J
John M. Pezzuto
Researcher at Long Island University
Publications - 599
Citations - 38474
John M. Pezzuto is an academic researcher from Long Island University. The author has contributed to research in topics: Cancer & Resveratrol. The author has an hindex of 88, co-authored 588 publications receiving 35901 citations. Previous affiliations of John M. Pezzuto include Purdue University & Bandung Institute of Technology.
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Pervilleine A, a novel tropane alkaloid that reverses the multidrug-resistance phenotype.
Qiuwen Mi,Baoliang Cui,Gloria L. Silva,Daniel D. Lantvit,Eula Lim,Heebyung Chai,Min You,Melinda G. Hollingshead,Joseph G. Mayo,A. Douglas Kinghorn,John M. Pezzuto +10 more
TL;DR: Pervilleine A, a novel tropane alkaloid obtained from a chloroform extract of Erythroxylum pervillei as the result of bioactivity-guided fractionation, was found to restore the vinblastine sensitivity of cultured multidrug-resistant KB-V1 and CEM/VLB(100) cells, and should be further evaluated for clinical utility.
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Biological Activity of Novel Macrocyclic Alkaloids (Budmunchiamines) from Albizia amara Detected on the Basis of Interaction with DNA
W. Mar,Ghee Teng Tan,Geoffrey A. Cordell,John M. Pezzuto,K. Jurcic,Franziska Offermann,Karl Redl,Bernice Steinke,Hildebert Wagner +8 more
TL;DR: Investigation led to the procurement of four sets of alkaloid isolates X1-X4 that were found to be macrocyclic pithecolobine alkaloids that were generally cytotoxic with a battery of cultured mammalian cells.
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Quinone-methide triterpenes and salaspermic acid from Kokoona ochracea.
TL;DR: The quinone-methide triterpenes 1-3 exhibited strong but non-specific in vitro cytotoxicity against P-388 murine lymphocytic leukemia cells and a panel of human cancer cell lines.
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Activity-guided fractionation of the seeds of Ziziphus jujuba using a cyclooxygenase-2 inhibitory assay
Bao-Ning Su,Muriel Cuendet,Norman R. Farnsworth,Harry H. S. Fong,John M. Pezzuto,A. Douglas Kinghorn +5 more
TL;DR: Bioactivity-guided fractionation of petroleum ether- and EtOAc-soluble extracts of the seeds of Ziziphus jujuba using a cyclooxygenase-2 assay as a monitor indicated that the triglyceride, 1,3-di-O-[9(Z)-octadecenoyl]glycerol (3), and a fatty acid mixture of linoleic, oleic and stearic acids, were the major active components.
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Antimutagenic Constituents of Casimiroa edulis with Potential Cancer Chemopreventive Activity
Aiko Ito,Lisa A. Shamon,Boyang Yu,E. Mata-Greenwood,Sang Kook Lee,Richard B. van Breemen,Rajendra G. Mehta,Norman R. Farnsworth,Harry H. S. Fong,John M. Pezzuto,A. Douglas Kinghorn +10 more
TL;DR: An ethyl acetate extract derived from the seeds of the medicinal and food plant Casimiroa edulis inhibited mutagenicity induced by 7,12-dimethylbenz[a]anthracene (DMBA) with Salmonella typhimurium strain TM677 as mentioned in this paper.