J
John M. Pezzuto
Researcher at Long Island University
Publications - 599
Citations - 38474
John M. Pezzuto is an academic researcher from Long Island University. The author has contributed to research in topics: Cancer & Resveratrol. The author has an hindex of 88, co-authored 588 publications receiving 35901 citations. Previous affiliations of John M. Pezzuto include Purdue University & Bandung Institute of Technology.
Papers
More filters
Journal ArticleDOI
Mechanistic evaluation of new plant-derived compounds that inhibit HIV-1 reverse transcriptase.
Thitima Pengsuparp,L. Cai,Howard L. Constant,Harry H. S. Fong,Long-Ze Lin,A. D. Kinghorn,John M. Pezzuto,Geoffrey A. Cordell,K. Ingólfsdóttir,Hans-Ulrich Wagner +9 more
TL;DR: The mechanism of action of 1 beta-hydroxyaleuritolic acid 3-p-Hydroxybenzoate and protolichesterinic acid as HIV-1 RT inhibitors involves nonspecific binding to the enzyme at nonsubstrate binding sites, whereas swertifrancheside inhibits enzyme activity by binding toThe template-primer.
Patent
Pharmaceutical formulations of resveratrol and methods of use thereof
John M. Pezzuto,Richard C. Moon,Mei-Shiang Jang,Aomar Ouali,Shengzhao Lin,Barillas Karla Slowing +5 more
TL;DR: In this article, a method for preventing or treating skin conditions, disorders or diseases, such as maybe associated with or caused by inflammation, sun damage or natural aging, is provided.
Journal ArticleDOI
Biologic evaluation of curcumin and structural derivatives in cancer chemoprevention model systems
Stefan Gafner,Sang Kook Lee,Muriel Cuendet,Sophie Barthélémy,L. Vergnes,Serge Labidalle,Rajendra G. Mehta,Charles W. Boone,John M. Pezzuto +8 more
TL;DR: The data suggest that structural elements responsible for COX-1 and COx-2 inhibition do not correlate well with those responsible for inhibitingCOX-2 and iNOS gene expression, but elements capable of inhibiting COX/Nos gene expression also contribute to inhibition of TPA-induced ODC activity.
Journal ArticleDOI
Can ethnopharmacology contribute to the development of new anticancer drugs
TL;DR: A new strategy for the discovery of anticancer agents from plants is proposed in which ethnomedical information is correlated against pertinent published chemical and biological information, resulting in a prioritization of plants for collection.
Journal ArticleDOI
Antioxidant flavonoid glycosides from Daphniphyllum calycinum
E. J. C. Gamez,Lumonadio Luyengi,Sang Kook Lee,L.-F. Zhu,Bin Zhou,Harry H. S. Fong,John M. Pezzuto,A. D. Kinghorn +7 more
TL;DR: A novel flavonoid diglycoside and a previously known compound were isolated from an ethyl acetate extract of Daphniphyllum calycinum leaves that showed significant activity in a 1,1-diphenyl-2-picrylhydrazyl (DPPH) free-radical assay.