John M. Pezzuto

TL;DR: Whether plants with ethnomedical uses from Vietnam and Laos have a higher hit rate in bioassay testing than plants collected from a national park in Vietnam with the goal of maximizing taxonomic diversity (“random” collection) is analyzed.

TL;DR: Bioassay‐guided fractionation of the antimalarial‐active CHCl3 extract of the dried stem of Nauclea orientalis has resulted in the isolation of two novel tetrahydro‐β‐carboline monoterpene alkaloid glucosides.

TL;DR: Methods are described for assessing the estrogenic or anti-estrogenic potential of test substances using cultured (human endometrial) Ishikawa cells, which possesses an estrogen-inducible alkaline phosphatase, and estrogenic activity is indicated by assessing by the rate of p-nitrophenol generated from p-Nitrophenylphosphate, subsequent to treatment with test compounds.

TL;DR: The antimelanoma activity of metabolites 2-5 was evaluated against two human melanoma cell lines, Mel-1 (lymph node) and Mel-2 (pleural fluid).

TL;DR: Six new 5,6-dihydro-alpha-pyrone derivatives (1-6), namely, brevipolides A-F, together with seven known compounds, including a 5,5,6,3'-trihydroxy-3,7,4'-trimethoxyflavone derivative (7), three flavonoids, a steroid glycoside, and two triterpenoids, were isolated from the entire plant of Hyptis bre