D
Diederick E. Grobbee
Researcher at Utrecht University
Publications - 1108
Citations - 136069
Diederick E. Grobbee is an academic researcher from Utrecht University. The author has contributed to research in topics: Population & Risk factor. The author has an hindex of 155, co-authored 1051 publications receiving 122748 citations. Previous affiliations of Diederick E. Grobbee include National Heart Foundation of Australia & Radboud University Nijmegen Medical Centre.
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Journal ArticleDOI
The effects of postponing prophylactic treatment on long-term outcome in patients with severe hemophilia.
Krista Fischer,Johanna G. van der Bom,Eveline P. Mauser-Bunschoten,Goris Roosendaal,Robert Prejs,Piet de Kleijn,Diederick E. Grobbee,Marijke van den Berg +7 more
TL;DR: The effect of postponing prophylaxis on long-term arthropathy was studied in a cohort of 76 patients with severe hemophilia born between 1965 and 1985, finding that most patients have their first joint bleed after the age of 2 years.
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Plasma Total Homocysteine, B Vitamins, and Risk of Coronary Atherosclerosis
Petra Verhoef,Frans J. Kok,Dick A.C.M. Kruyssen,Evert G. Schouten,Jacqueline C.M. Witteman,Diederick E. Grobbee,Per Magne Ueland,Helga Refsum +7 more
TL;DR: The data show a positive association between plasma tHcy and risk of severe coronary atherosclerosis, of similar strength for fasting and postload tH Cy levels, and suggest that the association exists over a wide range of tHCy levels, without a clear cutoff point below which there is no increased risk.
Journal ArticleDOI
Adjuvant Aspirin Therapy Reduces Symptoms of Schizophrenia Spectrum Disorders : Results From a Randomized, Double-Blind, Placebo-Controlled Trial
Wijnand Laan,Diederick E. Grobbee,Jean-Paul Selten,Cobi Jacoba Johanna Heijnen,René S. Kahn,Huibert Burger +5 more
TL;DR: Aspirin given as adjuvant therapy to regular antipsychotic treatment reduces the symptoms of schizophrenia spectrum disorders, and is more pronounced in those with the more altered immune function.
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Serum Total IGF-I, Free IGF-I, and IGFBP-1 Levels in an Elderly Population Relation to Cardiovascular Risk Factors and Disease
Joseph A M J L Janssen,Ronald P. Stolk,Huib A.P. Pols,Diederick E. Grobbee,Steven W. J. Lamberts +4 more
TL;DR: High fasting serum free IGF-I levels are associated with a decreased presence of atherosclerotic plaques and coronary artery disease and lower serum triglycerides, whereas high fasting IGFBP-1 levels areassociated with a more favorable cardiovascular risk profile.
Journal Article
The risk of spina bifida aperta after first-trimester exposure to valproate in a prenatal cohort
Juliette G. C. Omtzigt,F J Los,Diederick E. Grobbee,L. Pijpers,M G Jahoda,Helen Brandenburg,P. A. Stewart,H L Gaillard,E. S. Sachs,J. W. Wladimiroff +9 more
TL;DR: From results, it is suggested that when the use of VPA during pregnancy cannot be avoided, the teratogenic risk might be diminished by reduction of the daily dose.