J
John M. Pezzuto
Researcher at Long Island University
Publications - 599
Citations - 38474
John M. Pezzuto is an academic researcher from Long Island University. The author has contributed to research in topics: Cancer & Resveratrol. The author has an hindex of 88, co-authored 588 publications receiving 35901 citations. Previous affiliations of John M. Pezzuto include Purdue University & Bandung Institute of Technology.
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Journal ArticleDOI
Evaluation Of Selected Lichens From Iceland For Cancer Chemopreventive And Cytotoxic Activity
K. Ingólfsdóttir,Kook Lee Sang Kook Lee,Krishna P L Bhat,K. Lee,H. B. Chai,H. Kristinsson,L. L. Song,J. Gills,J. Th Gudmundsdottir,E. Mata-Greenwood,M. S. Jang,John M. Pezzuto +11 more
TL;DR: Organic extracts tested for potential to induce quinone reductase (QR) and differentiation of human promyelocytic leukemia (HL-60) cells, inhibit cyclooxygenase-1 (COX-1), phorbol ester-induced ornithine decarboxylase (ODC), aromatase and sulfatase, as well as for antioxidant, estrogenic/anti-estrogenic and antiproliferative activity were evaluated.
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Novel cytotoxic labdane diterpenoids from Neouvaria acuminatissima
Ik-Soo Lee,Xianjian Ma,Heebyung Chai,Domingo A. Madulid,R. Brian Lamont,Melanie J. O'Neill,Jeffrey M. Besterman,Norman R. Farnsworth,Djaja D. Soejarto,Geoffrey A. Cordell,John M. Pezzuto,A. Douglas Kinghorn +11 more
TL;DR: In this paper, a cytotoxic labdane diterpene with a new type of carbon skeleton was isolated from the stem bark of Neouvaria acuminatissima, together with its congeners 17-O-acetylacuminolide and an inactive derivative, spiroacuminolate.
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Design, synthesis, and biological evaluation of callophycin A and analogues as potential chemopreventive and anticancer agents.
Li Shen,Eun-Jung Park,Tamara P. Kondratyuk,Daniela Guendisch,Laura Marler,John M. Pezzuto,Anthony D. Wright,Dianqing Sun +7 more
TL;DR: A tetrahydro-β-carboline-based template inspired by callophycin A was employed for production of a chemical library and biological results showed that the n-pentyl urea S-isomer 6a was the strongest inducer of QR1 with an induction ratio (IR) value of 4.9.
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1', 2', 3', 4'-Tetradehydrotubulosine, a cytotoxic alkaloid from Pogonopus speciosus
Aiko Ito,Lee Yh,Heebyung Chai,Mahabir P. Gupta,Norman R. Farnsworth,Geoffrey A. Cordell,John M. Pezzuto,A. D. Kinghorn +7 more
TL;DR: Alkaloids 1 and 3 showed weak cytotoxic activity against a panel of human cancer cell lines, with the potency of these compounds being markedly less than that of tubulosine (2).
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Bruceantin inhibits multiple myeloma cancer stem cell proliferation.
TL;DR: In this study, BCT was shown to be an effective agent in controlling the proliferation, viability and migration of MM-CSCs as well as angiogenesis in vitro and may be mediated by the Notch pathway.