D
Diederick E. Grobbee
Researcher at Utrecht University
Publications - 1108
Citations - 136069
Diederick E. Grobbee is an academic researcher from Utrecht University. The author has contributed to research in topics: Population & Risk factor. The author has an hindex of 155, co-authored 1051 publications receiving 122748 citations. Previous affiliations of Diederick E. Grobbee include National Heart Foundation of Australia & Radboud University Nijmegen Medical Centre.
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Journal ArticleDOI
Homeostasis model assessment of insulin resistance and survival in patients with diabetes and acute coronary syndrome
Barbara E. Stähli,Barbara E. Stähli,Anna Nozza,Ilse C. Schrieks,John B. Buse,Klas Malmberg,Linda Mellbin,Bruce Neal,Stephen J. Nicholls,Lars Rydén,Anders Svensson,Hans Wedel,Arlette Weichert,A. Michael Lincoff,Diederick E. Grobbee,Jean-Claude Tardif,Gregory G. Schwartz +16 more
TL;DR: After accounting for levels of NT-proBNP, insulin resistance assessed by HOMA-IR is not related to the risk of death or major adverse cardiovascular events in patients with type 2 diabetes and ACS.
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Adult derived genetic blood pressure scores and blood pressure measured in different body postures in young children.
Maria Ac Jansen,Geertje W. Dalmeijer,Frank L.J. Visseren,Cornelis K. van der Ent,Maarten Leusink,Maarten Leusink,N. Charlotte Onland-Moret,Anke H. Maitland-van der Zee,Diederick E. Grobbee,Cuno S P M Uiterwaal +9 more
TL;DR: Higher scores for adult derived diastolic and systolic BP genes appear to be related to higher supine systolics BP at age 5 years, and Hypertension GRS was not associated with a higher BP in children.
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PTPN1 polymorphisms are associated with total and low-density lipoprotein cholesterol
Florianne Bauer,Onland-Moret N. Charlotte,Anne G. Niehoff,Clara C. Elbers,Diederick E. Grobbee,Cisca Wijmenga,Yvonne T. van der Schouw +6 more
TL;DR: SNPs in the PTPN1 gene are associated with total plasma and LDL cholesterol levels and Haplotypes that comprised these alleles were also borderline statistically significant associated with higher levels of LDL and total cholesterol in men with BMI below 26 kg/m2.
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Combined use of polypill components in patients with type 2 diabetes mellitus
Vivi E Janssen,Frank L.J. Visseren,Anthonius de Boer,Diederick E. Grobbee,Jan Westerink,Yolanda van der Graaf,Melvin Lafeber +6 more
TL;DR: Patients with T2DM frequently use polypill components, often together with oral glucose-lowering agents, and this rate of use has increased steadily between 1996 and 2015, and introducing a cardiovascular or diabetic polypill seems to be highly relevant.
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Extracellular Vesicle cystatin c is associated with unstable angina in troponin negative patients with acute chest pain.
Mirthe Dekker,Mirthe Dekker,Farahnaz Waissi,Farahnaz Waissi,Joelle van Bennekom,Max J. M. Silvis,Nathalie Timmerman,Arjan H. Schoneveld,Diederick E. Grobbee,Robbert J. de Winter,Arend Mosterd,Leo Timmers,Dominique P.V. de Kleijn +12 more
TL;DR: In patients with acute chest pain but low high-sensitive cardiac troponin, lower levels of plasma extracellular vesicle cystatin c are associated with having unstable angina, and this finding is hypothesis generating only considering the small sample size and needs to be confirmed in larger cohort studies.