Y
Yisu Li
Researcher at University of British Columbia
Publications - 9
Citations - 1230
Yisu Li is an academic researcher from University of British Columbia. The author has contributed to research in topics: Medicine & Cancer. The author has an hindex of 6, co-authored 6 publications receiving 1042 citations. Previous affiliations of Yisu Li include BC Cancer Agency.
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Journal ArticleDOI
Subgroup-specific structural variation across 1,000 medulloblastoma genomes
Paul A. Northcott,Paul A. Northcott,David Shih,John Peacock,Livia Garzia,A. Sorana Morrissy,Thomas Zichner,Adrian M. Stütz,Andrey Korshunov,Jüri Reimand,Steven E. Schumacher,Rameen Beroukhim,Rameen Beroukhim,David W. Ellison,Christian R. Marshall,Anath C. Lionel,Stephen C. Mack,Adrian M. Dubuc,Yuan Yao,Vijay Ramaswamy,Betty Luu,Adi Rolider,Florence M.G. Cavalli,Xin Wang,Marc Remke,Xiaochong Wu,Readman Chiu,Andy Chu,Eric Chuah,Richard Corbett,Gemma Hoad,Shaun D. Jackman,Yisu Li,Allan Lo,Karen Mungall,Ka Ming Nip,Jenny Q. Qian,Anthony Raymond,Nina Thiessen,Richard Varhol,Inanc Birol,Richard A. Moore,Andrew J. Mungall,Robert A. Holt,Daisuke Kawauchi,Martine F. Roussel,Marcel Kool,David T.W. Jones,Hendrick Witt,Africa Fernandez-L,Anna Kenney,Robert J. Wechsler-Reya,Peter B. Dirks,Tzvi Aviv,Wiesława Grajkowska,Marta Perek-Polnik,Christine Haberler,Olivier Delattre,Stéphanie Reynaud,François Doz,Sarah S. Pernet-Fattet,Byung Kyu Cho,Seung-Ki Kim,Kyu-Chang Wang,Wolfram Scheurlen,Charles G. Eberhart,Michelle Fèvre-Montange,Anne Jouvet,Ian F. Pollack,Xing Fan,Karin M. Muraszko,G. Yancey Gillespie,Concezio Di Rocco,Luca Massimi,Erna M.C. Michiels,Nanne K. Kloosterhof,Pim J. French,Johan M. Kros,James M. Olson,Richard G. Ellenbogen,Karel Zitterbart,Leos Kren,Reid C. Thompson,Michael K. Cooper,Boleslaw Lach,Boleslaw Lach,Roger E. McLendon,Darell D. Bigner,Adam M. Fontebasso,Steffen Albrecht,Steffen Albrecht,Nada Jabado,Janet C. Lindsey,Simon Bailey,Nalin Gupta,William A. Weiss,László Bognár,Almos Klekner,Timothy E. Van Meter,Toshihiro Kumabe,Teiji Tominaga,Samer K. Elbabaa,Jeffrey R. Leonard,Joshua B. Rubin,Linda M. Liau,Erwin G. Van Meir,Maryam Fouladi,Hideo Nakamura,Giuseppe Cinalli,Miklós Garami,Peter Hauser,Ali G. Saad,Achille Iolascon,Shin Jung,Carlos Gilberto Carlotti,Rajeev Vibhakar,Young Shin Ra,Shenandoah Robinson,Massimo Zollo,Claudia C. Faria,Jennifer A. Chan,Michael J. Levy,Poul H. Sorensen,Matthew Meyerson,Scott L. Pomeroy,Yoon Jae Cho,Gary D. Bader,Uri Tabori,Cynthia Hawkins,Eric Bouffet,Stephen W. Scherer,James T. Rutka,David Malkin,Steven C. Clifford,Steven J.M. Jones,Jan O. Korbel,Stefan M. Pfister,Stefan M. Pfister,Marco A. Marra,Michael D. Taylor +139 more
TL;DR: Somatic copy number aberrations (SCNAs) in 1,087 unique medulloblastomas are reported, including recurrent events targeting TGF-β signalling in Group 3, and NF-κB signalling in Groups 4, which suggest future avenues for rational, targeted therapy.
Journal ArticleDOI
Divergent clonal selection dominates medulloblastoma at recurrence
A. Sorana Morrissy,Livia Garzia,David Shih,Scott Zuyderduyn,Xi Huang,Patryk Skowron,Marc Remke,Florence M.G. Cavalli,Vijay Ramaswamy,Patricia Lindsay,Salomeh Jelveh,Laura K. Donovan,Xin Wang,Betty Luu,Kory Zayne,Yisu Li,Chelsea Mayoh,Nina Thiessen,Eloi Mercier,Karen Mungall,Yusanne Ma,Kane Tse,Thomas Zeng,Karey Shumansky,Andrew Roth,Sohrab P. Shah,Hamza Farooq,Noriyuki Kijima,Borja L. Holgado,John J.Y. Lee,Stuart Matan-Lithwick,Jessica Liu,Stephen C. Mack,Stephen C. Mack,Alex Manno,K. A. Michealraj,Carolina Nor,John Peacock,Lei Qin,Jüri Reimand,Adi Rolider,Yuan Yao Thompson,Xiaochong Wu,Trevor J. Pugh,Adrian Ally,Mikhail Bilenky,Yaron S.N. Butterfield,Rebecca Carlsen,Young Cheng,Eric Chuah,Richard Corbett,Noreen Dhalla,An He,Darlene Lee,Haiyan I. Li,William Long,Michael Mayo,Patrick Plettner,Jenny Q. Qian,Jacqueline E. Schein,Angela Tam,Tina Wong,Inanc Birol,Inanc Birol,Yongjun Zhao,Claudia C. Faria,José Pimentel,Sofia Nunes,Tarek Shalaby,Michael A. Grotzer,Ian F. Pollack,Ronald L. Hamilton,Xiao-Nan Li,Anne Bendel,Daniel W. Fults,Andrew W. Walter,Toshihiro Kumabe,Teiji Tominaga,V. Peter Collins,Yoon Jae Cho,Caitlin Hoffman,David Lyden,Jeffrey H. Wisoff,James Garvin,Duncan Stearns,Luca Massimi,Ulrich Schüller,Jaroslav Sterba,Karel Zitterbart,Stéphanie Puget,Olivier Ayrault,Sandra E. Dunn,Daniela Pretti da Cunha Tirapelli,Carlos Gilberto Carlotti,Helen Wheeler,Andrew R. Hallahan,Wendy J. Ingram,Tobey J. MacDonald,Jeffrey J. Olson,Erwin G. Van Meir,Ji Yeoun Lee,Kyu-Chang Wang,Seung-Ki Kim,Byung Kyu Cho,Torsten Pietsch,Gudrun Fleischhack,Stephan Tippelt,Young Shin Ra,Simon Bailey,Janet C. Lindsey,Steven C. Clifford,Charles G. Eberhart,Michael K. Cooper,Roger J. Packer,Maura Massimino,Maria Luisa Garrè,Ute Bartels,Uri Tabori,Cynthia Hawkins,Peter B. Dirks,Eric Bouffet,James T. Rutka,Robert J. Wechsler-Reya,William A. Weiss,Lara S. Collier,Adam J. Dupuy,Andrey Korshunov,David T.W. Jones,Marcel Kool,Paul A. Northcott,Stefan M. Pfister,Stefan M. Pfister,David A. Largaespada,Andrew J. Mungall,Richard A. Moore,Nada Jabado,Gary D. Bader,Steven J.M. Jones,Steven J.M. Jones,David Malkin,Marco A. Marra,Michael D. Taylor +141 more
TL;DR: Targeted therapy is unlikely to be effective in the absence of the target, therefore the results offer a simple, proximal, and remediable explanation for the failure of prior clinical trials of targeted therapy.
Journal ArticleDOI
Medulloblastoma-associated DDX3 variant selectively alters the translational response to stress
Sekyung Oh,Ryan A. Flynn,Stephen N. Floor,James Purzner,James Purzner,Lance Martin,Brian T. Do,Simone Schubert,Dedeepya Vaka,Sorana Morrissy,Yisu Li,Marcel Kool,Volker Hovestadt,David T.W. Jones,Paul A. Northcott,Thomas Risch,Hans-Jörg Warnatz,Marie-Laure Yaspo,Christopher M. Adams,Ryan D. Leib,Marcus R. Breese,Marco A. Marra,David Malkin,Peter Lichter,Jennifer A. Doudna,Jennifer A. Doudna,Stefan M. Pfister,Michael D. Taylor,Michael D. Taylor,Howard Y. Chang,Yoon Jae Cho,Yoon Jae Cho +31 more
TL;DR: It is shown that despite the global repression of translation induced by arsenite, translation is preserved on select genes involved in chromatin organization in DDX3R534H-expressing cells, while cancer-relatedDDX3 variants adapt this response to selectively preserve translation.
Journal ArticleDOI
JAGuaR: junction alignments to genome for RNA-seq reads.
Yaron S.N. Butterfield,Maayan Kreitzman,Nina Thiessen,Richard Corbett,Yisu Li,Johnson Pang,Yussanne Ma,Steven J.M. Jones,Inanc Birol +8 more
TL;DR: This work demonstrates how JAGuaR generates fast and accurate transcriptome alignments, which allows for both sensitive and specific SNV calling.
Journal ArticleDOI
Pyruvate Kinase Inhibits Proliferation during Postnatal Cerebellar Neurogenesis and Suppresses Medulloblastoma Formation.
Katherine Tech,Andrey P. Tikunov,Hamza Farooq,A. Sorana Morrissy,Jessica Meidinger,Taylor Fish,Sarah C. Green,Hedi Liu,Yisu Li,Andrew J. Mungall,Richard A. Moore,Yussanne Ma,Steven J.M. Jones,Marco A. Marra,Matthew G. Vander Heiden,Matthew G. Vander Heiden,Michael D. Taylor,Jeffrey M. Macdonald,Timothy R. Gershon +18 more
TL;DR: In this paper, pyruvate kinase-M (Pkm), an enzyme that acts in the terminal steps of glycolysis, was shown to have opposite effects on proliferation and tumorigenesis.