Journal ArticleDOI
The regulation of mitochondrial morphology: intricate mechanisms and dynamic machinery.
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TLDR
This review focuses on the current understanding of the mitochondrial morphology machinery in cell homeostasis, apoptosis and neurodegeneration, and the post translational modifications that regulate these processes.About:
This article is published in Cellular Signalling.The article was published on 2011-10-01. It has received 252 citations till now. The article focuses on the topics: mitochondrial fusion & Mitochondrion.read more
Citations
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Mitochondrial rhomboid parl regulates cytochrome c release during apoptosis via OPA1 dependent cristae remodeling
Sara Cipolat,Tomasz Rudka,Dieter H. Hartmann,Costa,S. Serneels,Kathleen Craessaerts,Kristine Metzger,Luca Scorrano,Bart De Strooper +8 more
TL;DR: Parl-associated rhomboid-like (PARL-like) as mentioned in this paper is an inner mitochondrial membrane rhomboids of unknown function, whose yeast ortholog is involved in mitochondrial fusion.
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hFis1, a novel component of the mammalian mitochondrial fission machinery. Vol. 278 (2003) 36373–36379
TL;DR: In this article, the authors identified a mammalian protein called hFis1, which is the orthologue of the yeast Fis1p known to participate in yeast mitochondrial division, and when overexpressed in various cell types, localized to the outer mitochondrial membrane and induced mitochondrial fission.
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Bioenergetic role of mitochondrial fusion and fission.
TL;DR: Fragmented mitochondria are frequently found in resting cells, and mitochondrial fission plays an important role in the removal of damaged organelles by autophagy, which contributes to maintenance of mitochondrial function and optimize bioenergetic capacity.
Journal ArticleDOI
Cellular and molecular mechanisms of mitochondrial function
TL;DR: Mitochondria are membrane bound organelles present in almost all eukaryotic cells and contribute to many processes central to cellular function and dysfunction including calcium signalling, cell growth and differentiation, cell cycle control and cell death.
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Impaired mitochondrial function in psychiatric disorders.
Husseini K. Manji,Tadafumi Kato,Nicholas A. Di Prospero,Seth Ness,M. Flint Beal,Michael Krams,Guang Chen +6 more
TL;DR: There is a growing body of evidence to suggest that impaired mitochondrial function may affect key cellular processes, thereby altering synaptic functioning and contributing to the atrophic changes that underlie the deteriorating long-term course of these illnesses.
References
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Journal ArticleDOI
Inter-mitochondrial complementation: Mitochondria-specific system preventing mice from expression of disease phenotypes by mutant mtDNA
Kazuto Nakada,Kimiko Inoue,Kimiko Inoue,Tomoko Ono,Kotoyo Isobe,Atsuo Ogura,Yu-ichi Goto,Ikuya Nonaka,Jun-Ichi Hayashi +8 more
TL;DR: Inter-mitochondrial complementation shows a mitochondria-specific mechanism for avoiding expression of deletion-mutant mtDNA, and opens the possibility of a gene therapy in which mitochondria possessing full-length DNA are introduced.
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A common lipid links Mfn-mediated mitochondrial fusion and SNARE-regulated exocytosis
TL;DR: The findings reveal that although mitochondrial fusion and regulated exocytic fusion are mediated by distinct sets of protein machinery, the underlying processes are unexpectedly linked by the generation of a common fusogenic lipid.
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Proteolytic processing of OPA1 links mitochondrial dysfunction to alterations in mitochondrial morphology.
Stéphane Duvezin-Caubet,Ravi Jagasia,Johannes Wagener,Sabine Hofmann,Aleksandra Trifunovic,Anna Hansson,Anne Chomyn,Matthias F. Bauer,Giuseppe Attardi,Nils-Göran Larsson,Walter Neupert,Andreas S. Reichert +11 more
TL;DR: The hypothesis that this pathway regulates mitochondrial morphology and serves as an early response to prevent fusion of dysfunctional mitochondria with the functional mitochondrial network is presented.
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The Dynamin-related GTPase, Dnm1p, Controls Mitochondrial Morphology in Yeast
Denichiro Otsuga,Brian R. Keegan,Ellen Brisch,John Thatcher,Greg J. Hermann,William Bleazard,Janet M. Shaw +6 more
TL;DR: It is demonstrated that Dnm1p is required for the cortical distribution of the mitochondrial network in yeast, a novel function for a dynamin-related protein.
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Opa1 deficiency in a mouse model of autosomal dominant optic atrophy impairs mitochondrial morphology, optic nerve structure and visual function
Vanessa J. Davies,Andrew John Hollins,Malgorzata Piechota,Wan Fen Yip,Jennifer R. Davies,Kathryn White,Phillip P. Nicols,Michael E. Boulton,Michael E. Boulton,Marcela Votruba +9 more
TL;DR: Findings indicate that the opa1 GTPase contains crucial information required for the survival of RGCs and that Opa1 is essential for early embryonic survival.