J
John M. Pezzuto
Researcher at Long Island University
Publications - 599
Citations - 38474
John M. Pezzuto is an academic researcher from Long Island University. The author has contributed to research in topics: Cancer & Resveratrol. The author has an hindex of 88, co-authored 588 publications receiving 35901 citations. Previous affiliations of John M. Pezzuto include Purdue University & Bandung Institute of Technology.
Papers
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Journal ArticleDOI
Potential anti-AIDS naphthalenesulfonic acid derivatives. Synthesis and inhibition of HIV-1 induced cytopathogenesis and HIV-1 and HIV-2 reverse transcriptase activities.
Ghee Teng Tan,Anura Wickramasinghe,Sandeep Verma,Rajendra Singh,Stephen H. Hughes,John M. Pezzuto,Masanori Baba,Prem Mohan +7 more
TL;DR: The influence of the palmitoyl functionality in the naphthalenedisulfonic acid series to confer activity against both HIV-1 and HIV-2 RT is most striking.
Patent
Method and composition for treating cancers
Tapas K. Dasgupta,Darrick S. H. L. Kim,Konrad Marc Kuzmanoff,Ling-Indeck Lydia,John M. Pezzuto,Mary Lou Schmidt +5 more
TL;DR: In this paper, a composition and method of preventing or inhibiting tumor growth, and of treating malignant cancers without toxic side effects are disclosed, and the active compound of the composition is either a Betulinic acid or a Betulusic acid derivative.
Journal ArticleDOI
2-substituted furans from Polyalthia suberosa.
Patoomratana Tuchinda,Manat Pohmakotr,Vichai Reutrakul,Wanpen Thanyachareon,Samaisukh Sophasan,Chalobon Yoosook,Thawatchai Santisuk,John M. Pezzuto +7 more
TL;DR: Two new 2-substituted furans, 1-( 2-furyl)pentacosa-16,18-diyne and 23-(2-furies)tricosa-5,7-diynoic acid, isolated from stems of Polyalthia suberosa showed anti-HIV activities.
Journal ArticleDOI
Evaluation of Flavonoid and Resveratrol Chemical Libraries Reveals Abyssinone II as a Promising Antibacterial Lead
TL;DR: Preliminary mechanistic studies revealed that abyssinone II hyperpolarizes the bacterial membrane potential and inhibits the biosynthesis of key cellular macromolecules (DNA, RNA, and protein).
Journal ArticleDOI
Thalifaberidine, a cytotoxic aporphine-benzylisoquinoline alkaloid from Thalictrum faberi.
Long Ze Lin,Shu-Fang Hu,Kyaw Zaw,Cindy K. Angerhofer,Heebyung Chai,John M. Pezzuto,Geoffrey A. Cordell,Jing Lin,Ding-Ming Zheng +8 more
TL;DR: Thalifaberidine, thal ifaberine, and thalifasine showed cytotoxic activity against several human cancer cell lines, as well as antimalarial activity.