The molecular biology of coronaviruses
Michael M. C. Lai,David Cavanagh +1 more
TLDR
This chapter discusses the manipulation of clones of coronav virus and of complementary DNAs of defective-interfering RNAs to study coronavirus RNA replication, transcription, recombination, processing and transport of proteins, virion assembly, identification of cell receptors for coronaviruses, and processing of the polymerase.Citations
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Origin and evolution of pathogenic coronaviruses
Jie Cui,Fang Li,Zhengli Shi +2 more
TL;DR: The viral factors that enabled the emergence of diseases such as severe acute respiratory syndrome and Middle East respiratory syndrome are explored and the diversity and potential of bat-borne coronaviruses are highlighted.
Journal ArticleDOI
Epidemiology, Genetic Recombination, and Pathogenesis of Coronaviruses
Shuo Su,Gary Wong,Weifeng Shi,Jun Liu,Jun Liu,Alexander Lai,Jiyong Zhou,Wenjun Liu,Yuhai Bi,George F. Gao +9 more
TL;DR: This review aims to compare and contrast the different HCoVs with regard to epidemiology and pathogenesis, in addition to the virus evolution and recombination events which have, on occasion, resulted in outbreaks amongst humans.
Journal ArticleDOI
The Genome Sequence of the SARS-associated Coronavirus
Marco A. Marra,Steven J.M. Jones,Caroline R. Astell,Robert A. Holt,Angela Brooks-Wilson,Yaron S.N. Butterfield,Jaswinder Khattra,Jennifer Asano,Sarah Barber,Susanna Y. Chan,Alison Cloutier,Shaun M. Coughlin,Doug Freeman,Noreen Girn,Obi L. Griffith,Stephen Leach,Michael Mayo,Helen McDonald,Stephen B. Montgomery,Pawan Pandoh,Anca Petrescu,A. Gordon Robertson,Jacqueline E. Schein,Asim Siddiqui,Duane E. Smailus,Jeff M. Stott,George S. Yang,Francis A. Plummer,Anton Andonov,Harvey Artsob,Nathalie Bastien,Kathy Bernard,Timothy F. Booth,Donnie Bowness,Martin Czub,Michael Drebot,Lisa Fernando,Ramon Flick,Michael Garbutt,Michael Gray,Allen Grolla,Steven M. Jones,Heinz Feldmann,Adrienne Meyers,Amin Kabani,Yan Li,Susan Normand,Ute Ströher,Graham A. Tipples,Shaun Tyler,Robert Vogrig,Diane M. Ward,Brynn Watson,Robert C. Brunham,Mel Krajden,Martin Petric,Danuta M. Skowronski,Chris Upton,Rachel L. Roper +58 more
TL;DR: The genome sequence reveals that the severe acute respiratory syndrome–associated coronavirus known as the Tor2 isolate is only moderately related to other known coronaviruses, andylogenetic analysis of the predicted viral proteins indicates that the virus does not closely resemble any of the three previously known groups of coronavirs.
Book ChapterDOI
The molecular biology of coronaviruses.
TL;DR: This review summarizes both classical and contemporary discoveries in the study of the molecular biology of these infectious agents, with particular emphasis on the nature and recognition of viral receptors, viral RNA synthesis, and the molecular interactions governing virion assembly.
Journal ArticleDOI
Severe acute respiratory syndrome coronavirus-like virus in Chinese horseshoe bats
Susanna K. P. Lau,Patrick C. Y. Woo,Kenneth S. M. Li,Yi Huang,Hoi-Wah Tsoi,Beatrice H.L. Wong,Samson S. Y. Wong,Suet Yi Leung,Kwok-Hung Chan,Kwok-Yung Yuen +9 more
TL;DR: In a surveillance study for CoV in noncaged animals from the wild areas of the Hong Kong Special Administration Region, a CoV closely related to SARS-CoV is identified from 23 (39%) of 59 anal swabs of wild Chinese horseshoe bats by using RT-PCR and the presence of a 29-bp insertion in ORF 8 of bat-SARS- coV genome suggests that it has a common ancestor with civet SARS -CoV.
References
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Book
Diseases of poultry.
TL;DR: In this article, the authors describe symptoms, treatments, and prevention methods for numerous diseases and parasites afflicting poultry, including worms, worms, and parasites, such as worms and worms.
Journal ArticleDOI
Human aminopeptidase N is a receptor for human coronavirus 229E
C L Yeager,Richard A. Ashmun,Richard K. Williams,Christine B. Cardellichio,Linda H. Shapiro,A T Look,A T Look,Kathryn V. Holmes +7 more
TL;DR: It is reported that human aminopeptidase N, a cell-surface metalloprotease on intestinal, lung and kidney epithelial cells, is a receptor for human coronavirus strainHCV-229E, but not for HCV-OC43.
Journal ArticleDOI
Characterization of an efficient coronavirus ribosomal frameshifting signal: requirement for an RNA pseudoknot.
TL;DR: It is shown by creation of complementary nucleotide changes that the RNA downstream of this “slippery” sequence folds into a tertiary structure termed a pseudoknot, the formation of which is essential for efficient frameshifting.
Journal ArticleDOI
RNA recombination in animal and plant viruses.
TL;DR: The high frequency and widespread nature of RNA recombination indicate that this phenomenon plays a more significant role in the biology of RNA viruses than was previously recognized.
Journal ArticleDOI
Aminopeptidase N is a major receptor for the entero-pathogenic coronavirus TGEV.
TL;DR: It is reported that aminopeptidase N, an ectoenzyme abundantly expressed at the apical membrane of the enterocytes, serves as a receptor for Transmissible gastroenteritis virus.
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