Journal ArticleDOI
Genome-wide association scan identifies a colorectal cancer susceptibility locus on chromosome 8q24
Brent W. Zanke,Celia M. T. Greenwood,Celia M. T. Greenwood,Jagadish Rangrej,Rafal Kustra,Rafal Kustra,Albert Tenesa,Susan M. Farrington,James G. D. Prendergast,Sylviane Olschwang,Theodore Chiang,Edgar Crowdy,Vincent Ferretti,Philippe Laflamme,Saravanan Sundararajan,Stéphanie Roumy,Jean François Olivier,Frederick Robidoux,Robert Sladek,Alexandre Montpetit,Peter T. Campbell,Stéphane Bézieau,Anne Marie O'Shea,George Zogopoulos,Michelle Cotterchio,Michelle Cotterchio,Polly A. Newcomb,John R. McLaughlin,John R. McLaughlin,Ban Younghusband,Roger C. Green,Jane Green,Mary Porteous,Harry Campbell,Hélène Blanché,Mourad Sahbatou,Emmanuel Tubacher,Catherine Bonaïti-Pellié,Bruno Buecher,Elio Riboli,Sébastien Küry,Stephen J. Chanock,John D. Potter,Gilles Thomas,Steven Gallinger,Steven Gallinger,Thomas J. Hudson,Thomas J. Hudson,Malcolm G. Dunlop +48 more
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TLDR
Using a multistage genetic association approach comprising 7,480 affected individuals and 7,779 controls, markers in chromosomal region 8q24 associated with colorectal cancer were identified and this locus has been implicated in prostate cancer.Abstract:
Using a multistage genetic association approach comprising 7,480 affected individuals and 7,779 controls, we identified markers in chromosomal region 8q24 associated with colorectal cancer. In stage 1, we genotyped 99,632 SNPs in 1,257 affected individuals and 1,336 controls from Ontario. In stages 2-4, we performed serial replication studies using 4,024 affected individuals and 4,042 controls from Seattle, Newfoundland and Scotland. We identified one locus on chromosome 8q24 and another on 9p24 having combined odds ratios (OR) for stages 1-4 of 1.18 (trend; P = 1.41 x 10(-8)) and 1.14 (trend; P = 1.32 x 10(-5)), respectively. Additional analyses in 2,199 affected individuals and 2,401 controls from France and Europe supported the association at the 8q24 locus (OR = 1.16, trend; 95% confidence interval (c.i.): 1.07-1.26; P = 5.05 x 10(-4)). A summary across all seven studies at the 8q24 locus was highly significant (OR = 1.17, c.i.: 1.12-1.23; P = 3.16 x 10(-11)). This locus has also been implicated in prostate cancer.read more
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Journal ArticleDOI
Molecular Basis of Colorectal Cancer
TL;DR: This review gives an account of recent advances in the authors' knowledge of the molecular mechanisms in colorectal cancer.
Journal ArticleDOI
Association scan of 14,500 nonsynonymous SNPs in four diseases identifies autoimmunity variants
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Journal ArticleDOI
Discovery of cross-reactive probes and polymorphic CpGs in the Illumina Infinium HumanMethylation450 microarray
Yi-an Chen,Mathieu Lemire,Sanaa Choufani,Darci T. Butcher,Daria Grafodatskaya,Brent W. Zanke,Steven Gallinger,Thomas J. Hudson,Rosanna Weksberg +8 more
TL;DR: 6% of the array probes can potentially generate spurious signals because of co-hybridization to alternate genomic sequences highly homologous to the intended targets, which could lead investigators to mistakenly infer the existence of significant autosomal sex-associated methylation.
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Linkage disequilibrium -understanding the evolutionary past and mapping the medical future
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Genome-wide association study of prostate cancer identifies a second risk locus at 8q24
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