Journal ArticleDOI
Viper venom-induced inflammation and inhibition of free radical formation by pure compound (2-hydroxy-4-methoxy benzoic acid) isolated and purified from anantamul (Hemidesmus indicus R.Br) root extract
M.I. Alam,Aparna Gomes +1 more
TLDR
The present investigation explored the possible venom neutralizing effect of a pure compound isolated and purified from the methanolic root extract of Hemidesmus indicus R.Rr.About:
This article is published in Toxicon.The article was published on 1998-01-01. It has received 112 citations till now. The article focuses on the topics: Hemidesmus indicus.read more
Citations
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Journal ArticleDOI
Hemidesmus indicus induces apoptosis as well as differentiation in a human promyelocytic leukemic cell line.
Lorenzo Ferruzzi,Eleonora Turrini,Sabrina Burattini,E. Falcieri,E. Falcieri,Ferruccio Poli,Manuela Mandrone,Gianni Sacchetti,Massimo Tacchini,Alessandra Guerrini,Roberto Gotti,Patrizia Hrelia,Giorgio Cantelli-Forti,Carmela Fimognari +13 more
TL;DR: The cytodifferentiating, cytotoxic and cytostatic activities of Hemidesmus indicus offers a scientific basis for its use in traditional medicine and provides a pre-clinical evidence for its traditional use in anticancer pharmacology.
Journal ArticleDOI
Neutralization of local and systemic toxicity of Daboia russelii venom by Morus alba plant leaf extract.
TL;DR: In this investigation Morus alba plant leaf extract has been studied against the Indian Vipera/Daboia russelii venom induced local and systemic effects and processes potent antisnake venom property.
Journal ArticleDOI
Modulation of biochemical parameters by Hemidesmus indicus in cumene hydroperoxide-induced murine skin: possible role in protection against free radicals-induced cutaneous oxidatve stress and tumor promotion
TL;DR: The data suggest that H. indicus is an effective chemopreventive agent in skin and capable of ameliorating hydroperoxide-induced cutaneous oxidative stress and tumor promotion and phase II metabolizing enzymes were recovered to significant level.
Journal ArticleDOI
Proteomic analysis of the pathophysiological process involved in the antisnake venom effect of Mucuna pruriens extract.
Roberto Guerranti,Ifeanyi G. Ogueli,Erica Bertocci,Chiara Muzzi,John C. Aguiyi,Riccardo Cianti,Alessandro Armini,Luca Bini,Roberto Leoncini,Enrico Marinello,Roberto Pagani +10 more
TL;DR: The mechanism of MPE protection involves the activation of counterbalancing processes to compensate for the imbalances caused by EV, and the plasma of CHALLENGED mice showed substantial proteomic modifications.
Journal ArticleDOI
Protective effect of 2-hydroxy-4-methoxy benzoic acid on testosterone induced benign prostatic hyperplasia in Wister rats.
TL;DR: The present study suggests the protective role of HMBA on testosterone induced BPH by virtue of its antioxidant potential, and significantly restored antioxidant enzyme levels, lipid peroxide and total nitrite when compared to disease control animals.
References
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Superoxide dismutase: Improved assays and an assay applicable to acrylamide gels☆
TL;DR: The staining procedure for localizing superoxide dismutase on polyacrylamide electrophoretograms has been applied to extracts obtained from a variety of sources and could thus be assayed either in crude extracts or in purified protein fractions.
Journal ArticleDOI
A colorimetric method for the determination of serum glutamic oxalacetic and glutamic pyruvic transaminases.
Stanley Reitman,Sam Frankel +1 more
Journal ArticleDOI
Flavonoids, a class of natural products of high pharmacological potency
TL;DR: The few existing reports on the careful pharmacodynamic, pharmacokinetic and clinical studies which have been made have been summarized to provide a basis for a full-scale investigation of the therapeutic potential of flavonoids.
Journal ArticleDOI
Anti-inflammatory steroids induce biosynthesis of a phospholipase A2 inhibitor which prevents prostaglandin generation.
R J Flower,G J Blackwell +1 more
TL;DR: It is shown that similar events occur in the guinea pig perfused lung before inhibition by steroids of phospholipase A2 activity (and thus TXA2 generation), and a steroid-induced factor is discovered which mimics the anti-phospholipases effects of these anti-inflammatory agents.
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