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Chieh Hsu
Researcher at University of Kent
Publications - 10
Citations - 4043
Chieh Hsu is an academic researcher from University of Kent. The author has contributed to research in topics: Vesicle & Endosome. The author has an hindex of 6, co-authored 9 publications receiving 3368 citations. Previous affiliations of Chieh Hsu include University of Basel & Max Planck Society.
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Journal ArticleDOI
Ceramide Triggers Budding of Exosome Vesicles into Multivesicular Endosomes
Katarina Trajkovic,Chieh Hsu,Salvatore Chiantia,Lawrence Rajendran,Dirk Wenzel,Felix T. Wieland,Petra Schwille,Britta Brügger,Mikael Simons +8 more
TL;DR: It is found that cargo is segregated into distinct subdomains on the endosomal membrane and that the transfer of exosome-associated domains into the lumen of theendosome did not depend on the function of the ESCRT (endosomal sorting complex required for transport) machinery, but required the sphingolipid ceramide.
Journal ArticleDOI
Regulation of exosome secretion by Rab35 and its GTPase-activating proteins TBC1D10A–C
Chieh Hsu,Yuichi Morohashi,Shin-ichiro Yoshimura,Natalia Manrique-Hoyos,SangYong Jung,Marcel A. Lauterbach,Mostafa Bakhti,Mads Grønborg,Wiebke Möbius,Jeong-Seop Rhee,Francis A. Barr,Mikael Simons +11 more
TL;DR: A screen in oligodendrocytes establishes a Rab family member and its GAPs as regulators of exosome secretion by controlling endocytic vesicle docking with the plasma membrane.
Journal ArticleDOI
Radio Imaging of the Very-High-Energy gamma-Ray Emission Region in the Central Engine of a Radio Galaxy
V. A. Acciari,E. Aliu,T. C. Arlen,Manuel A. Bautista,M. Beilicke,Wystan Benbow,S. M. Bradbury,J. H. Buckley,V. Bugaev,Yousaf M. Butt,Karen Byrum,A. Cannon,O. Celik,A. Cesarini,Y. C. Chow,L. Ciupik,P. Cogan,Wei Cui,R. Dickherber,S. J. Fegan,J. P. Finley,P. Fortin,Lucy Fortson,Amy Furniss,Daniel Gall,G. H. Gillanders,J. Grube,R. Guenette,Geza Gyuk,D. S. Hanna,Jamie Holder,D. Horan,C. M. Hui,Thomas Brian Humensky,A. Imran,P. Kaaret,N. Karlsson,David Kieda,John Kildea,A. Konopelko,Henric Krawczynski,Frank Krennrich,M. J. Lang,S. LeBohec,Gernot Maier,A. McCann,M. McCutcheon,J. Millis,P. Moriarty,R. A. Ong,A. N. Otte,D. Pandel,J. S. Perkins,D. Petry,Martin Pohl,John L. Quinn,K. Ragan,Luis C. Reyes,P. T. Reynolds,E. Roache,H. J. Rose,M. Schroedter,G. H. Sembroski,A. W. Smith,S. P. Swordy,M. Theiling,John Toner,A. Varlotta,S. Vincent,S. P. Wakely,J. E. Ward,T. C. Weekes,Amanda Weinstein,D. A. Williams,Stephanie Wissel,Matthew Wood,R. C. Walker,F. Davies,P. E. Hardee,W. Junor,C. Ly,Felix Aharonian,A. G. Akhperjanian,Gisela Anton,Almeida U. Barres De,A. R. Bazer-Bachi,Yvonne Becherini,B. Behera,K. Bernloehr,A. Bochow,C. Boisson,J. Bolmont,V. Borrel,J. Brucker,F. Brun,Pierre Brun,R. Buehler,T. Bulik,I. Buesching,Timothé Boutelier,P. M. Chadwick,A. Charbonnier,R. C. G. Chaves,A. Cheesebrough,L.-M. Chounet,A. C. Clapson,G. Coignet,M. Dalton,M. K. Daniel,I.D. Davids,B. Degrange,Christoph Deil,Hugh Dickinson,A. Djannati-Ataï,W. Domainko,L. O'c. Drury,Franky Dubois,Guillaume Dubus,J. Dyks,Michal Dyrda,K. Egberts,Dimitrios Emmanoulopoulos,P. Espigat,Christian Farnier,F. Feinstein,A. Fiasson,A. Foerster,G. Fontaine,M. Fuessling,Stefano Gabici,Y. A. Gallant,L. Gérard,D. Gerbig,B. Giebels,J. F. Glicenstein,B. Glueck,P. Goret,D. Goehring,D. Hauser,M. Hauser,S. Heinz,G. Heinzelmann,Gilles Henri,G. Hermann,Jim Hinton,A. Hoffmann,Werner Hofmann,M. Holleran,S. Hoppe,Dieter Horns,A. Jacholkowska,Jager O. C. de,C. Jahn,I. Jung,K. Katarzyński,U. F. Katz,Sarah Kaufmann,Eckhard Kendziorra,M. Kerschhaggl,D. Khangulyan,B. Khélifi,D. Keogh,W. Kluzniak,T. Kneiske,Nu. Komin,K. Kosack,G. Lamanna,J.-P. Lenain,Thomas Lohse,V. Marandon,J. M. Martin,Olivier Martineau-Huynh,Alexandre Marcowith,David Maurin,T. J. L. McComb,M. C. Medina,Rafał Moderski,Emmanuel Moulin,M. Naumann-Godo,Naurois M. De,D. Nedbal,D. Nekrassov,B. Nicholas,Jacek Niemiec,S. J. Nolan,Stefan Ohm,J-F. Olive,E. de Oña Wilhelmi,K. J. Orford,Michał Ostrowski,M. Panter,M. Paz Arribas,G. Pedaletti,G. Pelletier,P.-O. Petrucci,S. Pita,Michael Punch,M. Raue,S. M. Rayner,M. Renaud,Frank M. Rieger,J. Ripken,L. Rob,S. Rosier-Lees,Gavin Rowell,B. Rudak,Cameron B Rulten,J. Ruppel,V. Sahakian,Andrea Santangelo,Reinhard Schlickeiser,F. M. Schoeck,R. Schroeder,Ullrich Schwanke,S. Schwarzburg,S. Schwemmer,A. Shalchi,M. Sikora,J. L. Skilton,Helene Sol,D. Spangler,Lukasz Stawarz,R. Steenkamp,C. Stegmann,F. Stinzing,G. Superina,Anna Szostek,P. H. Tam,J.-P. Tavernet,Regis Terrier,O. Tibolla,O. Tibolla,M. Tluczykont,Eldik C. Van,G. Vasileiadis,Christo Venter,L. Venter,J. P. Vialle,Pascal Vincent,M. Vivier,H. J. Voelk,F. Volpe,Stefan Wagner,Martin Ward,Andrzej A. Zdziarski,A. Zech,H. Anderhub,L. A. Antonelli,P. Antoranz,Michael Backes,C. Baixeras,S. Balestra,Juan Abel Barrio,Denis Bastieri,J. Becerra Gonzlez,J. K. Becker,W. Bednarek,K. Berger,Elisa Bernardini,Adrian Biland,Ralph Bock,Giacomo Bonnoli,Pol Bordas,D. Borla Tridon,Valentí Bosch-Ramon,D. Bose,Ilana M. Braun,Thomas Bretz,I. Britvitch,M. Camara,E. Carmona,S. Commichau,Jose Luis Contreras,Juan Cortina,M. T. Costado,Stefano Covino,V. Curtef,Francesco Dazzi,Angelis A. De,Pozo E. de Cea Del,C. Delgado Mendez,Los Reyes R. De,Lotto B. De,Maria M. De,Sabata F. De,Aaron Dominguez,Daniela Dorner,Michele Doro,D. Elsaesser,Manel Errando,Daniel Ferenc,E. Fernndez,R. Firpo,M. V. Fonseca,Ll. Font,Nicola Galante,R. J. García López,M. Garczarczyk,M. Gaug,Florian Goebel,D. Hadasch,Masaaki Hayashida,A. Herrero,Dorothee Hildebrand,D. Hoehne-Moench,J. Hose,Chieh Hsu,T. Jogler,Daniel Kranich,Barbera A. La,A. Laille,E. Leonardo,Elina Lindfors,Saverio Lombardi,Francesco Longo,Morgan Lopez,E. Lorenz,Pratik Majumdar,G. Maneva,Nijil Mankuzhiyil,Karl Mannheim,L. Maraschi,Mosè Mariotti,M. I. Martínez,Daniel Mazin,Mario Meucci,Jose Miguel Miranda,R. Mirzoyan,H. Miyamoto,Javier Moldon,Mariano Moles,Abelardo Moralejo,Daniel Nieto,Kari Nilsson,Jelena Ninkovic,Igor Oya,Riccardo Paoletti,J. M. Paredes,M. Pasanen,D. Pascoli,Felicitas Pauss,R. G. Pegna,Miguel A. Pérez-Torres,Massimo Persic,L. Peruzzo,Francisco Prada,E. Prandini,N. Puchades,Ignasi Reichardt,Wolfgang Rhode,Marc Ribó,J. Rico,M. Rissi,A. Robert,S. Ruegamer,A. Saggion,T. Y. Saito,M. Salvati,Miguel A. Sánchez-Conde,Konstancja Satalecka,V. Scalzotto,V. Scapin,T. Schweizer,M. Shayduk,S. N. Shore,N. Sidro,Diego F. Torres,A. Sierpowska-Bartosik,A. Sillanpää,Julian Sitarek,Dorota Sobczyńska,Felix Spanier,Antonio Stamerra,L. S. Stark,L. O. Takalo,Fabrizio Tavecchio,Petar Temnikov,D. Tescaro,Masahiro Teshima,Nicola Turini,H. Vankov,Robert Wagner,Victor Zabalza,Fabio Zandanel,Roberta Zanin,J. Zapatero +385 more
TL;DR: Radio and VHE observations of the radio galaxy Messier 87 are revealed, revealing a period of extremely strong VHE gamma-ray flares accompanied by a strong increase of theRadio flux from its nucleus, implying that charged particles are accelerated to very high energies in the immediate vicinity of the black hole.
Journal ArticleDOI
Estrogen-Dependent Gene Transcription in Human Breast Cancer Cells Relies upon Proteasome-Dependent Monoubiquitination of Histone H2B
Tanja Prenzel,Yvonne Begus-Nahrmann,Frank Kramer,Magali Hennion,Chieh Hsu,Theresa Gorsler,Corinna Hintermair,Dirk Eick,Elisabeth Kremmer,Mikael Simons,Tim Beissbarth,Steven A. Johnsen +11 more
TL;DR: The transcriptome-wide effects of the proteasome inhibitor bortezomib on estrogen-regulated transcription in MCF7 human breast cancer cells were investigated and it was found that H2Bub1 levels decrease during tumor progression, supporting a tumor suppressor role for H2bub1 in breast cancer.
Journal ArticleDOI
Protein Dimerization Generates Bistability in Positive Feedback Loops
TL;DR: This work constructed transcriptional feedback loops in yeast by modulating two ultrasensitive reactions, homodimerization and the cooperative binding of the transcription factor to the promoter, and found that when acting together, a particularly robust bistability emerges.