K
Kwangsik Nho
Researcher at Indiana University – Purdue University Indianapolis
Publications - 7
Citations - 252
Kwangsik Nho is an academic researcher from Indiana University – Purdue University Indianapolis. The author has contributed to research in topics: Cognition & Apolipoprotein E. The author has an hindex of 4, co-authored 7 publications receiving 216 citations. Previous affiliations of Kwangsik Nho include University of Michigan & Regenstrief Institute.
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Journal ArticleDOI
Genome-wide association study of CSF biomarkers Aβ1-42, t-tau, and p-tau181p in the ADNI cohort
Sungeun Kim,Sungeun Kim,Shanker Swaminathan,Li Shen,Li Shen,Shannon L. Risacher,Kwangsik Nho,Kwangsik Nho,Tatiana Foroud,Tatiana Foroud,L. M. Shaw,John Q. Trojanowski,Steven G. Potkin,Matthew J. Huentelman,David Craig,Bryan M. DeChairo,Paul S. Aisen,Ronald C. Petersen,Michael W. Weiner,Michael W. Weiner,Andrew J. Saykin,Andrew J. Saykin +21 more
TL;DR: In addition to known candidate genes, APOE, TOMM40, and one hypothetical gene LOC100129500 partially overlapping APOE; one novel gene, EPC2, and several other interesting genes were associated with CSF biomarkers that are related to AD.
Journal ArticleDOI
Cortical surface biomarkers for predicting cognitive outcomes using group l2,1 norm
Jingwen Yan,Taiyong Li,Hua Wang,Heng Huang,Jing Wan,Jing Wan,Kwangsik Nho,Sungeun Kim,Shannon L. Risacher,Andrew J. Saykin,Li Shen,Li Shen +11 more
TL;DR: A new sparse multitask learning model called Group-Sparse Multi-task Regression and Feature Selection (G-SMuRFS) is proposed and demonstrates its effectiveness by examining the predictive power of detailed cortical thickness measures toward 3 types of cognitive scores in a large cohort.
Journal ArticleDOI
Comparing Variability, Severity, and Persistence of Depressive Symptoms as Predictors of Future Stroke Risk
Laura B. Zahodne,Paola Gilsanz,M. Maria Glymour,Laura E. Gibbons,Paul Brewster,Jamie Hamilton,Jesse Mez,Jessica R. Marden,Kwangsik Nho,Eric B. Larson,Paul K. Crane,Alden L. Gross +11 more
TL;DR: Capturing the dynamic nature of depression is relevant in assessing stroke risk, and fluctuating depressive symptoms may reflect a prodrome of reduced cerebrovascular integrity.
Journal ArticleDOI
Pattern Discovery in Brain Imaging Genetics via SCCA Modeling with a Generic Non-convex Penalty
Lei Du,Kefei Liu,Xiaohui Yao,Jingwen Yan,Shannon L. Risacher,Junwei Han,Lei Guo,Andrew J. Saykin,Li Shen,Michael W. Weiner,Paul S. Aisen,Ronald C. Petersen,Clifford R. Jack,William J. Jagust,John Q. Trojanowki,Arthur W. Toga,Laurel A. Beckett,Robert C. Green,John C. Morris,Leslie M. Shaw,Zaven S. Khachaturian,Greg Sorensen,Maria C. Carrillo,Lew Kuller,Marc Raichle,Steven M. Paul,Peter Davies,Howard Fillit,Franz Hefti,David M. Holtzman,M. Marcel Mesulam,William Z. Potter,Peter J. Snyder,Adam Schwartz,T. J. Montine,Ronald G. Thomas,Michael C. Donohue,Sarah Walter,Devon Gessert,Tamie Sather,Gus Jiminez,Archana B. Balasubramanian,Jennifer Mason,Iris Sim,Danielle J Harvey,Matt A. Bernstein,Nick C. Fox,Paul M. Thompson,Norbert Schuff,Charles DeCarli,Bret J. Borowski,Jeff Gunter,M. L. Senjem,Prashanthi Vemuri,David T.W. Jones,Kejal Kantarci,Chad Ward,Robert A. Koeppe,Norm Foster,Eric M. Reiman,Kewei Chen,Chet Mathis,Susan M. Landau,Nigel J. Cairns,Erin E. Franklin,Lisa Taylor-Reinwald,Virginia M.-Y. Lee,Magdalena Korecka,Michal J. Figurski,Karen Crawford,Scott C. Neu,Tatiana Foroud,Steven G. Potkin,Kelley Faber,Sungeun Kim,Kwangsik Nho,Leon J. Thal,Neil Buckholtz,Marilyn S. Albert,Richard Frank,John K. Hsiao,Jeffrey Kaye,Joseph F. Quinn,Lisa C. Silbert,Betty Lind,Raina Carter,Sara Dolen,Lon S. Schneider,Sonia Pawluczyk,Mauricio Beccera,Liberty Teodoro,Bryan M. Spann,James B. Brewer,Helen Vanderswag,Adam S. Fleisher,Judith L. Heidebrink,Joanne L. Lord,Sara S. Mason,Colleen S. Albers,David S. Knopman,Kris Johnson,Rachelle S. Doody,Javier Villanueva-Meyer,Valory N. Pavlik,Victoria Shibley,Munir Chowdhury,Susan Rountree,Mimi Dang,Yaakov Stern,Lawrence S. Honig,Karen L. Bell,Beau M. Ances,Maria Carroll,Mary L. Creech,Mark A. Mintun,Stacy Schneider,Angela Oliver,Daniel C. Marson,David S. Geldmacher,Marissa Natelson Love,Randall Griffith,David G. Clark,John C. Brockington,Erik D. Roberson,Hillel Grossman,Effie M. Mitsis,Raj C. Shah,Leyla deToledo-Morrell,Ranjan Duara,Maria T. Greig-Custo,Warren Barker,Chiadi U. Onyike,Daniel D'Agostino,Stephanie Kielb,Martin J. Sadowski,Mohammed O. Sheikh,Anaztasia Ulysse,Mrunalini Gaikwad,P. Murali Doraiswamy,Jeffrey R. Petrella,Salvador Borges-Neto,Terence Z. Wong,Edward Coleman,Steven E. Arnold,Jason Karlawish,David A. Wolk,Christopher M. Clark,Charles D. Smith,Greg Jicha,Peter A. Hardy,Partha Sinha,Elizabeth Oates,Gary R. Conrad,Oscar L. Lopez,Mary Ann Oakley,Donna M. Simpson,Anton P. Porsteinsson,Bonnie S. Goldstein,Kim Martin,Kelly M. Makino,M. Saleem Ismail,Connie Brand,Adrian Preda,Dana Nguyen,Kyle B. Womack,Dana Mathews,Mary Quiceno,Allan I. Levey,James J. Lah,Janet S. Cellar,Jeffrey M. Burns,Russell H. Swerdlow,William Brooks,Liana G. Apostolova,Kathleen Tingus,Ellen Woo,Daniel H.S. Silverman,Po H. Lu,George Bartzokis,Neill R. Graff-Radford,Francine Parfitt,Kim Poki-Walker,Martin R. Farlow,Ann Marie Hake,Brandy R. Matthews,Jared R. Brosch,Scott Herring,Christopher H. van Dyck,Richard E. Carson,Martha G. MacAvoy,Pradeep Varma,Howard Chertkow,Howard Bergman,Chris Hosein,Sandra E. Black,Bojana Stefanovic,Curtis Caldwell,Ging-Yuek Robin Hsiung,Benita Mudge,Vesna Sossi,Howard Feldman,Michele Assaly,Elizabeth Finger,Stephen Pasternack,Irina Rachisky,John A. Rogers,Dick Trost,Andrew Kertesz,Charles Bernick,Donna Munic,Emily Rogalski,Kristine Lipowski,Sandra Weintraub,Borna Bonakdarpour,Diana R. Kerwin,Chuang Kuo Wu,Nancy Johnson,Carl H. Sadowsky,Teresa Villena,Raymond Scott Turner,Kathleen Johnson,Brigid Reynolds,Reisa A. Sperling,Keith A. Johnson,Gad A. Marshall,Jerome A. Yesavage,Joy L. Taylor,Barton Lane,Allyson C. Rosen,Jared R. Tinklenberg,Marwan N. Sabbagh,Christine M. Belden,Sandra Jacobson,Sherye A. Sirrel,Neil W. Kowall,Ronald J. Killiany,Andrew E. Budson,Alexander Norbash,Patricia Lynn Johnson,Thomas O. Obisesan,Saba Wolday,Joanne S. Allard,Alan J. Lerner,Paula Ogrocki,Curtis Tatsuoka,Parianne Fatica,Evan Fletcher,Pauline Maillard,John M Olichney,Owen Carmichael,Smita Kittur,Michael Borrie,T. Y. Lee,Rob Bartha,Sterling C. Johnson,Sanjay Asthana,Cynthia M. Carlsson,Pierre N. Tariot,Anna Burke,Ann Marie Milliken,Nadira Trncic,Stephanie Reeder,Vernice Bates,Horacio Capote,Michelle Rainka,Douglas W. Scharre,Maria Kataki,Brendan J Kelly,Earl A. Zimmerman,Dzintra Celmins,Alice D. Brown,Godfrey D. Pearlson,Karen Blank,Karen E. Anderson,Laura A. Flashman,Marc Seltzer,Mary L. Hynes,Robert B. Santulli,Kaycee M. Sink,Leslie Gordineer,Jeff D. Williamson,Pradeep Garg,Franklin Watkins,Brian R. Ott,Geoffrey Tremont,Lori A. Daiello,Stephen Salloway,Paul Malloy,Stephen Correia,Howard J. Rosen,Bruce L. Miller,David C. Perry,Jacobo Mintzer,Kenneth M. Spicer,David Bachman,Nunzio Pomara,Raymundo Hernando,Antero Sarrael,Susan K. Schultz,Karen Ekstam Smith,Hristina Koleva,Ki Won Nam,Hyungsub Shim,Norman R. Relkin,Gloria Chaing,Michael Lin,Lisa D. Ravdin,Amanda Smith,Balebail Ashok Raj,Kristin Fargher +309 more
TL;DR: A unified non- Convex SCCA model, based on seven non-convex functions, for unbiased estimation and stable feature selection simultaneously is designed and an efficient optimization algorithm is proposed, which obtains both higher correlation coefficients and better canonical loading patterns.
Journal ArticleDOI
APOE, TOMM40, and sex interactions on neural network connectivity.
Tianqi Li,Colleen Pappas,Scott T. Le,Qian Wang,Brandon S. Klinedinst,Brittany Larsen,Amy Pollpeter,Ling Yi Lee,Michael W. Lutz,William K. Gottschalk,Russell H. Swerdlow,Kwangsik Nho,Auriel A. Willette +12 more
TL;DR: In this article, the authors examined 21 orthogonal neural networks among 8,222 middle-aged to aged participants in the UK Biobank cohort and found that APOE e4 was associated with less strength in multiple networks, while '650 G versus A carriage was related to more language comprehension network strength.