J
John M. Pezzuto
Researcher at Long Island University
Publications - 599
Citations - 38474
John M. Pezzuto is an academic researcher from Long Island University. The author has contributed to research in topics: Cancer & Resveratrol. The author has an hindex of 88, co-authored 588 publications receiving 35901 citations. Previous affiliations of John M. Pezzuto include Purdue University & Bandung Institute of Technology.
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Book ChapterDOI
Characterization of Natural Product Chemopreventive Agents
John M. Pezzuto,Jerome W. Kosmeder,Eun Jung Park,Sang Kook Lee,Muriel Cuendet,Joell J. Gills,Krishna P. Bhat,Simonida Grubjesic,Hye-Sung Park,Eugenia Mata-Greenwood,YingMeei Tan,Rong Yu,Daniel D. Lantvit,A. Douglas Kinghorn +13 more
TL;DR: Despite small decreases in overall cancer incidence and mortality rates in the US since the early 1990s, the total number of recorded cancer deaths continues to increase due to an aging and expanding population.
Journal ArticleDOI
Activity-guided isolation of steroidal alkaloid antiestrogen-binding site inhibitors from Pachysandra procumbens
Leng Chee Chang,Krishna P.L. Bhat,E. Pisha,Edward J. Kennelly,Harry H. S. Fong,John M. Pezzuto,A. D. Kinghorn +6 more
TL;DR: Four novel steroidal alkaloids were isolated from Pachysandra procumbens using a bioassay-guided fractionation based on inhibition of 3H-tamoxifen binding at the antiestrogen binding site (AEBS), and compounds 1-7 demonstrated significant activity as AEBS-inhibitory agents.
Journal ArticleDOI
Studies on di- and triterpenoids from Salvia staminea with cytotoxic activity
Gulacti Topcu,Esra N. Altiner,Seyda Gozcu,Belkıs Halfon,Zeynep Aydogmus,John M. Pezzuto,Bing-Nan Zhou,David G. I. Kingston +7 more
TL;DR: DNA damaging properties of the extracts and some isolated diterpenes were investigated against three yeasts and only taxodione gave a positive response and also showed the highest cytotoxic activity against a panel of cell lines among the investigated compounds in this study.
Journal ArticleDOI
Rourinoside and rouremin, antimalarial constituents from Rourea minor.
Zhen Dan He,Cui Ying Ma,Ghee Teng Tan,Kongmany Sydara,Pamela A. Tamez,Pamela A. Tamez,B. Southavong,Somsanith Bouamanivong,Djaja D. Soejarto,John M. Pezzuto,John M. Pezzuto,Harry H. S. Fong,Hongjie Zhang +12 more
TL;DR: Bioassay-directed fractionation of the antimalarial active CHCl(3) extract of the dried stems of Rourea minor (Gaertn.) Aubl.
Journal ArticleDOI
Inhibition of [3H]-LSD binding to 5-HT7 receptors by flavonoids from Scutellaria lateriflora.
Stefan Gafner,Chantal Bergeron,Laura L Batcha,Jesse Reich,John T. Arnason,Joanna E. Burdette,John M. Pezzuto,Cindy K. Angerhofer +7 more
TL;DR: From the results obtained in the testing of the pure compounds, it is evident that the activity on the 5-HT(7) receptor is at least partly due to the presence of flavonoids.