D
David Enot
Researcher at Institut Gustave Roussy
Publications - 80
Citations - 11106
David Enot is an academic researcher from Institut Gustave Roussy. The author has contributed to research in topics: Immune system & Immunosurveillance. The author has an hindex of 41, co-authored 80 publications receiving 8718 citations. Previous affiliations of David Enot include University of Paris-Sud & Aberystwyth University.
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Journal ArticleDOI
Anticancer immunotherapy by CTLA-4 blockade relies on the gut microbiota
Marie Vétizou,Marie Vétizou,Marie Vétizou,Jonathan M. Pitt,Jonathan M. Pitt,Jonathan M. Pitt,Romain Daillère,Romain Daillère,Romain Daillère,Patricia Lepage,Nadine Waldschmitt,Caroline Flament,Caroline Flament,Sylvie Rusakiewicz,Sylvie Rusakiewicz,Bertrand Routy,Maria Paula Roberti,Maria Paula Roberti,Connie P.M. Duong,Connie P.M. Duong,Vichnou Poirier-Colame,Vichnou Poirier-Colame,Antoine Roux,Antoine Roux,Antoine Roux,Sonia Becharef,Sonia Becharef,Silvia C. Formenti,Encouse B. Golden,Sascha Cording,Gérard Eberl,Andreas Schlitzer,Florent Ginhoux,Sridhar Mani,Takahiro Yamazaki,Takahiro Yamazaki,Nicolas Jacquelot,Nicolas Jacquelot,Nicolas Jacquelot,David Enot,David Enot,Marion Bérard,Jérôme Nigou,Jérôme Nigou,Paule Opolon,Alexander M.M. Eggermont,Alexander M.M. Eggermont,Paul Louis Woerther,Elisabeth Chachaty,Nathalie Chaput,Nathalie Chaput,Caroline Robert,Caroline Robert,Christina Mateus,Guido Kroemer,Didier Raoult,Ivo G. Boneca,Ivo G. Boneca,Franck Carbonnel,Mathias Chamaillard,Laurence Zitvogel +60 more
TL;DR: A key role is revealed for Bacteroidales in the immunostimulatory effects of CTLA-4 blockade, which is found to depend on distinct Bacteroides species in mice and patients.
Journal ArticleDOI
The intestinal microbiota modulates the anticancer immune effects of cyclophosphamide
Sophie Viaud,Sophie Viaud,Fabiana Saccheri,Grégoire Mignot,Takahiro Yamazaki,Romain Daillère,Romain Daillère,Dalil Hannani,David Enot,David Enot,Christina Pfirschke,Camilla Engblom,Mikael J. Pittet,Andreas Schlitzer,Florent Ginhoux,Lionel Apetoh,Elisabeth Chachaty,Paul Louis Woerther,Gérard Eberl,Marion Bérard,Chantal Ecobichon,Chantal Ecobichon,Dominique Clermont,Chantal Bizet,Valérie Gaboriau-Routhiau,Valérie Gaboriau-Routhiau,Nadine Cerf-Bensussan,Nadine Cerf-Bensussan,Paule Opolon,Nadia Yessaad,Eric Vivier,Bernhard Ryffel,Charles O. Elson,Joël Doré,Joël Doré,Guido Kroemer,Patricia Lepage,Patricia Lepage,Ivo G. Boneca,Ivo G. Boneca,François Ghiringhelli,François Ghiringhelli,Laurence Zitvogel,Laurence Zitvogel,Laurence Zitvogel +44 more
TL;DR: It is demonstrated that cyclophosphamide alters the composition of microbiota in the small intestine and induces the translocation of selected species of Gram-positive bacteria into secondary lymphoid organs, which suggests that the gut microbiota help shape the anticancer immune response.
Journal ArticleDOI
Cancer cell–autonomous contribution of type I interferon signaling to the efficacy of chemotherapy
Antonella Sistigu,Takahiro Yamazaki,Erika Vacchelli,Kariman Chaba,David Enot,Julien Adam,Ilio Vitale,Aicha Goubar,Elisa E. Baracco,Catarina Remédios,Laetitia Fend,Dalil Hannani,Laetitia Aymeric,Yuting Ma,Mireia Niso-Santano,Oliver Kepp,Joachim L. Schultze,Thomas Tüting,Filippo Belardelli,Laura Bracci,Valentina La Sorsa,Giovanna Ziccheddu,Paola Sestili,Francesca Urbani,Mauro Delorenzi,Magali Lacroix-Triki,Virginie Quidville,Rosa Conforti,Jean Philippe Spano,Lajos Pusztai,Vichnou Poirier-Colame,Suzette Delaloge,Frédérique Penault-Llorca,Sylvain Ladoire,Laurent Arnould,Joanna Cyrta,Marie Charlotte Dessoliers,Alexander M.M. Eggermont,Marco Bianchi,Mikael J. Pittet,Camilla Engblom,Christina Pfirschke,Xavier Préville,Gilles Uzé,Robert D. Schreiber,Melvyn T. Chow,Mark J. Smyth,Enrico Proietti,Fabrice Andre,Guido Kroemer,Laurence Zitvogel +50 more
TL;DR: The data suggest that anthracycline-mediated immune responses mimic those induced by viral pathogens, and it is surmised that such 'viral mimicry' constitutes a hallmark of successful chemotherapy.
Journal ArticleDOI
Enterococcus hirae and Barnesiella intestinihominis Facilitate Cyclophosphamide-Induced Therapeutic Immunomodulatory Effects
Romain Daillère,Romain Daillère,Romain Daillère,Marie Vétizou,Marie Vétizou,Marie Vétizou,Nadine Waldschmitt,Takahiro Yamazaki,Takahiro Yamazaki,Christophe Isnard,Vichnou Poirier-Colame,Vichnou Poirier-Colame,Vichnou Poirier-Colame,Connie P.M. Duong,Connie P.M. Duong,Caroline Flament,Caroline Flament,Patricia Lepage,Maria Paula Roberti,Maria Paula Roberti,Bertrand Routy,Bertrand Routy,Bertrand Routy,Nicolas Jacquelot,Nicolas Jacquelot,Nicolas Jacquelot,Lionel Apetoh,Lionel Apetoh,Sonia Becharef,Sonia Becharef,Sylvie Rusakiewicz,Sylvie Rusakiewicz,Philippe Langella,Harry Sokol,Harry Sokol,Guido Kroemer,David Enot,Antoine Roux,Alexander M. M. Eggermont,Alexander M. M. Eggermont,Eric Tartour,Ludger Johannes,Ludger Johannes,Ludger Johannes,Paul Louis Woerther,Elisabeth Chachaty,Jean-Charles Soria,Jean-Charles Soria,Encouse B. Golden,Silvia C. Formenti,Magdalena Plebanski,Mutsa Tatenda Madondo,Philip Rosenstiel,Didier Raoult,Vincent Cattoir,Ivo G. Boneca,Mathias Chamaillard,Laurence Zitvogel +57 more
TL;DR: Enterococcus hirae and B. intestinihominis represent valuable "oncomicrobiotics" ameliorating the efficacy of the most common alkylating immunomodulatory compound CTX, and selectively predicted longer progression-free survival in advanced lung and ovarian cancer patients treated with chemo-immunotherapy.
Journal ArticleDOI
Regulation of Autophagy by Cytosolic Acetyl-Coenzyme A
Guillermo Mariño,Federico Pietrocola,Tobias Eisenberg,Yongli Kong,Shoaib Ahmad Malik,Aleksandra Andryushkova,Sabrina Schroeder,Tobias Pendl,Alexandra Harger,Mireia Niso-Santano,Naoufal Zamzami,Marie Scoazec,Silvère Durand,David Enot,Álvaro F. Fernández,Isabelle Martins,Oliver Kepp,Laura Senovilla,Chantal Bauvy,Chantal Bauvy,Eugenia Morselli,Erika Vacchelli,Martin V. Bennetzen,Christoph Magnes,Frank Sinner,Thomas R. Pieber,Carlos López-Otín,Maria Chiara Maiuri,Patrice Codogno,Patrice Codogno,Jens S. Andersen,Joseph A. Hill,Frank Madeo,Guido Kroemer +33 more
TL;DR: It is shown that nutrient starvation causes rapid depletion of AcCoA, and multiple distinct manipulations designed to increase or reduce cytosolic Ac CoA led to the suppression or induction of autophagy, respectively, both in cultured human cells and in mice, delineating Ac coenzyme A-centered pharmacological strategies that allow for the therapeutic manipulation ofautophagy.