J
John M. Pezzuto
Researcher at Long Island University
Publications - 599
Citations - 38474
John M. Pezzuto is an academic researcher from Long Island University. The author has contributed to research in topics: Cancer & Resveratrol. The author has an hindex of 88, co-authored 588 publications receiving 35901 citations. Previous affiliations of John M. Pezzuto include Purdue University & Bandung Institute of Technology.
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Journal ArticleDOI
Constituents of the leaves and twigs of Ficus hispida.
Sergio R. Peraza-Sánchez,Heebyung Chai,Young G. Shin,Thawatchai Santisuk,Vichai Reutrakul,Norman R. Farnsworth,Geoffrey A. Cordell,John M. Pezzuto,A. Douglas Kinghorn +8 more
TL;DR: A new norisoprenoid, ficustriol, and the known phenanthroindolizidine alkaloid O-methyltylophorinidine, isolated from a CHCl3 extract of the leaves and twigs of Ficus hispida showed potent cytotoxic activity when tested against a small panel of human cancer cells.
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Screening Method for the Discovery of Potential Cancer Chemoprevention Agents Based on Mass Spectrometric Detection of Alkylated Keap1
Guowen Liu,Aimee L. Eggler,Birgit M. Dietz,Andrew D. Mesecar,Judy L. Bolton,John M. Pezzuto,Richard B. van Breemen +6 more
TL;DR: A high-throughput mass spectrometry-based screening assay was demonstrated to facilitate the discovery of chemoprevention agents in complex natural product mixtures.
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Cytotoxic Constituents of Baccharis gaudichaudiana
Fekadu Fullas,Raouf A. Hussain,Hee Byung Chai,John M. Pezzuto,Doel D. Soejarto,A. Douglas Kinghorn +5 more
TL;DR: Among the diterpenoids, gaudichaudol C [3], g audichaudone [4], and articulin acetate [5] exhibited significant cytotoxic activity against certain cancer cells.
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Macharistol, a new cytotoxic cinnamylphenol from the stems of Machaerium aristulatum.
Eun-Kyoung Seo,Nam Cheol Kim,Qiuwen Mi,Heebyung Chai,Monroe E. Wall,Mansukh C. Wani,Hernán A. Navarro,Jason P. Burgess,James G. Graham,Fernando Cabieses,Ghee Teng Tan,Norman R. Farnsworth,John M. Pezzuto,A. D. Kinghorn +13 more
TL;DR: A new cinnamylphenol, macharistol, along with a known pterocarpan, (+)-medicarpin, were isolated as cytotoxic constituents from the stems of Machaerium aristulatum and were found to be inactive at the highest dose tested.
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Induction of quinone reductase by withanolides.
Rosana I. Misico,Lynda L. Song,Adriana S. Veleiro,Adriana M. Cirigliano,Maria C. Tettamanzi,Gerardo Burton,Gloria M. Bonetto,Viviana E. Nicotra,Gloria L. Silva,Roberto R. Gil,Juan C. Oberti,A. Douglas Kinghorn,John M. Pezzuto +12 more
TL;DR: Thirty-seven naturally occurring withanolides were evaluated for their potential to induce quinone reductase with cultured murine hepatoma cells and Spiranoid and 18-functionalized withanolide were found to be potent inducers of the enzyme, while 5alpha-substituted derivatives exhibited weak activity.