Gemma Lombardi

TL;DR: Structural imaging and cognitive changes can be identified 5-10 years before expected onset of symptoms in asymptomatic adults at risk of genetic frontotemporal dementia, which could help to define biomarkers that can stage presymPTomatic disease and track disease progression.

TL;DR: A careful clinical evaluation of sleep disorders should be performed routinely in the clinical setting of persons with cognitive decline, and Instrumental supports should be used only in selected patients.

TL;DR: An international study of age at symptom onset, age at death, and disease duration in individuals with mutations in GRN, MAPT, and C9orf72 to investigate the extent to which variability in age at onset and at death could be accounted for by family membership and the specific mutation carried.

TL;DR: To assess the diagnostic accuracy of structural magnetic resonance imaging for the early diagnosis of dementia due to Alzheimer's disease in people with MCI, Cochrane Dementia and Cognitive Improvement's Specialised Register and the databases was searched and overall measures of relative accuracy in subgroup analyses were obtained.

TL;DR: It is proposed that maintaining the efficient organization of the brain's functional network supports cognitive health even as atrophy and connectivity decline presymptomatically.