D
Diederick E. Grobbee
Researcher at Utrecht University
Publications - 1108
Citations - 136069
Diederick E. Grobbee is an academic researcher from Utrecht University. The author has contributed to research in topics: Population & Risk factor. The author has an hindex of 155, co-authored 1051 publications receiving 122748 citations. Previous affiliations of Diederick E. Grobbee include National Heart Foundation of Australia & Radboud University Nijmegen Medical Centre.
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Journal ArticleDOI
Paraoxonase Variants Relate to 10-Year Risk in Coronary Artery Disease : Impact of a High-Density Lipoprotein–Bound Antioxidant in Secondary Prevention
Jakub J. Regieli,J. Wouter Jukema,Pieter A. Doevendans,Aeilko H. Zwinderman,John J.P. Kastelein,Diederick E. Grobbee,Yolanda van der Graaf +6 more
TL;DR: Functional data on PON-1 activity is confirmed, emphasize the relevance of this pathway in vascular disease, and enforce its putative role as a target to modify and estimate cardiovascular risk.
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Quantifying the added value of BNP in suspected heart failure in general practice: an individual patient data meta-analysis
Johannes C. Kelder,Martin R. Cowie,Theresa McDonagh,Suzanna M C Hardman,Diederick E. Grobbee,Bernard Cost,Arno W. Hoes +6 more
TL;DR: Using BNP alone with the currently recommended cut-off levels is not sufficient to make a reliable diagnosis of heart failure, but the ‘clinical plus BNP’ diagnostic model performed well in an independent cohort with comparable inclusion criteria.
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Interrupter Resistance and Wheezing Phenotypes at 4 Years of Age
J. E. Brussee,Henriette A. Smit,Laurens P. Koopman,Alet H. Wijga,Marjan Kerkhof,Karen Corver,Ada P. H. Vos,Jorrit Gerritsen,Diederick E. Grobbee,Bert Brunekreef,Peter J. F. M. Merkus,Johan C. de Jongste +11 more
TL;DR: Both in children with atopic and nonatopic mothers, children with persistent wheeze had significantly higher interrupter resistance values than children with never and early wheezing phenotypes.
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Enhanced blood pressure response to mild sodium reduction in subjects with the 235T variant of the angiotensinogen gene
Steven C. Hunt,Johanna M. Geleijnse,Lily Wu,Jacqueline C.M. Witteman,Roger R. Williams,Diederick E. Grobbee,Diederick E. Grobbee +6 more
TL;DR: It is concluded that the 235T allele of the angiotensinogen gene is associated with greater blood pressure decreases than the 235M allele after a sodium reduction intervention.
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Effects of a fixed combination of perindopril and indapamide in patients with type 2 diabetes and chronic kidney disease
Hiddo J.L. Heerspink,Hiddo J.L. Heerspink,Toshiharu Ninomiya,Vlado Perkovic,Mark Woodward,Sophia Zoungas,Sophia Zoungas,Alan Cass,Mark E. Cooper,Diederick E. Grobbee,Giuseppe Mancia,C. E. Mogensen,Bruce Neal,John Chalmers +13 more
TL;DR: The treatment benefits of a routine administration of a fixed combination of perindopril-indapamide to patients with type 2 diabetes on cardiovascular and renal outcomes, and death, are consistent across all stages of CKD at baseline.