R
Ralph B. D'Agostino
Researcher at Wake Forest University
Publications - 1336
Citations - 250792
Ralph B. D'Agostino is an academic researcher from Wake Forest University. The author has contributed to research in topics: Framingham Heart Study & Framingham Risk Score. The author has an hindex of 226, co-authored 1287 publications receiving 229636 citations. Previous affiliations of Ralph B. D'Agostino include VA Boston Healthcare System & University of Illinois at Urbana–Champaign.
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Journal ArticleDOI
Essentials of Biostatistics.
Journal ArticleDOI
A genome-wide search for genes affecting circulating fibrinogen levels in the Framingham Heart Study
Qiong Yang,Geoffrey H. Tofler,L. Adrienne Cupples,Martin G. Larson,DaLi Feng,Klaus Lindpaintner,Klaus Lindpaintner,Daniel Levy,Ralph B. D'Agostino,Christopher J. O'Donnell +9 more
TL;DR: The results suggest that there may be influential genetic regions on these chromosomes on 4q28, and while no linkage with genome-wide significance was detected, further research to confirm the findings is warranted.
Journal ArticleDOI
Prostate-specific membrane antigen-targeted liposomes specifically deliver the Zn(2+) chelator TPEN inducing oxidative stress in prostate cancer cells.
Christopher H. Stuart,Ravi Singh,Thomas L. Smith,Ralph B. D'Agostino,David L. Caudell,K.C. Balaji,William H. Gmeiner +6 more
TL;DR: In vivo experiments show that TPEN-loaded, aptamer-targeted liposomes reduce tumor growth in a human prostate cancer xenograft model and delivery of TPEN using aptamer to target prostate cancer cells overexpression prostate-specific membrane antigen results in specific delivery to targeted cells.
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A Novel R848-Conjugated Inactivated Influenza Virus Vaccine Is Efficacious and Safe in a Neonate Nonhuman Primate Model.
Beth C. Holbrook,Jong R. Kim,Lance K. Blevins,Matthew J. Jorgensen,Nancy D. Kock,Ralph B. D'Agostino,S. Tyler Aycock,Mallinath B. Hadimani,S. Bruce King,Griffith D. Parks,Martha A. Alexander-Miller +10 more
TL;DR: Results show that this vaccine induces high-level virus-specific Ab- and cell-mediated responses in neonates that result in increased virus clearance and reduced lung pathology postchallenge compared with the nonadjuvanted virus vaccine, and support further exploration of this new conjugate influenza vaccine approach as a platform for use in the at-risk neonate population.
Journal ArticleDOI
Association of parental obesity with concentrations of select systemic biomarkers in nonobese offspring: the Framingham Heart Study.
Wolfgang Lieb,Michael J. Pencina,Michael J. Pencina,Katherine J. Lanier,Geoffrey H. Tofler,Daniel Levy,Caroline S. Fox,Caroline S. Fox,Thomas J. Wang,Thomas J. Wang,Ralph B. D'Agostino,Ramachandran S. Vasan,Ramachandran S. Vasan +12 more
TL;DR: It is suggested that offspring with a high risk of developing obesity have an altered biomarker profile, characterized by systemic inflammation and increased neurohormonal activity, even in the absence of obesity, consistent with the notion that parental obesity may confer an increased susceptibility to other adiposity-associated traits.