Journal ArticleDOI
The regulation of mitochondrial morphology: intricate mechanisms and dynamic machinery.
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TLDR
This review focuses on the current understanding of the mitochondrial morphology machinery in cell homeostasis, apoptosis and neurodegeneration, and the post translational modifications that regulate these processes.About:
This article is published in Cellular Signalling.The article was published on 2011-10-01. It has received 252 citations till now. The article focuses on the topics: mitochondrial fusion & Mitochondrion.read more
Citations
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Mitochondrial rhomboid parl regulates cytochrome c release during apoptosis via OPA1 dependent cristae remodeling
Sara Cipolat,Tomasz Rudka,Dieter H. Hartmann,Costa,S. Serneels,Kathleen Craessaerts,Kristine Metzger,Luca Scorrano,Bart De Strooper +8 more
TL;DR: Parl-associated rhomboid-like (PARL-like) as mentioned in this paper is an inner mitochondrial membrane rhomboids of unknown function, whose yeast ortholog is involved in mitochondrial fusion.
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hFis1, a novel component of the mammalian mitochondrial fission machinery. Vol. 278 (2003) 36373–36379
TL;DR: In this article, the authors identified a mammalian protein called hFis1, which is the orthologue of the yeast Fis1p known to participate in yeast mitochondrial division, and when overexpressed in various cell types, localized to the outer mitochondrial membrane and induced mitochondrial fission.
Journal ArticleDOI
Bioenergetic role of mitochondrial fusion and fission.
TL;DR: Fragmented mitochondria are frequently found in resting cells, and mitochondrial fission plays an important role in the removal of damaged organelles by autophagy, which contributes to maintenance of mitochondrial function and optimize bioenergetic capacity.
Journal ArticleDOI
Cellular and molecular mechanisms of mitochondrial function
TL;DR: Mitochondria are membrane bound organelles present in almost all eukaryotic cells and contribute to many processes central to cellular function and dysfunction including calcium signalling, cell growth and differentiation, cell cycle control and cell death.
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Impaired mitochondrial function in psychiatric disorders.
Husseini K. Manji,Tadafumi Kato,Nicholas A. Di Prospero,Seth Ness,M. Flint Beal,Michael Krams,Guang Chen +6 more
TL;DR: There is a growing body of evidence to suggest that impaired mitochondrial function may affect key cellular processes, thereby altering synaptic functioning and contributing to the atrophic changes that underlie the deteriorating long-term course of these illnesses.
References
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Journal ArticleDOI
CaM kinase Iα–induced phosphorylation of Drp1 regulates mitochondrial morphology
Xiao Jian Han,Yun Fei Lu,Shun Ai Li,Taku Kaitsuka,Yasufumi Sato,Kazuhito Tomizawa,Angus C. Nairn,Kohji Takei,Hideki Matsui,Masayuki Matsushita +9 more
TL;DR: Ca2+ is likely to be functionally important in the control of mitochondrial dynamics through regulation of Drp1 phosphorylation in neurons and other cell types, suggesting that CaMKIα is a widely expressed protein kinase.
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Preventing mitochondrial fission impairs mitochondrial function and leads to loss of mitochondrial DNA.
Philippe A. Parone,Sandrine Da Cruz,Daniel Tondera,Yves Benoît Mattenberger,Dominic I. James,Pierre Maechler,François Barja,Jean-Claude Martinou +7 more
TL;DR: It is proposed that mitochondrial fission is required for preservation of mitochondrial function and thereby for maintenance of cellular homeostasis.
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Mitofusin-1 protein is a generally expressed mediator of mitochondrial fusion in mammalian cells
Ansgar Santel,Stephan Frank,Stephan Frank,Brigitte Gaume,Michael Herrler,Richard J. Youle,Margaret T. Fuller +6 more
TL;DR: Mfn1 appears to be a key player in mediating mitochondrial fusion and morphology in mammalian cells by binding necessary cofactors and interferes with fusion activity of endogenous Mfn1 protein to allow unopposed mitochondrial fission.
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Ganglioside-induced differentiation associated protein 1 is a regulator of the mitochondrial network: new implications for Charcot-Marie-Tooth disease
TL;DR: The data indicate that an exquisitely tight control of mitochondrial dynamics, regulated by GDAP1, is crucial for the proper function of myelinated peripheral nerves.
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Membrane Remodeling Induced by the Dynamin-Related Protein Drp1 Stimulates Bax Oligomerization
Sylvie Montessuit,Syam Prakash Somasekharan,Oihana Terrones,Safa Lucken-Ardjomande,Sébastien Herzig,Robert Schwarzenbacher,Dietmar J. Manstein,Ella Bossy-Wetzel,Gorka Basañez,Paolo Meda,Jean-Claude Martinou +10 more
TL;DR: It is shown that Drp1 stimulates tBid-induced Bax oligomerization and cytochrome c release by promoting tethering and hemifusion of membranes in vitro by exploiting arginine 247 and the presence of cardiolipin in membranes.