J
John M. Pezzuto
Researcher at Long Island University
Publications - 599
Citations - 38474
John M. Pezzuto is an academic researcher from Long Island University. The author has contributed to research in topics: Cancer & Resveratrol. The author has an hindex of 88, co-authored 588 publications receiving 35901 citations. Previous affiliations of John M. Pezzuto include Purdue University & Bandung Institute of Technology.
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Cardenolides from Nierembergia aristata.
TL;DR: The EtOAc extract of the whole plant of the Argentinian species Nierembergia aristata showed significant cytotoxicity against eleven different cancer cell lines, and bioassay-guided fractionation led to the isolation of three new cardenolides, the first report of the isolation from a species in the Solanaceae.
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Hedera nepalensis K. Koch: A Novel Source of Natural Cancer Chemopreventive and Anticancerous Compounds.
Laila Jafri,Samreen Saleem,Tamara P. Kondrytuk,Ihsan-ul Haq,Nazif Ullah,John M. Pezzuto,Bushra Mirza +6 more
TL;DR: The data have shown that H. nepalensis harbors cancer chemopreventive and cytotoxic agents, and HPLC‐DAD‐based quantification of lupeol in different plant tissues demonstrated that leaves of Hedera nepalensis are a rich source oflupeol.
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Suppression of nitric oxide synthase by thienodolin in lipopolysaccharide-stimulated RAW 264.7 murine macrophage cells.
Eun-Jung Park,John M. Pezzuto,Kyoung Hwa Jang,Sang Jip Nam,Sergio A. Bucarey,William Fenical +5 more
TL;DR: Thienodolin inhibited nitric oxide production in LPS-stimulated RAW 264.7 cells and blocked the degradation of IκBα resulting in inhibition of NF-κB p65 nuclear translocation, and inhibited the phosphorylation of signal transducers and activators of transcription 1 (STAT1) at Tyr701.
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Cell culture assay system for the evaluation of natural product-mediated anti-Hepatitis B virus activity
H. Mehdi,Ghee Teng Tan,John M. Pezzuto,Harry H. S. Fong,Norman R. Farnsworth,Farouk S. El-Feraly,M. A. Al-Yahya,Jaber S. Mossa,M.E. Peeples,M.R. Kernan,E.J. Rozhon +10 more
TL;DR: Using the hepatitis B virus -producing hepatoblastoma cell line, HepG2.2.15, which is stably transfected with the cloned HBV genome, methods were devised to examine the effects of test substances on intracellular extrachromosomal HBV DNA levels and secretion of hepatitis B surface antigen (HBsAg).
Journal Article
A correlative approach for the identification of antimutagens that demonstrate chemopreventive activity.
TL;DR: The combined use of these assays should aid in the discovery of antimutagenic agents that have cancer chemopreventive potential.