M
Marja-Liisa Nuotio
Researcher at National Institutes of Health
Publications - 18
Citations - 2276
Marja-Liisa Nuotio is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Genome-wide association study & Metabolic syndrome. The author has an hindex of 13, co-authored 17 publications receiving 1897 citations. Previous affiliations of Marja-Liisa Nuotio include University of Helsinki & National Institute for Health and Welfare.
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Journal ArticleDOI
GWAS of 126,559 Individuals Identifies Genetic Variants Associated with Educational Attainment
Cornelius A. Rietveld,Sarah E. Medland,Jaime Derringer,Jian Yang,Tõnu Esko,Nicolas W. Martin,Nicolas W. Martin,Harm-Jan Westra,Konstantin Shakhbazov,Abdel Abdellaoui,Arpana Agrawal,Eva Albrecht,Behrooz Z. Alizadeh,Najaf Amin,John Barnard,Sebastian E. Baumeister,Kelly S. Benke,Lawrence F. Bielak,Jeffrey A. Boatman,Patricia A. Boyle,Gail Davies,Christiaan de Leeuw,Niina Eklund,Niina Eklund,Daniel S. Evans,Rudolf Ferhmann,Krista Fischer,Christian Gieger,Håkon K. Gjessing,Sara Hägg,Sara Hägg,Jennifer R. Harris,Caroline Hayward,Christina Holzapfel,Carla A. Ibrahim-Verbaas,Erik Ingelsson,Erik Ingelsson,Bo Jacobsson,Bo Jacobsson,Peter K. Joshi,Astanand Jugessur,Marika Kaakinen,Stavroula Kanoni,Juha Karjalainen,Ivana Kolcic,Kati Kristiansson,Kati Kristiansson,Zoltán Kutalik,Zoltán Kutalik,Jari Lahti,Sang Hong Lee,Peng Lin,Penelope A. Lind,Yongmei Liu,Kurt Lohman,Marisa Loitfelder,George McMahon,Pedro Marques Vidal,Osorio Meirelles,Lili Milani,Ronny Myhre,Marja-Liisa Nuotio,Marja-Liisa Nuotio,Christopher Oldmeadow,Katja Petrovic,Wouter J. Peyrot,Ozren Polasek,Lydia Quaye,Eva Reinmaa,John P. Rice,Thais S. Rizzi,Helena Schmidt,Reinhold Schmidt,Albert V. Smith,Jennifer A. Smith,Toshiko Tanaka,Antonio Terracciano,Antonio Terracciano,Matthijs J. H. M. van der Loos,Veronique Vitart,Henry Völzke,Jürgen Wellmann,Lei Yu,Wei Zhao,Jüri Allik,John Attia,Stefania Bandinelli,François Bastardot,Jonathan P. Beauchamp,David A. Bennett,Klaus Berger,Laura J. Bierut,Dorret I. Boomsma,Ute Bültmann,Harry Campbell,Christopher F. Chabris,Lynn Cherkas,Mina K. Chung,Francesco Cucca,Francesco Cucca,Mariza de Andrade,Philip L. De Jager,Jan-Emmanuel De Neve,Jan-Emmanuel De Neve,Ian J. Deary,George Dedoussis,Panos Deloukas,Maria Dimitriou,Guoný Eiríksdóttir,Martin F. Elderson,Johan G. Eriksson,David M. Evans,Jessica D. Faul,Luigi Ferrucci,Melissa E. Garcia,Henrik Grönberg,Vilmundur Guonason,Per Hall,Juliette Harris,Tamara B. Harris,Nicholas D. Hastie,Andrew C. Heath,Dena G. Hernandez,Wolfgang Hoffmann,Adriaan Hofman,Rolf Holle,Elizabeth G. Holliday,Jouke-Jan Hottenga,William G. Iacono,Thomas Illig,Marjo-Riitta Järvelin,Marjo-Riitta Järvelin,Marjo-Riitta Järvelin,Mika Kähönen,Jaakko Kaprio,Jaakko Kaprio,Robert M. Kirkpatrick,Matthew Kowgier,Antti Latvala,Antti Latvala,Lenore J. Launer,Debbie A Lawlor,Terho Lehtimäki,Jingmei Li,Paul Lichtenstein,Peter Lichtner,David C. Liewald,Pamela A. F. Madden,Patrik K. E. Magnusson,Tomi E. Mäkinen,Marco Masala,Matt McGue,Andres Metspalu,Andreas Mielck,Michael B. Miller,Grant W. Montgomery,Sutapa Mukherjee,Sutapa Mukherjee,Dale R. Nyholt,Ben A. Oostra,Lyle J. Palmer,Aarno Palotie,Aarno Palotie,Brenda W.J.H. Penninx,Markus Perola,Markus Perola,Markus Perola,Patricia A. Peyser,Martin Preisig,Katri Räikkönen,Olli T. Raitakari,Anu Realo,Susan M. Ring,Samuli Ripatti,Samuli Ripatti,Samuli Ripatti,Fernando Rivadeneira,Igor Rudan,Aldo Rustichini,Veikko Salomaa,Antti-Pekka Sarin,David Schlessinger,Rodney J. Scott,Harold Snieder,Beate St Pourcain,John M. Starr,Jae Hoon Sul,Ida Surakka,Ida Surakka,Rauli Svento,Alexander Teumer,Henning Tiemeier,Frank J. A. van Rooij,David R. Van Wagoner,Erkki Vartiainen,Jorma Viikari,Peter Vollenweider,Judith M. Vonk,Gérard Waeber,David R. Weir,H.-Erich Wichmann,Elisabeth Widen,Gonneke Willemsen,James F. Wilson,Alan F. Wright,Dalton Conley,George Davey-Smith,Lude Franke,Patrick J. F. Groenen,Albert Hofman,Magnus Johannesson,Sharon L.R. Kardia,Robert F. Krueger,David Laibson,Nicholas G. Martin,Michelle N. Meyer,Michelle N. Meyer,Danielle Posthuma,Danielle Posthuma,Roy Thurik,Nicholas J. Timpson,André G. Uitterlinden,Cornelia M. van Duijn,Cornelia M. van Duijn,Peter M. Visscher,Peter M. Visscher,Daniel J. Benjamin,David Cesarini,David Cesarini,David Cesarini,Philipp Koellinger +230 more
TL;DR: In this article, a genome-wide association study of educational attainment was conducted in a discovery sample of 101,069 individuals and a replication sample of 25,490 individuals, and three independent SNPs are genome wide significant (rs9320913, rs11584700, rs4851266).
Journal ArticleDOI
The prevalence of metabolic syndrome and metabolically healthy obesity in Europe: a collaborative analysis of ten large cohort studies.
Jana V. van Vliet-Ostaptchouk,Marja-Liisa Nuotio,Marja-Liisa Nuotio,Sandra N. Slagter,Dany Doiron,Krista Fischer,Luisa Foco,Amadou Gaye,Martin Gögele,Margit Heier,Tero Hiekkalinna,Tero Hiekkalinna,Anni Joensuu,Anni Joensuu,Christopher Newby,Chao Pang,Eemil Partinen,Eva Reischl,Christine Schwienbacher,Mari-Liis Tammesoo,Morris A. Swertz,Paul Burton,Vincent Ferretti,Isabel Fortier,Lisette Giepmans,Jennifer R. Harris,Hans L. Hillege,Jostein Holmen,Antti Jula,Jenny E. Kootstra-Ros,Kirsti Kvaløy,Turid Lingaas Holmen,Satu Männistö,Andres Metspalu,Kristian Midthjell,Madeleine J Murtagh,Annette Peters,Peter P. Pramstaller,Timo Saaristo,Veikko Salomaa,Ronald P. Stolk,Matti Uusitupa,Pim van der Harst,Melanie M. van der Klauw,Melanie Waldenberger,Markus Perola,Markus Perola,Markus Perola,Bruce H. R. Wolffenbuttel +48 more
TL;DR: There is considerable variability in the prevalence of healthy obesity across the different European populations studied, even when unified criteria were used to classify this phenotype.
Journal ArticleDOI
The Role of Adiposity in Cardiometabolic Traits: A Mendelian Randomization Analysis
Tove Fall,Sara Hägg,Sara Hägg,Reedik Mägi,Reedik Mägi,Alexander Ploner,Krista Fischer,Momoko Horikoshi,Momoko Horikoshi,Antti-Pekka Sarin,Gudmar Thorleifsson,Claes Ladenvall,Mart Kals,Maris Kuningas,Harmen H.M. Draisma,Janina S. Ried,Natalie R. van Zuydam,Ville Huikari,Massimo Mangino,Emily Sonestedt,Beben Benyamin,Beben Benyamin,Christopher P. Nelson,Christopher P. Nelson,Natalia V. Rivera,Kati Kristiansson,Huei-Yi Shen,Huei-Yi Shen,Aki S. Havulinna,Abbas Dehghan,Louise A. Donnelly,Marika Kaakinen,Marja-Liisa Nuotio,Neil Robertson,Neil Robertson,Renée F.A.G. de Bruijn,M. Arfan Ikram,Najaf Amin,Anthony J. Balmforth,Peter S. Braund,Alex S. F. Doney,Angela Döring,Paul Elliott,Tõnu Esko,Oscar H. Franco,Solveig Gretarsdottir,Anna-Liisa Hartikainen,Kauko Heikkilä,Karl-Heinz Herzig,Hilma Holm,Jouke-Jan Hottenga,Elina Hyppönen,Thomas Illig,Aaron Isaacs,Bo Isomaa,Lennart C. Karssen,Johannes Kettunen,Johannes Kettunen,Wolfgang Koenig,Kari Kuulasmaa,Tiina Laatikainen,Jaana Laitinen,Cecilia M. Lindgren,Valeriya Lyssenko,Valeriya Lyssenko,Esa Läärä,Nigel W. Rayner,Nigel W. Rayner,Nigel W. Rayner,Satu Männistö,Anneli Pouta,Anneli Pouta,Wolfgang Rathmann,Fernando Rivadeneira,Aimo Ruokonen,Markku J. Savolainen,Eric J.G. Sijbrands,Kerrin S. Small,Jan Smit,Valgerdur Steinthorsdottir,Ann-Christine Syvänen,Anja Taanila,Martin D. Tobin,André G. Uitterlinden,Sara M. Willems,Gonneke Willemsen,Jacqueline C.M. Witteman,Markus Perola,Markus Perola,Alun Evans,Jean Ferrières,Jarmo Virtamo,Frank Kee,David-Alexandre Trégouët,Dominique Arveiler,Philippe Amouyel,Marco M Ferrario,Paolo Brambilla,Alistair S. Hall,Andrew C. Heath,Pamela A. F. Madden,Nicholas G. Martin,Grant W. Montgomery,John Whitfield,Antti Jula,Paul Knekt,Ben A. Oostra,Cornelia M. van Duijn,Brenda W.J.H. Penninx,George Davey Smith,Jaakko Kaprio,Jaakko Kaprio,Nilesh J. Samani,Nilesh J. Samani,Christian Gieger,Annette Peters,H.-Erich Wichmann,Dorret I. Boomsma,Eco J. C. de Geus,Tiinamaija Tuomi,Chris Power,Christopher J Hammond,Tim D. Spector,Lars Lind,Marju Orho-Melander,Colin N. A. Palmer,Andrew D. Morris,Leif Groop,Leif Groop,Marjo-Riitta Järvelin,Veikko Salomaa,Erkki Vartiainen,Albert Hofman,Samuli Ripatti,Samuli Ripatti,Samuli Ripatti,Andres Metspalu,Unnur Thorsteinsdottir,Unnur Thorsteinsdottir,Kari Stefansson,Kari Stefansson,Nancy L. Pedersen,Mark I. McCarthy,Mark I. McCarthy,Mark I. McCarthy,Erik Ingelsson,Erik Ingelsson,Erik Ingelsson,Inga Prokopenko,Inga Prokopenko,Inga Prokopenko +150 more
TL;DR: In this study, Prokopenko and colleagues provide novel evidence for causal relationship between adiposity and heart failure and increased liver enzymes using a Mendelian randomization study design.
Journal ArticleDOI
DataSHIELD: taking the analysis to the data, not the data to the analysis
Amadou Gaye,Yannick Marcon,Julia Isaeva,Philippe Laflamme,Andrew Turner,Elinor Jones,Joel T. Minion,Andy Boyd,Chris Newby,Marja-Liisa Nuotio,Marja-Liisa Nuotio,Rebecca Wilson,Oliver Butters,Barnaby Murtagh,Barnaby Murtagh,Ipek Demir,Dany Doiron,Lisette Giepmans,Susan E. Wallace,Isabelle Budin-Ljøsne,Carsten Oliver Schmidt,Paolo Boffetta,Mathieu Boniol,Maria Bota,Kim W. Carter,N. Deklerk,Chris Dibben,Richard W. Francis,Tero Hiekkalinna,Tero Hiekkalinna,Kristian Hveem,Kirsti Kvaløy,Seán R. Millar,Ivan J. Perry,Annette Peters,Catherine M. Phillips,Frank Popham,Gillian M. Raab,Eva Reischl,Nuala A. Sheehan,Melanie Waldenberger,Markus Perola,Edwin R. van den Heuvel,John Macleod,Bartha Maria Knoppers,Ronald P. Stolk,Isabel Fortier,Jennifer R. Harris,Bruce H R Woffenbuttel,Madeleine J Murtagh,Vincent Ferretti,Paul Burton,Paul Burton +52 more
TL;DR: The technical implementation of DataSHIELD is described, using a modified R statistical environment linked to an Opal database deployed behind the computer firewall of each DC, which is currently used by the Healthy Obese Project and the Environmental Core Project for the federated analysis of 10 data sets across eight European countries.
Journal ArticleDOI
Adiposity as a cause of cardiovascular disease: a Mendelian randomization study
Sara Hägg,Sara Hägg,Sara Hägg,Tove Fall,Tove Fall,Tove Fall,Alexander Ploner,Reedik Mägi,Krista Fischer,Harmen H.M. Draisma,Mart Kals,Paul S. de Vries,Abbas Dehghan,Sara M. Willems,Antti-Pekka Sarin,Antti-Pekka Sarin,Kati Kristiansson,Marja-Liisa Nuotio,Aki S. Havulinna,Renée F A G de Bruijn,M. Arfan Ikram,Maris Kuningas,Bruno H. Stricker,Oscar H. Franco,Beben Benyamin,Christian Gieger,Alistair S. Hall,Ville Huikari,Antti Jula,Marjo-Riitta Järvelin,Marika Kaakinen,Jaakko Kaprio,Michael Kobl,Massimo Mangino,Christopher P. Nelson,Aarno Palotie,Nilesh J. Samani,Tim D. Spector,David P. Strachan,Martin D. Tobin,John Whitfield,André G. Uitterlinden,Veikko Salomaa,Ann-Christine Syvänen,Ann-Christine Syvänen,Kari Kuulasmaa,Patrik K. E. Magnusson,Tõnu Esko,Albert Hofman,Eco J. C. de Geus,Lars Lind,Vilmantas Giedraitis,Markus Perola,Alun Evans,Jean Ferrières,Jarmo Virtamo,Frank Kee,David-Alexandre Trégouët,Dominique Arveiler,Philippe Amouyel,Francesco Gianfagna,Paolo Brambilla,Samuli Ripatti,Cornelia M. van Duijn,Andres Metspalu,Inga Prokopenko,Mark I. McCarthy,Nancy L. Pedersen,Erik Ingelsson +68 more
TL;DR: In this paper, the effect of body mass index (BMI) on risk of cardiovascular diseases was investigated using Mendelian randomization (MR) methods, and the results indicated a strong association between BMI and incident coronary heart disease (CHD), heart failure, and ischaemic stroke.