John M. Pezzuto

TL;DR: Gedunin has significant in vitro activity but initially showed poor in vivo activity, and the results show the potential for both antimalarial drug and phytomedicine development from traditionally used plants.

TL;DR: A new cassane diterpene, dipteryxic acid, and a new isoflavonolignan, 5-methoxyxanthocercin A, as well as four known active compounds, isoliquiritigenin (3), 6,4'-dihydroxy-3'- methoxyaurone (4), sulfuretin (5), and (+/-)-balanophonin (6), are introduced.

TL;DR: A new quassinoid, yadanziolide S (1), was isolated from the seeds of the traditional Chinese medicinal herb, Brucea javanica, along with ten known compounds, which were evaluated for their potential to induce human promyelocytic leukemia (HL-60) cell differentiation, and to inhibit cyclooxygenase-1, -2, and 7,12-dimethylbenz[a]anthracene (DMBA)-induced lesions in a

TL;DR: Soulattrolide, a coumarin isolated from Calophyllum teysmannii latex, was found to be a potent inhibitor of HIV-1 reverse transcriptase (RT) with an IC50 of 0.34 microM.

TL;DR: Specific binding of ligands to RXR α was demonstrated through competitive binding using ultrafiltration LC−MS/MS (liquid chromatography−tandem mass spectrometry), and ligands could be ranked in order of affinity for RXRα.