses in Vaccination, Immunity, and Autoimmunity.
TL;DR: The current understanding of the functional output of EF and GC responses and the molecular switches promoting them are reviewed, the signals that regulate the magnitude and duration of these responses are discussed, and gaps in knowledge are outlined.
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Harnessing cytokines and chemokines for cancer therapy
TL;DR: The lessons learnt from the initial trials of single-agent cytokine-based therapies and subsequent efforts to better exploit such agents for the treatment of solid tumours are discussed.
References
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Journal Article
Two types of murine helper T cell clone. I. Definition according to profiles of lymphokine activities and secreted proteins.
TL;DR: A panel of antigen-specific mouse helper T cell clones was characterized according to patterns of lymphokine activity production, and two types of T cell were distinguished.
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Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells.
Estelle Bettelli,Yijun Carrier,Wenda Gao,Thomas Korn,Terry B. Strom,Mohamed Oukka,Howard L. Weiner,Vijay K. Kuchroo +7 more
TL;DR: It is shown that IL-6, an acute phase protein induced during inflammation, completely inhibits the generation of Foxp3+ Treg cells induced by TGF-β, and the data demonstrate a dichotomy in thegeneration of pathogenic (TH17) T cells that induce autoimmunity and regulatory (Foxp3+) T Cells that inhibit autoimmune tissue injury.
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The phosphoinositide 3-kinase pathway.
TL;DR: The PI3K pathway is implicated in human diseases including diabetes and cancer, and understanding the intricacies of this pathway may provide new avenues for therapuetic intervention.
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IL-23 drives a pathogenic T cell population that induces autoimmune inflammation
Claire L. Langrish,Yi Yi Chen,Wendy M. Blumenschein,Jeanine D. Mattson,Beth Basham,Jonathan D. Sedgwick,Terrill K. McClanahan,Robert A. Kastelein,Daniel J. Cua +8 more
TL;DR: Using passive transfer studies, it is confirmed that these IL-23–dependent CD4+ T cells are highly pathogenic and essential for the establishment of organ-specific inflammation associated with central nervous system autoimmunity.
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TGFβ in the context of an inflammatory cytokine milieu supports de novo differentiation of IL-17-Producing T cells
Marc Veldhoen,Richard J. Hocking,Christopher J. Atkins,Richard M. Locksley,Brigitta Stockinger +4 more
TL;DR: The data indicate that, in the presence of IL-6, TGFbeta1 subverts Th1 and Th2 differentiation for the generation ofIL-17-producing T cells.
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