J
John M. Pezzuto
Researcher at Long Island University
Publications - 599
Citations - 38474
John M. Pezzuto is an academic researcher from Long Island University. The author has contributed to research in topics: Cancer & Resveratrol. The author has an hindex of 88, co-authored 588 publications receiving 35901 citations. Previous affiliations of John M. Pezzuto include Purdue University & Bandung Institute of Technology.
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Antiplasmodial and Cytotoxic Activity of Natural Bisbenzylisoquinoline Alkaloids
TL;DR: As part of an ongoing collaborative effort to discover new antimalarial agents from natural sources, 53 bisbenzylisoquinoline alkaloids are tested for cytotoxicity against cultured mammalian cells and for antiplasmodial activity against chloroquine-sensitive and chloroquin-resistant clones of Plasmodium falciparum.
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Metabolically activated steviol, the aglycone of stevioside, is mutagenic
TL;DR: It is clear that a metabolite of an integral component of stevioside is mutagenic; structural features of requisite importance for the expression of mutagening activity include a hydroxy group at position 13 and an unsaturated bond joining the carbon atoms at positions 16 and 17.
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Chemical and bioactive constituents from Zanthoxylum simulans
Ih-Sheng Chen,Shwu Jen Wu,Ian Lih Tsai,Tian Shung Wu,John M. Pezzuto,Matthias C. Lu,Heebyung Chai,Nanjoo Suh,Che-Ming Teng +8 more
TL;DR: Two new benzo[c]phenanthridine alkaloids and 6-methyldihydrochelerythrine, together with 23 known compounds, were isolated from the root bark of Zanthoxylum simulans and exhibited cytotoxic activity.
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Sulforaphane prevents mouse skin tumorigenesis during the stage of promotion
Joell J. Gills,Elizabeth H. Jeffery,Nathan V. Matusheski,Richard C. Moon,Daniel D. Lantvit,John M. Pezzuto +5 more
TL;DR: Topical Sulforaphane inhibited TPA-induced ornithine decarboxylase activity in mouse skin, an obligate step in Tpa-induced promotion of carcinogenesis, linking this molecular mechanism to SF-dependent inhibition of the promotion of tumorigenesis.
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Constituents of the bark and twigs of Artocarpus dadah with cyclooxygenase inhibitory activity.
Bao-Ning Su,Muriel Cuendet,Michael E. Hawthorne,Leonardus B.S. Kardono,Soedarsono Riswan,Harry H. S. Fong,Rajendra G. Mehta,John M. Pezzuto,A. Douglas Kinghorn +8 more
TL;DR: From an ethyl acetate-soluble extract of the twigs of the same plant were isolated compound 4 and two new neolignan derivatives, dadahols A and B, as well as 10 known compounds, oxyresveratrol, (+)-catechin, afzelechin-3-O-alpha-L-rhamnopyranoside, resveratro, steppogenin, moracin M, isogemichalcone