John M. Pezzuto

TL;DR: It is clear that flavonoids or flavonoid derivatives offer value for the chemoprevention of cancer, and greater emphasis has been placed on the study of methoxylated flavonoidal derivatives, which may demonstrate more favorable pharmacokinetic properties.

TL;DR: Data indicate that resveratrol diffuses rapidly across the intestinal epithelium, and extensive phase II metabolism during absorption might reduce resver atrol bioavailability.

TL;DR: Replacement of the stilbene ethylenic bridge of resveratrol with a 1,2,4-thiadiazole heterocycle and modification of the substituents on the two aromatic rings afforded potential chemopreventive agents with enhanced potencies and selectivities when evaluated as inhibitors of aromatase and NF-κB and inducers of quinone reductase 1 (QR1).

TL;DR: The eudesmane sesquiterpenoid, verticillatol (1), as well as the lignan, (+)-5′-demethoxyepiexcelsin (2), and a known Lignan (3), were isolated from Litsea verticillaata Hance, and the structures were elucidated by 1D and 2D NMR spectroscopy.

TL;DR: An extract obtained from a nonedible Peruvian legume was evaluated and found to be active as an inhibitor of cyclooxygenase, and the active component was identified as resveratrol, indicating potential to inhibit carcinogenesis at the stages of initiation, promotion, and progression.