D
Diederick E. Grobbee
Researcher at Utrecht University
Publications - 1108
Citations - 136069
Diederick E. Grobbee is an academic researcher from Utrecht University. The author has contributed to research in topics: Population & Risk factor. The author has an hindex of 155, co-authored 1051 publications receiving 122748 citations. Previous affiliations of Diederick E. Grobbee include National Heart Foundation of Australia & Radboud University Nijmegen Medical Centre.
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Journal ArticleDOI
Review of moderate alcohol consumption and reduced risk of coronary heart disease: is the effect due to beer, wine, or spirits?
TL;DR: Results from observational studies provide strong evidence that all alcoholic drinks are linked with lower risk, so that much of the benefit is from alcohol rather than other components of each type of drink.
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Effectiveness of antipsychotic drugs in first-episode schizophrenia and schizophreniform disorder: an open randomised clinical trial
René S. Kahn,W. Wolfgang Fleischhacker,Han Boter,Michael Davidson,Yvonne Vergouwe,I. P. M. Keet,Mihai Dumitru Gheorghe,Janusz K. Rybakowski,Silvana Galderisi,Jan Libiger,Martina Hummer,Sonia Dollfus,Juan J. López-Ibor,Luchezar Hranov,Wolfgang Gaebel,Joseph Peuskens,Nils Lindefors,Anita Riecher-Rössler,Diederick E. Grobbee +18 more
TL;DR: This pragmatic trial suggests that clinically meaningful antipsychotic treatment of first-episode of schizophrenia is achievable, for at least 1 year, but it cannot conclude that second-generation drugs are more efficacious than is haloperidol, since discontinuation rates are not necessarily consistent with symptomatic improvement.
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Polysaccharide Conjugate Vaccine against Pneumococcal Pneumonia in Adults
Marc J. M. Bonten,Susanne M. Huijts,Marieke Bolkenbaas,Chris Webber,Scott Patterson,Samantha Gault,Cornelis H. van Werkhoven,Anna M M van Deursen,Elisabeth A. M. Sanders,Theo J M Verheij,Michael Patton,Anne McDonough,Anita Moradoghli-Haftvani,Helen M Smith,Tracey Mellelieu,Michael W. Pride,Graham Crowther,Beate Schmoele-Thoma,Daniel A. Scott,Kathrin U. Jansen,Rita Lobatto,Bas J. Oosterman,Nils Visser,Esther Caspers,Andre J. Smorenburg,Emilio A. Emini,William C. Gruber,Diederick E. Grobbee +27 more
TL;DR: Among older adults, PCV13 was effective in preventing vaccine-type pneumococcal, bacteremic, and noninvasive community-acquired pneumonia and vaccine- type invasive pneumococCal disease but not in preventing community- Acquired pneumonia from any cause.
Journal ArticleDOI
Risk prediction models: II. External validation, model updating, and impact assessment
Karel G.M. Moons,Andre Pascal Kengne,Andre Pascal Kengne,Andre Pascal Kengne,Diederick E. Grobbee,Patrick Royston,Yvonne Vergouwe,Douglas G. Altman,Mark Woodward +8 more
TL;DR: An overview is provided of the consecutive steps for the assessment of the model's predictive performance in new individuals, how to adjust or update existing models to local circumstances or with new predictors, and how to investigate the impact of the uptake of prediction models on clinical decision-making and patient outcomes (impact studies).
Journal ArticleDOI
Long-Term Outcome of Open or Endovascular Repair of Abdominal Aortic Aneurysm
Jorg L. de Bruin,Annette F. Baas,Jaap Buth,Monique Prinssen,Ron Balm,Diederick E. Grobbee,Jan D. Blankensteijn +6 more
TL;DR: Endovascular and open repair of abdominal aortic aneurysm resulted in similar rates of survival six years after randomization, and the rate of secondary interventions was significantly higher for endovascular repair.