J
John M. Pezzuto
Researcher at Long Island University
Publications - 599
Citations - 38474
John M. Pezzuto is an academic researcher from Long Island University. The author has contributed to research in topics: Cancer & Resveratrol. The author has an hindex of 88, co-authored 588 publications receiving 35901 citations. Previous affiliations of John M. Pezzuto include Purdue University & Bandung Institute of Technology.
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Evaluation of selected indigenous medicinal plants from the western Himalayas for cytotoxicity and as potential cancer chemopreventive agents
Muhammad Asad Ghufran,Rizwana Aleem Qureshi,Aniqa Batool,Tamara P. Kondratyuk,Jacquelyn M. Guilford,Laura Marler,Leng Chee Chang,John M. Pezzuto +7 more
TL;DR: Positive responses observed in these bioassays illustrate the high potential of local medicinal plants and may be suggested that the plants under investigation contain potential chemopreventive compounds.
Journal ArticleDOI
Novel cytotoxic acylated oligorhamnosides from Mezzettia leptopoda.
Baoliang Cui,Heebyung Chai,T. Santisuk,Reutrakul,Norman R. Farnsworth,Geoffrey A. Cordell,John M. Pezzuto,A. D. Kinghorn +7 more
TL;DR: Activity-guided fractionation of a stem extract of Mezzettia leptopoda using human oral epidermoid carcinoma (KB) cells led to the isolation of seven highly acylated oligorhamnosides, four of which are novel and found to be weakly cytotoxic toward KB and/or human colon and lung cancer cell lines.
Journal ArticleDOI
Triterpenoids of the roots of Lavandula stoechas ssp. stoechas.
TL;DR: In this article, the triterpenes of Lavandula stoechas were determined by spectroscopic analyses and the chloroform extract and isolated compounds were evaluated for their growth inhibitory activity against several mammalian cell lines.
Journal Article
Characterization of tropane alkaloid aromatic esters that reverse the multidrug-resistance phenotype.
Qiuwen Mi,Baoliang Cui,Daniel Chávez,Heebyung Chai,Haiyuan Zhu,Geoffrey A. Cordell,Sam Hedayat,A. Douglas Kinghorn,John M. Pezzuto +8 more
TL;DR: Several new tropane alkaloid aromatic esters obtained by means of bioassay-directed fractionation were found to restore vinblastine sensitivity with cultured multidrug-resistant KB-VI cells, and inhibition was observed with IC50 values categorized as low, medium, and high.
Journal Article
Apoptotic anticancer effect of alvaradoin E isolated from Alvaradoa haitiensis.
Qiuwen Mi,Daniel D. Lantvit,Eulenia Reyes-Lim,Heebyung Chai,Sharnelle S. Phifer,Mansukh C. Wani,Monroe E. Wall,Ghee Teng Tan,Geoffrey A. Cordell,Norman R. Farnsworth,A. Douglas Kinghorn,John M. Pezzuto +11 more
TL;DR: Data suggest alvaradoin E is an effective anticancer agent that induces apoptosis, and additional studies to establish clinical utility should be of interest.