S
Samer K. Elbabaa
Researcher at Arnold Palmer Hospital for Children
Publications - 73
Citations - 2699
Samer K. Elbabaa is an academic researcher from Arnold Palmer Hospital for Children. The author has contributed to research in topics: Medicine & Endoscopic third ventriculostomy. The author has an hindex of 17, co-authored 66 publications receiving 2055 citations. Previous affiliations of Samer K. Elbabaa include University of Arkansas for Medical Sciences & Orlando Regional Medical Center.
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Journal ArticleDOI
Subgroup-specific structural variation across 1,000 medulloblastoma genomes
Paul A. Northcott,Paul A. Northcott,David Shih,John Peacock,Livia Garzia,A. Sorana Morrissy,Thomas Zichner,Adrian M. Stütz,Andrey Korshunov,Jüri Reimand,Steven E. Schumacher,Rameen Beroukhim,Rameen Beroukhim,David W. Ellison,Christian R. Marshall,Anath C. Lionel,Stephen C. Mack,Adrian M. Dubuc,Yuan Yao,Vijay Ramaswamy,Betty Luu,Adi Rolider,Florence M.G. Cavalli,Xin Wang,Marc Remke,Xiaochong Wu,Readman Chiu,Andy Chu,Eric Chuah,Richard Corbett,Gemma Hoad,Shaun D. Jackman,Yisu Li,Allan Lo,Karen Mungall,Ka Ming Nip,Jenny Q. Qian,Anthony Raymond,Nina Thiessen,Richard Varhol,Inanc Birol,Richard A. Moore,Andrew J. Mungall,Robert A. Holt,Daisuke Kawauchi,Martine F. Roussel,Marcel Kool,David T.W. Jones,Hendrick Witt,Africa Fernandez-L,Anna Kenney,Robert J. Wechsler-Reya,Peter B. Dirks,Tzvi Aviv,Wiesława Grajkowska,Marta Perek-Polnik,Christine Haberler,Olivier Delattre,Stéphanie Reynaud,François Doz,Sarah S. Pernet-Fattet,Byung Kyu Cho,Seung-Ki Kim,Kyu-Chang Wang,Wolfram Scheurlen,Charles G. Eberhart,Michelle Fèvre-Montange,Anne Jouvet,Ian F. Pollack,Xing Fan,Karin M. Muraszko,G. Yancey Gillespie,Concezio Di Rocco,Luca Massimi,Erna M.C. Michiels,Nanne K. Kloosterhof,Pim J. French,Johan M. Kros,James M. Olson,Richard G. Ellenbogen,Karel Zitterbart,Leos Kren,Reid C. Thompson,Michael K. Cooper,Boleslaw Lach,Boleslaw Lach,Roger E. McLendon,Darell D. Bigner,Adam M. Fontebasso,Steffen Albrecht,Steffen Albrecht,Nada Jabado,Janet C. Lindsey,Simon Bailey,Nalin Gupta,William A. Weiss,László Bognár,Almos Klekner,Timothy E. Van Meter,Toshihiro Kumabe,Teiji Tominaga,Samer K. Elbabaa,Jeffrey R. Leonard,Joshua B. Rubin,Linda M. Liau,Erwin G. Van Meir,Maryam Fouladi,Hideo Nakamura,Giuseppe Cinalli,Miklós Garami,Peter Hauser,Ali G. Saad,Achille Iolascon,Shin Jung,Carlos Gilberto Carlotti,Rajeev Vibhakar,Young Shin Ra,Shenandoah Robinson,Massimo Zollo,Claudia C. Faria,Jennifer A. Chan,Michael J. Levy,Poul H. Sorensen,Matthew Meyerson,Scott L. Pomeroy,Yoon Jae Cho,Gary D. Bader,Uri Tabori,Cynthia Hawkins,Eric Bouffet,Stephen W. Scherer,James T. Rutka,David Malkin,Steven C. Clifford,Steven J.M. Jones,Jan O. Korbel,Stefan M. Pfister,Stefan M. Pfister,Marco A. Marra,Michael D. Taylor +139 more
TL;DR: Somatic copy number aberrations (SCNAs) in 1,087 unique medulloblastomas are reported, including recurrent events targeting TGF-β signalling in Group 3, and NF-κB signalling in Groups 4, which suggest future avenues for rational, targeted therapy.
Journal ArticleDOI
Intertumoral Heterogeneity within Medulloblastoma Subgroups
Florence M.G. Cavalli,Marc Remke,Marc Remke,Marc Remke,Ladislav Rampášek,John Peacock,David Shih,Betty Luu,Livia Garzia,Jonathon Torchia,Carolina Nor,A. Sorana Morrissy,Sameer Agnihotri,Yuan Yao Thompson,Claudia M. Kuzan-Fischer,Hamza Farooq,Keren Isaev,Keren Isaev,Craig Daniels,Byung Kyu Cho,Seung-Ki Kim,Kyu-Chang Wang,Ji Yeoun Lee,Wiesława Grajkowska,Marta Perek-Polnik,Alexandre Vasiljevic,Cécile Faure-Conter,Anne Jouvet,Caterina Giannini,Amulya A. Nageswara Rao,Kay Ka Wai Li,Ho Keung Ng,Charles G. Eberhart,Ian F. Pollack,Ronald L. Hamilton,G. Yancey Gillespie,James M. Olson,James M. Olson,Sarah Leary,William A. Weiss,Boleslaw Lach,Boleslaw Lach,Lola B. Chambless,Reid C. Thompson,Michael K. Cooper,Rajeev Vibhakar,Peter Hauser,Marie Lise C. van Veelen,Johan M. Kros,Pim J. French,Young Shin Ra,Toshihiro Kumabe,Enrique López-Aguilar,Karel Zitterbart,Jaroslav Sterba,Gaetano Finocchiaro,Maura Massimino,Erwin G. Van Meir,Satoru Osuka,Tomoko Shofuda,Almos Klekner,Massimo Zollo,Jeffrey R. Leonard,Joshua B. Rubin,Nada Jabado,Steffen Albrecht,Steffen Albrecht,Jaume Mora,Timothy E. Van Meter,Shin Jung,Andrew S. Moore,Andrew R. Hallahan,Jennifer A. Chan,Daniela Pretti da Cunha Tirapelli,Carlos Gilberto Carlotti,Maryam Fouladi,José Pimentel,Claudia C. Faria,Ali G. Saad,Luca Massimi,Linda M. Liau,Helen Wheeler,Hideo Nakamura,Samer K. Elbabaa,Mario Perezpeña-Diazconti,Fernando Chico Ponce de León,Shenandoah Robinson,Michal Zapotocky,Alvaro Lassaletta,Annie Huang,Cynthia Hawkins,Uri Tabori,Eric Bouffet,Ute Bartels,Peter B. Dirks,James T. Rutka,Gary D. Bader,Jüri Reimand,Jüri Reimand,Anna Goldenberg,Vijay Ramaswamy,Michael D. Taylor +101 more
TL;DR: Similarity network fusion (SNF) applied to genome-wide DNA methylation and gene expression data across 763 primary samples identifies very homogeneous clusters of patients, supporting the presence of medulloblastoma subtypes.
Journal ArticleDOI
TERT promoter mutations are highly recurrent in SHH subgroup medulloblastoma
Marc Remke,Vijaj Ramaswamy,John Peacock,David Shih,Christian Koelsche,Christian Koelsche,Paul A. Northcott,Nadia Hill,Florence M.G. Cavalli,Marcel Kool,Xin Wang,Stephen C. Mack,Mark Barszczyk,Sorana Morrissy,Xiaochong Wu,Sameer Agnihotri,Betty Luu,David T.W. Jones,Livia Garzia,Adrian M. Dubuc,Nataliya Zhukova,Robert Vanner,Johan M. Kros,Pim J. French,Erwin G. Van Meir,Rajeev Vibhakar,Karel Zitterbart,Jennifer A. Chan,László Bognár,Almos Klekner,Boleslaw Lach,Shin Jung,Ali G. Saad,Linda M. Liau,Steffen Albrecht,Massimo Zollo,Michael K. Cooper,Reid C. Thompson,Olivier Delattre,Franck Bourdeaut,François Doz,Miklós Garami,Peter Hauser,Carlos Gilberto Carlotti,Timothy E. Van Meter,Luca Massimi,Daniel W. Fults,Scott L. Pomeroy,Toshiro Kumabe,Young-Shin Ra,Jeffrey R. Leonard,Samer K. Elbabaa,Jaume Mora,Joshua B. Rubin,Yoon Jae Cho,Roger E. McLendon,Darell D. Bigner,Charles G. Eberhart,Maryam Fouladi,Robert J. Wechsler-Reya,Claudia C. Faria,Claudia C. Faria,Sidney Croul,Annie Huang,Eric Bouffet,Cynthia Hawkins,Peter B. Dirks,William A. Weiss,Ulrich Schüller,Ian F. Pollack,Stefan Rutkowski,David Meyronet,Anne Jouvet,Michelle Fèvre-Montange,Nada Jabado,Marta Perek-Polnik,Wiesława Grajkowska,Seungki-Ki Kim,James T. Rutka,David Malkin,Uri Tabori,Stefan M. Pfister,Stefan M. Pfister,Andrey Korshunov,Andrey Korshunov,Andreas von Deimling,Andreas von Deimling,Michael D. Taylor +87 more
TL;DR: TERT mutations define a subset of SHH medulloblastoma with distinct demographics, cytogenetics, and outcomes, and are very highly enriched in adult SHH and WNT tumors.
Journal ArticleDOI
Therapeutic Impact of Cytoreductive Surgery and Irradiation of Posterior Fossa Ependymoma in the Molecular Era: A Retrospective Multicohort Analysis
Vijay Ramaswamy,Thomas Hielscher,Stephen C. Mack,Stephen C. Mack,Alvaro Lassaletta,Tong Lin,Kristian W. Pajtler,David T.W. Jones,Betty Luu,Florence M.G. Cavalli,Kenneth Aldape,Marc Remke,Martin Mynarek,Stefan Rutkowski,Sridharan Gururangan,Roger E. McLendon,Eric S. Lipp,Christopher Dunham,Juliette Hukin,David D. Eisenstat,Dorcas Fulton,Frank van Landeghem,Mariarita Santi,Marie Lise C. van Veelen,Erwin G. Van Meir,Satoru Osuka,Xing Fan,Karin M. Muraszko,Daniela Pretti da Cunha Tirapelli,Sueli Mieko Oba-Shinjo,Suely Kazue Nagahashi Marie,Carlos Gilberto Carlotti,Ji Yeoun Lee,Amulya A. Nageswara Rao,Caterina Giannini,Claudia C. Faria,Sofia Nunes,Jaume Mora,Ronald L. Hamilton,Peter Hauser,Nada Jabado,Kevin Petrecca,Shin Jung,Luca Massimi,Massimo Zollo,Giuseppe Cinalli,László Bognár,Almos Klekner,Tibor Hortobágyi,Sarah Leary,Sarah Leary,Sarah Leary,Ralph P. Ermoian,Ralph P. Ermoian,Ralph P. Ermoian,James M. Olson,James M. Olson,James M. Olson,Jeffrey R. Leonard,Corrine Gardner,Wiesława Grajkowska,Lola B. Chambless,Jason E. Cain,Charles G. Eberhart,Sama Ahsan,Maura Massimino,Felice Giangaspero,Francesca R. Buttarelli,Roger J. Packer,Lyndsey Emery,William H. Yong,Horacio Soto,Linda M. Liau,Richard Everson,Andrew J. Grossbach,Tarek Shalaby,Michael A. Grotzer,Matthias A. Karajannis,David Zagzag,Helen Wheeler,Katja von Hoff,Marta M. Alonso,Teresa Tuñón,Ulrich Schüller,Karel Zitterbart,Jaroslav Sterba,Jennifer A. Chan,Miguel A. Guzman,Samer K. Elbabaa,Howard Colman,Girish Dhall,Paul G. Fisher,Maryam Fouladi,Amar Gajjar,Stewart Goldman,Eugene Hwang,Marcel Kool,Harshad Ladha,Elizabeth Vera-Bolanos,Khalida Wani,Frank S. Lieberman,Tom Mikkelsen,Antonio Omuro,Ian F. Pollack,Michael D. Prados,H. Ian Robins,Riccardo Soffietti,Jing Wu,Phillipe Metellus,Uri Tabori,Ute Bartels,Eric Bouffet,Cynthia Hawkins,James T. Rutka,Peter B. Dirks,Stefan M. Pfister,Stefan M. Pfister,Thomas E. Merchant,Mark R. Gilbert,Mark R. Gilbert,Terri S. Armstrong,Andrey Korshunov,David W. Ellison,Michael D. Taylor +123 more
TL;DR: The most impactful biomarker for posterior fossa ependymoma is molecular subgroup affiliation, independent of other demographic or treatment variables, with the survival rates being particularly poor for subtotally resected EPN_PFA, even with adjuvant radiation therapy.
Journal ArticleDOI
The Dandy-Walker variant: a case series of 24 pediatric patients and evaluation of associated anomalies, incidence of hydrocephalus, and developmental outcomes.
Deanna Sasaki-Adams,Samer K. Elbabaa,Samer K. Elbabaa,Valerie Jewells,Lori Carter,Jeffrey W. Campbell,Ann M. Ritter +6 more
TL;DR: Developmental outcome was solely affected by neurological deficits and that ventricular enlargement predicted the need for shunt placement, and the DWV was associated with both extra- and intracranial anomalies.