Diederick E. Grobbee

TL;DR: Based on the Prospect-EPIC population, this manuscript intends to conduct prospective total cohort, nested case–control or case–cohort studies, in order to investigate relations between consumption of certain food groups or nutrients and chronic diseases, including hormone dependant cancers.

TL;DR: This study investigated the optimal analysing strategy for bleeding data by using the association of residual clotting factor level and number of joint bleeds in moderate and mild patients treated on demand as example, and found Multivariate regression analysis using negative binomial distribution provided the optimum data analytical strategy.

TL;DR: The T axis is a strong and independent risk indicator of fatal and non-fatal cardiac events in the elderly, and the risk associated with an abnormal T axis was higher than those for any other cardiovascular risk factor.

TL;DR: There was no consistent association of urinary sodium, potassium, or sodium/potassium ratio with CVD and all-cause mortality over the range of intakes observed in this population, and the effect of sodium and potassium intake on CVD morbidity and mortality in Western societies remains to be established.

TL;DR: High‐dose prophylaxis significantly increases treatment costs and reduces joint bleeds over a period of 3 years, but only slightly reduces arthropathy after 17’years of follow‐up, suggesting that, compared with intermediate‐doseProphylactic regimens, high‐dose Prophylactive regimens significantly increases Treatment costs and joint bleeding over aperiod of 3 years, butonly slightly reducesArthropathy.