Mark M. Davis

TL;DR: Tetramers of human lymphocyte antigen A2 that were complexed with two different human immunodeficiency virus (HIV)-derived peptides or with a peptide derived from influenza A matrix protein bound to peptide-specific cytotoxic T cells in vitro and to T cells from the blood of HIV-infected individuals and correlated well with cytotoxicity assays.

TL;DR: Immunological synapse formation is now shown to be an active and dynamic mechanism that allows T cells to distinguish potential antigenic ligands and was a determinative event for T cell proliferation.

TL;DR: This view of T-cell recognition has implications for how the receptors might be selected in the thymus and how they (and immunoglobulins) may have arisen during evolution.

TL;DR: Of 10 distinct cloned DNA copies of mRNAs expressed in T lymphocytes but not in B lymphocytes and associated with membrane-bound polysomes, one hybridizes to a region of the genome that has rearranged in a T- cell lymphoma and several T-cell hybridomas, suggesting that it encodes one chain of the elusive antigen receptor on the surface of T lymphocyte.

TL;DR: It is shown that increasing miR-181a expression in mature T cells augments the sensitivity to peptide antigens, while inhibition in the immature T cells reduces sensitivity and impairs both positive and negative selection.