J
John M. Pezzuto
Researcher at Long Island University
Publications - 599
Citations - 38474
John M. Pezzuto is an academic researcher from Long Island University. The author has contributed to research in topics: Cancer & Resveratrol. The author has an hindex of 88, co-authored 588 publications receiving 35901 citations. Previous affiliations of John M. Pezzuto include Purdue University & Bandung Institute of Technology.
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Journal Article
Structure-activity relationships of brassinin in preventing the development of carcinogen-induced mammary lesions in organ culture.
Rajendra G. Mehta,Liu J,Andreas I. Constantinou,Michael E. Hawthorne,John M. Pezzuto,Richard C. Moon,Robert M. Moriarty +6 more
TL;DR: Several analogs of brassinin were synthesized and evaluated their effectiveness in the mouse mammary gland organ culture model and showed that cyclobrassinin, also a naturally occurring Brassinin analog, was more effective than brassinIn.
Journal ArticleDOI
Resveratrol: Twenty Years of Growth, Development and Controversy
TL;DR: Although the ultimate fate of resveratrol remains an open question, thus far, the compound has inspired innovative scientific concepts and enhanced public awareness of preventative health care.
BookDOI
Biotechnology and Pharmacy
TL;DR: Biotechnology and pharmacy, Biotechnology and Pharmacy, مرکز فناوری اطلاعات و £1,000,000; اوشاوρزی رسانی, کسورز, امیران, یکدرام;
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Composition of a chemopreventive proanthocyanidin-rich fraction from cranberry fruits responsible for the inhibition of 12-O-tetradecanoyl phorbol-13-acetate (TPA)-induced ornithine decarboxylase (ODC) activity.
Fayez E. Kandil,Mary Ann L. Smith,Randy B. Rogers,Marie-France Pepin,Lynda L. Song,John M. Pezzuto,David S. Seigler +6 more
TL;DR: Antioxidant activity was not restricted to a particular class of components in the extract but was found in a wide range of the fractions, and significant chemopreventive activity was localized in one particular proanthocyanidin-rich fraction from the initial fractionation procedure.
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Synthesis and biological evaluation of (+/-)-abyssinone II and its analogues as aromatase inhibitors for chemoprevention of breast cancer.
Arup Maiti,Muriel Cuendet,Vicki L. Croy,Denise Coutinho Endringer,John M. Pezzuto,Mark Cushman +5 more
TL;DR: The most active flavanone of the series was 20 times more potent than (+/-)-abyssinone II (IC50 40.95 microM), and further smaller increases in activity resulted from the methylation of the 7-hydroxyl group and removal of the prenyl side chain.