J
John M. Pezzuto
Researcher at Long Island University
Publications - 599
Citations - 38474
John M. Pezzuto is an academic researcher from Long Island University. The author has contributed to research in topics: Cancer & Resveratrol. The author has an hindex of 88, co-authored 588 publications receiving 35901 citations. Previous affiliations of John M. Pezzuto include Purdue University & Bandung Institute of Technology.
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Evaluation of the cytotoxic mechanism mediated by baccatin III, the synthetic precursor of taxol
TL;DR: Baccatin III, which is used as a precursor for the semisynthesis of taxol, showed cytotoxic activity against a variety of cancer cell lines in culture, and competitive interactions with the colchicine, podophyllotoxin, and vinblastine binding sites of tubulin were investigated.
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Optimum designs for estimating EDp based on raw optical density data
TL;DR: For raw optical density (ROD) data, such as those generated in biological assays employing an ELISA plate reader, ED p -optimal designs are identified for a family of homogeneous non-linear models with two parameters as discussed by the authors.
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Pseudoirroratin A, a new cytotoxic ent-kaurene diterpene from Isodon pseudo-irrorata.
Hongjie Zhang,Zhuting Fan,Ghee Teng Tan,Hee Byung Chai,John M. Pezzuto,Han-Dong Sun,Harry H. S. Fong +6 more
TL;DR: A new ent-kaurene diterpene, pseudoirroratin A (1), and a known diterPene, pseurata A, were isolated from Isodon pseudo-irrorata and the structure of 1 was elucidated by spectroscopic means including 1D and 2D NMR techniques.
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A Novel Cyclooxygenase-Inhibitory Stilbenolignan from the Seeds of Aiphanes aculeata.
Dongho Lee,Muriel Cuendet,Jose Schunke Vigo,James G. Graham,Fernando Cabieses,Harry H. S. Fong,John M. Pezzuto,A. Douglas Kinghorn +7 more
TL;DR: Aiphanol (1), a novel stilbenolignan, along with isorhapontigenin (2), piceatannol (3), and luteolin, were isolated by bioassay-guided fractionation from the seeds of Aiphanes aculeata as discussed by the authors.
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Synthesis, molecular docking and anticancer studies of peptides and iso-peptides.
Farukh Jabeen,Siva S. Panda,Tamara P. Kondratyuk,Eun-Jung Park,John M. Pezzuto,Ihsan-ul-Haq,C. Dennis Hall,Alan R. Katritzky +7 more
TL;DR: Chiral peptides and iso-peptides were synthesized in excellent yield by using benzotriazole mediated solution phase synthesis based on the hypothesis that epimerization should be suppressed in solution due to a faster coupling rate than SPPS.