U
Ursula M. Schick
Researcher at Icahn School of Medicine at Mount Sinai
Publications - 33
Citations - 2617
Ursula M. Schick is an academic researcher from Icahn School of Medicine at Mount Sinai. The author has contributed to research in topics: Genome-wide association study & Exome. The author has an hindex of 23, co-authored 33 publications receiving 2192 citations. Previous affiliations of Ursula M. Schick include National Institutes of Health & University of Washington.
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Journal ArticleDOI
Inactivating mutations in NPC1L1 and protection from coronary heart disease
Nathan O. Stitziel,Hong-Hee Won,Alanna C. Morrison,Gina M. Peloso,Ron Do,Leslie A. Lange,Pierre Fontanillas,Namrata Gupta,Stefano Duga,Anuj Goel,Martin Farrall,Danish Saleheen,Paola G. Ferrario,Inke R. König,Rosanna Asselta,Piera Angelica Merlini,Nicola Marziliano,Maria Francesca Notarangelo,Ursula M. Schick,Paul L. Auer,Themistocles L. Assimes,Muredach P. Reilly,Robert L. Wilensky,Daniel J. Rader,G. Kees Hovingh,Thomas Meitinger,Thorsten Kessler,Adnan Kastrati,Karl-Ludwig Laugwitz,David S. Siscovick,Jerome I. Rotter,Stanley L. Hazen,Russell P. Tracy,Sharon Cresci,John A. Spertus,Rebecca D. Jackson,Stephen M. Schwartz,Pradeep Natarajan,Jacy R Crosby,Donna M. Muzny,Christie M. Ballantyne,Stephen S. Rich,Christopher J. O'Donnell,Gonçalo R. Abecasis,Shamil R. Sunyaev,Deborah A. Nickerson,Julie E. Buring,Paul M. Ridker,Daniel I. Chasman,Erin Austin,Zi Ye,Iftikhar J. Kullo,Peter Weeke,Christian M. Shaffer,Lisa Bastarache,Joshua C. Denny,Dan M. Roden,Colin N. A. Palmer,Panos Deloukas,Danyu Lin,Zheng-Zheng Tang,Jeanette Erdmann,Heribert Schunkert,John Danesh,Jaume Marrugat,Roberto Elosua,Diego Ardissino,Ruth McPherson,Hugh Watkins,Alexander P. Reiner,James G. Wilson,David Altshuler,Richard A. Gibbs,Eric S. Lander,Eric Boerwinkle,Stacey Gabriel,Sekar Kathiresan +76 more
TL;DR: In this paper, the exons of the Niemann-Pick C1-like 1 (NPC1L1) protein were sequenced in 7364 patients with coronary heart disease and in 14,728 controls without such disease who were of European, African or South Asian ancestry.
Journal ArticleDOI
Coding Variation in ANGPTL4, LPL, and SVEP1 and the Risk of Coronary Disease
Nathan O. Stitziel,Kathleen Stirrups,Nicholas G. D. Masca,Jeanette Erdmann,Paola G. Ferrario,Inke R. Koenig,Peter Weeke,Tom R. Webb,Paul L. Auer,Ursula M. Schick,Yingchang Lu,He Zhang,Marie-Pierre Dubé,Anuj Goel,Martin Farrall,Gina M. Peloso,Hong-Hee Won,Ron Do,Erik P A Van Iperen,Stavroula Kanoni,Jochen Kruppa,Anubha Mahajan,Robert A. Scott,Christina Willenborg,Peter S. Braund,Julian C. van Capelleveen,Alex S. F. Doney,Louise A. Donnelly,Rosanna Asselta,Piera Angelica Merlini,Stefano Duga,Nicola Marziliano,Josh C. Denny,Christian M. Shaffer,Nour Eddine El-Mokhtari,Andre Franke,Omri Gottesman,Stefanie Heilmann,Christian Hengstenberg,Per Hoffmann,Oddgeir L. Holmen,Kristian Hveem,Jan-Håkan Jansson,Karl-Heinz Joeckel,Thorsten Kessler,Jennifer Kriebel,Karl L. Laugwitz,Eirini Marouli,Nicola Martinelli,Mark I. McCarthy,Natalie R. van Zuydam,Christa Meisinger,Tõnu Esko,Evelin Mihailov,Stefan A. Escher,Maris Alver,Susanne Moebus,Andrew D. Morris,Martina Mueller-Nurasyid,Majid Nikpay,Oliviero Olivieri,Louis-Philippe Lemieux Perreault,Alaa AlQarawi,Neil R. Robertson,Karen O. Akinsanya,Dermot F. Reilly,Thomas F. Vogt,Wu Yin,Folkert W. Asselbergs,Charles Kooperberg,Rebecca D. Jackson,Eli A. Stahl,Konstantin Strauch,Tibor V. Varga,Melanie Waldenberger,Lingyao Zeng,Aldi T. Kraja,Chunyu Liu,Georg Ehret,Christopher Newton-Cheh,Daniel I. Chasman,Rajiv Chowdhury,Marco M Ferrario,Ian Ford,J. Wouter Jukema,Frank Kee,Kari Kuulasmaa,Børge G. Nordestgaard,Markus Perola,Danish Saleheen,Naveed Sattar,Praveen Surendran,David-Alexandre Trégouët,Robin Young,Joanna M. M. Howson,Adam S. Butterworth,John Danesh,Diego Ardissino,Erwin P. Bottinger,Raimund Erbel,Paul W. Franks,Domenico Girelli,Alistair S. Hall,G. Kees Hovingh,Adnan Kastrati,Wolfgang Lieb,Thomas Meitinger,William E. Kraus,Svati H. Shah,Ruth McPherson,Marju Orho-Melander,Olle Melander,Andres Metspalu,Colin N. A. Palmer,Annette Peters,Daniel J. Rader,Muredach P. Reilly,Ruth J. F. Loos,Alexander P. Reiner,Dan M. Roden,Jean-Claude Tardif,John R. Thompson,Nicholas J. Wareham,Hugh Watkins,Cristen J. Willer,Sekar Kathiresan,Panos Deloukas,Nilesh J. Samani,Heribert Schunkert +128 more
TL;DR: It was found that carriers of loss-of-function mutations in ANGPTL4 had triglyceride levels that were lower than those among noncarriers; these mutations were also associated with protection from coronary artery disease.
Journal ArticleDOI
Large-scale genomic analyses link reproductive aging to hypothalamic signaling, breast cancer susceptibility and BRCA1-mediated DNA repair
Felix R. Day,Katherine S. Ruth,Deborah J. Thompson,Kathryn L. Lunetta,Natalia Pervjakova,Daniel I. Chasman,Lisette Stolk,Hilary K. Finucane,Patrick Sulem,Brendan Bulik-Sullivan,Tõnu Esko,Andrew D. Johnson,Cathy E. Elks,Nora Franceschini,Chunyan He,Elisabeth Altmaier,Jennifer A. Brody,Lude Franke,Jennifer E. Huffman,Margaux F. Keller,Patrick F. McArdle,Teresa Nutile,Eleonora Porcu,Antonietta Robino,Lynda M. Rose,Ursula M. Schick,Jennifer A. Smith,Alexander Teumer,Michela Traglia,Dragana Vuckovic,Jie Yao,Wei Zhao,Eva Albrecht,Najaf Amin,Tanguy Corre,Jouke-Jan Hottenga,Massimo Mangino,Albert V. Smith,Toshiko Tanaka,Goncąlo R. Abecasis,Irene L. Andrulis,Hoda Anton-Culver,Antonis C. Antoniou,Volker Arndt,Alice M. Arnold,Caterina Barbieri,Matthias W. Beckmann,Alicia Beeghly-Fadiel,Javier Benitez,Leslie Bernstein,Suzette J. Bielinski,Carl Blomqvist,Eric Boerwinkle,Natalia Bogdanova,S.E. Bojesen,Manjeet K. Bolla,Anne Lise Børresen-Dale,Thibaud Boutin,Hiltrud Brauch,Hermann Brenner,Thomas Brüning,Barbara Burwinkel,Archie Campbell,Harry Campbell,Stephen J. Chanock,J. Ross Chapman,Yii-Der Ida Chen,Georgia Chenevix-Trench,Fergus J. Couch,Andrea D. Coviello,Angela Cox,Kamila Czene,Hatef Darabi,Immaculata De Vivo,Ellen W. Demerath,Joe Dennis,Peter Devilee,Thilo Dörk,Isabel dos-Santos-Silva,Alison M. Dunning,John D. Eicher,P. A. Fasching,Jessica D. Faul,Jonine D. Figueroa,Dieter Flesch-Janys,Ilaria Gandin,Melissa E. Garcia,Montserrat Garcia-Closas,Graham G. Giles,Giorgia Girotto,Mark S. Goldberg,Anna González-Neira,Mark O. Goodarzi,Megan L. Grove,D. F. Gudbjartsson,Pascal Guenel,Xiuqing Guo,Christopher A. Haiman,Per Hall,U Hamann,Brian E. Henderson,Lynne J. Hocking,Albert Hofman,Georg Homuth,Maartje J. Hooning,John L. Hopper,Frank B. Hu,Jinyan Huang,Keith Humphreys,David J. Hunter,Anna Jakubowska,Samuel E. Jones,Maria Kabisch,David Karasik,Julia A. Knight,Ivana Kolcic,Charles Kooperberg,Veli-Matti Kosma,Jennifer Kriebel,Vessela N. Kristensen,Diether Lambrechts,Claudia Langenberg,Jingmei Li,Xin Li,Sara Lindström,Yongmei Liu,Jian'an Luan,Jan Lubinski,Reedik Mägi,Arto Mannermaa,Judith Manz,Sara Margolin,Jonathan Marten,Nicholas G. Martin,Corrado Masciullo,A. Meindl,Kyriaki Michailidou,E. Mihailov,Lili Milani,Roger L. Milne,Martina Müller-Nurasyid,Mike A. Nalls,Benjamin M. Neale,Benjamin M. Neale,Heli Nevanlinna,Patrick Neven,Anne B. Newman,Børge G. Nordestgaard,Janet E. Olson,Sandosh Padmanabhan,Paolo Peterlongo,Ulrike Peters,Astrid Petersmann,Julian Peto,Paul D.P. Pharoah,Nicola Pirastu,Ailith Pirie,Giorgio Pistis,Ozren Polasek,David J. Porteous,Bruce M. Psaty,Katri Pylkäs,Paolo Radice,Leslie J. Raffel,Fernando Rivadeneira,Igor Rudan,Anja Rudolph,Daniela Ruggiero,Cinzia Sala,Serena Sanna,Elinor J. Sawyer,David Schlessinger,Marjanka K. Schmidt,Frank Schmidt,Rita K. Schmutzler,Minouk J. Schoemaker,Robert A. Scott,Caroline Seynaeve,Jacques Simard,Rossella Sorice,Melissa C. Southey,Doris Stöckl,Konstantin Strauch,Anthony J. Swerdlow,Kent D. Taylor,Unnur Thorsteinsdottir,Amanda E. Toland,Ian Tomlinson,Thérèse Truong,Laufey Tryggvadottir,Stephen Turner,Diego Vozzi,Qin Wang,Melissa Wellons,Gonneke Willemsen,James F. Wilson,Robert Winqvist,Bruce H. R. Wolffenbuttel,A. F. Wright,Drakoulis Yannoukakos,Tatijana Zemunik,Wei Zheng,Marek Zygmunt,Sven Bergmann,Dorret I. Boomsma,Julie E. Buring,Luigi Ferrucci,Grant W. Montgomery,Vilmundur Gudnason,Tim D. Spector,Cornelia M. van Duijn,Behrooz Z. Alizadeh,Marina Ciullo,Laura Crisponi,Douglas F. Easton,Paolo Gasparini,Christian Gieger,Tamara B. Harris,Caroline Hayward,Sharon L.R. Kardia,Peter Kraft,Barbara McKnight,Andres Metspalu,Alanna C. Morrison,Alexander P. Reiner,Paul M. Ridker,Jerome I. Rotter,Daniela Toniolo,André G. Uitterlinden,Sheila Ulivi,Henry Völzke,Nicholas J. Wareham,David R. Weir,Laura M. Yerges-Armstrong,Alkes L. Price,Kari Stefansson,Jenny A. Visser,Ken K. Ong,Jenny Chang-Claude,Joanne M. Murabito,John R. B. Perry,Anna Murray +241 more
TL;DR: A dual strategy to identify common and low-frequency protein-coding variation associated with age at natural menopause and enrichment of signals in or near genes involved in delayed puberty are reported, highlighting the first molecular links between the onset and end of reproductive lifespan.
Journal ArticleDOI
Systematic Evaluation of Pleiotropy Identifies 6 Further Loci Associated With Coronary Artery Disease
Tom R. Webb,Jeanette Erdmann,Kathleen Stirrups,Nathan O. Stitziel,Nicholas G. D. Masca,Henning Jansen,Stavroula Kanoni,Christopher P. Nelson,Paola G. Ferrario,Inke R. König,John D. Eicher,Andrew D. Johnson,Stephen E. Hamby,Christer Betsholtz,Arno Ruusalepp,Oscar Franzén,Eric E. Schadt,Johan Björkegren,Peter Weeke,Paul L. Auer,Ursula M. Schick,Ursula M. Schick,Yingchang Lu,He Zhang,Marie-Pierre Dubé,Anuj Goel,Martin Farrall,Gina M. Peloso,Hong-Hee Won,Ron Do,Erik P A Van Iperen,Jochen Kruppa,Anubha Mahajan,Robert A. Scott,Christina Willenborg,Peter S. Braund,Julian C. van Capelleveen,Alex S. F. Doney,Louise A. Donnelly,Rosanna Asselta,Pier Angelica Merlini,Stefano Duga,Nicola Marziliano,Josh C. Denny,Christian M. Shaffer,Nour Eddine El-Mokhtari,Andre Franke,Stefanie Heilmann,Christian Hengstenberg,Per Hoffmann,Oddgeir L. Holmen,Kristian Hveem,Jan-Håkan Jansson,Karl-Heinz Jöckel,Thorsten Kessler,Jennifer Kriebel,Karl L. Laugwitz,Eirini Marouli,Nicola Martinelli,Mark I. McCarthy,Natalie R. van Zuydam,Christa Meisinger,Tõnu Esko,Tõnu Esko,Tõnu Esko,Evelin Mihailov,Stefan A. Escher,Maris Alver,Susanne Moebus,Andrew D. Morris,Jarma Virtamo,Majid Nikpay,Oliviero Olivieri,Sylvie Provost,Alaa AlQarawi,Neil R. Robertson,Karen O. Akinsansya,Dermot F. Reilly,Thomas F. Vogt,Wu Yin,Folkert W. Asselbergs,Folkert W. Asselbergs,Charles Kooperberg,Rebecca D. Jackson,Eli A. Stahl,Martina Müller-Nurasyid,Konstantin Strauch,Tibor V. Varga,Melanie Waldenberger,Lingyao Zeng,Rajiv Chowdhury,Veikko Salomaa,Ian Ford,J. Wouter Jukema,Philippe Amouyel,Jukka Kontto,Børge G. Nordestgaard,Jean Ferrières,Danish Saleheen,Naveed Sattar,Praveen Surendran,Aline Wagner,Robin Young,Joanna M. M. Howson,Adam S. Butterworth,John Danesh,Diego Ardissino,Erwin P. Bottinger,Raimund Erbel,Paul W. Franks,Domenico Girelli,Alistair S. Hall,G. Kees Hovingh,Adnan Kastrati,Wolfgang Lieb,Thomas Meitinger,William E. Kraus,Svati H. Shah,Ruth McPherson,Marju Orho-Melander,Olle Melander,Andres Metspalu,Colin N. A. Palmer,Annette Peters,Daniel J. Rader,Muredach P. Reilly,Ruth J. F. Loos,Alexander P. Reiner,Alexander P. Reiner,Dan M. Roden,Jean-Claude Tardif,John R. Thompson,Nicholas J. Wareham,Hugh Watkins,Cristen J. Willer,Nilesh J. Samani,Heribert Schunkert,Panos Deloukas,Sekar Kathiresan +138 more
TL;DR: Several CAD loci show substantial pleiotropy, which may help us understand the mechanisms by which these loci affect CAD risk, and identify 6 new loci associated with CAD at genome-wide significance.
Journal ArticleDOI
Genome-wide meta-analysis uncovers novel loci influencing circulating leptin levels
Tuomas O. Kilpeläinen,Tuomas O. Kilpeläinen,Tuomas O. Kilpeläinen,Jayne F. Martin Carli,Alicja A. Skowronski,Qi Sun,Qi Sun,Jennifer Kriebel,Mary F. Feitosa,Åsa K. Hedman,Åsa K. Hedman,Åsa K. Hedman,Alexander W. Drong,James E. Hayes,James E. Hayes,Jing Hua Zhao,Tune H. Pers,Ursula M. Schick,Niels Grarup,Zoltán Kutalik,Zoltán Kutalik,Stella Trompet,Massimo Mangino,Massimo Mangino,Kati Kristiansson,Kati Kristiansson,Marian Beekman,Leo-Pekka Lyytikäinen,Joel Eriksson,Peter Henneman,Peter Henneman,Jari Lahti,Toshiko Tanaka,Jian'an Luan,Fabiola Del Greco M,Dorota Pasko,Frida Renström,Frida Renström,Sara M. Willems,Anubha Mahajan,Lynda M. Rose,Xiuqing Guo,Yongmei Liu,Marcus E. Kleber,Louis Pérusse,Tom R. Gaunt,Tarunveer S. Ahluwalia,Tarunveer S. Ahluwalia,Yun Ju Sung,Yolande F. M. Ramos,Najaf Amin,Antoinette Amuzu,Inês Barroso,Inês Barroso,Claire Bellis,Claire Bellis,Claire Bellis,John Blangero,Brendan M. Buckley,Stefan Böhringer,Yii-Der Ida Chen,Anton J. N. de Craen,David R. Crosslin,Caroline Dale,Zari Dastani,Felix R. Day,Joris Deelen,Graciela E. Delgado,Ayse Demirkan,Ayse Demirkan,Francis M. Finucane,Ian Ford,Melissa E. Garcia,Christian Gieger,Stefan Gustafsson,Stefan Gustafsson,Göran Hallmans,Susan E. Hankinson,Susan E. Hankinson,Susan E. Hankinson,Aki S. Havulinna,Christian Herder,Dena G. Hernandez,Andrew A. Hicks,David J. Hunter,Thomas Illig,Erik Ingelsson,Erik Ingelsson,Erik Ingelsson,Andrea Ioan-Facsinay,John-Olov Jansson,Nancy S. Jenny,Marit E. Jørgensen,Torben Jørgensen,Torben Jørgensen,Torben Jørgensen,Magnus Karlsson,Wolfgang Koenig,Wolfgang Koenig,Peter Kraft,J.C. Kwekkeboom,Tiina Laatikainen,Tiina Laatikainen,Karl-Heinz Ladwig,Charles A. LeDuc,Gordon D.O. Lowe,Yingchang Lu,Pedro Marques-Vidal,Christina Meisinger,Cristina Menni,Andrew P. Morris,Andrew P. Morris,Richard H. Myers,Satu Männistö,Mike A. Nalls,Lavinia Paternoster,Annette Peters,Aruna D. Pradhan,Aruna D. Pradhan,Tuomo Rankinen,Laura J. Rasmussen-Torvik,Wolfgang Rathmann,Treva Rice,J. Brent Richards,J. Brent Richards,Paul M. Ridker,Paul M. Ridker,Naveed Sattar,David B. Savage,Stefan Söderberg,Nicholas J. Timpson,Liesbeth Vandenput,Diana van Heemst,Hae-Won Uh,Marie-Claude Vohl,Mark Walker,Heinz-Erich Wichmann,Heinz-Erich Wichmann,Elisabeth Widen,Andrew R. Wood,Jie Yao,Tanja Zeller,Yiying Zhang,Ingrid Meulenbelt,Margreet Kloppenburg,Arne Astrup,Thorkild I. A. Sørensen,Mark A. Sarzynski,Dabeeru C. Rao,Pekka Jousilahti,Erkki Vartiainen,Albert Hofman,Fernando Rivadeneira,André G. Uitterlinden,Eero Kajantie,Eero Kajantie,Eero Kajantie,Clive Osmond,Aarno Palotie,Aarno Palotie,Aarno Palotie,Johan G. Eriksson,Johan G. Eriksson,Markku Heliövaara,Paul Knekt,Seppo Koskinen,Antti Jula,Markus Perola,Markus Perola,Markus Perola,Risto Huupponen,Risto Huupponen,Jorma Viikari,Jorma Viikari,Mika Kähönen,Terho Lehtimäki,Olli T. Raitakari,Olli T. Raitakari,Dan Mellström,Mattias Lorentzon,Juan P. Casas,Stefania Bandinelli,Winfried März,Winfried März,Winfried März,Aaron Isaacs,Ko Willems van Dijk,Cornelia M. van Duijn,Tamara B. Harris,Claude Bouchard,Matthew A. Allison,Daniel I. Chasman,Daniel I. Chasman,Claes Ohlsson,Lars Lind,Robert A. Scott,Claudia Langenberg,Nicholas J. Wareham,Luigi Ferrucci,Timothy M. Frayling,Peter P. Pramstaller,Ingrid B. Borecki,Dawn M. Waterworth,Sven Bergmann,Sven Bergmann,Gérard Waeber,Peter Vollenweider,Henrik Vestergaard,Henrik Vestergaard,Torben Hansen,Torben Hansen,Oluf Pedersen,Frank B. Hu,P. Eline Slagboom,Harald Grallert,Tim D. Spector,Joop Jukema,Robert J. Klein,Eric E. Schadt,Paul W. Franks,Paul W. Franks,Paul W. Franks,Cecilia M. Lindgren,Cecilia M. Lindgren,Cecilia M. Lindgren,Rudolph L. Leibel,Ruth J. F. Loos,Ruth J. F. Loos +227 more
TL;DR: In this article, the authors performed a genome-wide association study (GWAS) of circulating leptin levels from 32,161 individuals and identified five loci robustly associated with leptin levels in/near LEP, SLC32A1, GCKR, CCNL1 and FTO.