R
Ralph B. D'Agostino
Researcher at Wake Forest University
Publications - 1336
Citations - 250792
Ralph B. D'Agostino is an academic researcher from Wake Forest University. The author has contributed to research in topics: Framingham Heart Study & Framingham Risk Score. The author has an hindex of 226, co-authored 1287 publications receiving 229636 citations. Previous affiliations of Ralph B. D'Agostino include VA Boston Healthcare System & University of Illinois at Urbana–Champaign.
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Journal ArticleDOI
QT interval is a heritable quantitative trait with evidence of linkage to chromosome 3 in a genome-wide linkage analysis: The Framingham Heart Study
Christopher Newton-Cheh,Martin G. Larson,Diane Corey,Emelia J. Benjamin,Alan Herbert,Daniel Levy,Daniel Levy,Ralph B. D'Agostino,Christopher J. O'Donnell,Christopher J. O'Donnell +9 more
TL;DR: QT and related ECG intervals are heritable traits in a large unselected population and suggestive evidence for a quantitative trait locus on chromosome 3 influencing QT interval duration is provided.
Journal ArticleDOI
Association of multiple inflammatory markers with carotid intimal medial thickness and stenosis (from the Framingham Heart Study).
Avni H. Thakore,Chao-Yu Guo,Martin G. Larson,Diane Corey,Thomas J. Wang,Ramachandran S. Vasan,Ralph B. D'Agostino,Izabella Lipinska,John F. Keaney,Emelia J. Benjamin,Christopher J. O'Donnell,Christopher J. O'Donnell +11 more
TL;DR: There were modest associations of inflammatory markers, particularly IL-6, with carotid atherosclerosis, and this association appears more pronounced in current smokers than in former smokers and nonsmokers.
Journal ArticleDOI
A Meta-analysis of Four Genome-Wide Association Studies of Survival to Age 90 Years or Older: The Cohorts for Heart and Aging Research in Genomic Epidemiology Consortium
Anne B. Newman,Stefan Walter,Kathryn L. Lunetta,Kathryn L. Lunetta,Melissa E. Garcia,P. Eline Slagboom,Kaare Christensen,Alice M. Arnold,Thor Aspelund,Yurii S. Aulchenko,Emelia J. Benjamin,Emelia J. Benjamin,Lene Christiansen,Ralph B. D'Agostino,Ralph B. D'Agostino,Annette L. Fitzpatrick,Nora Franceschini,Nicole L. Glazer,Vilmundur Gudnason,Albert Hofman,Robert C. Kaplan,David Karasik,David Karasik,Margaret Kelly-Hayes,Margaret Kelly-Hayes,Douglas P. Kiel,Douglas P. Kiel,Lenore J. Launer,Kristin D. Marciante,Joseph M. Massaro,Joseph M. Massaro,Iva Miljkovic,Mike A. Nalls,Dena G. Hernandez,Bruce M. Psaty,Bruce M. Psaty,Fernando Rivadeneira,Jerome I. Rotter,Sudha Seshadri,Albert V. Smith,Kent D. Taylor,Henning Tiemeier,Hae-Won Uh,André G. Uitterlinden,James W. Vaupel,Jeremy D. Walston,Rudi G. J. Westendorp,Tamara B. Harris,Thomas Lumley,Cornelia M. van Duijn,Joanne M. Murabito,Joanne M. Murabito +51 more
TL;DR: A meta-analysis of genome-wide association studies in Caucasians from four prospective cohort studies found that survival studies of larger size or more extreme or specific phenotypes may support or refine these initial findings.
Journal ArticleDOI
Guideline-Based Statin Eligibility, Coronary Artery Calcification, and Cardiovascular Events
Amit Pursnani,Amit Pursnani,Joseph M. Massaro,Joseph M. Massaro,Ralph B. D'Agostino,Ralph B. D'Agostino,Christopher J. O'Donnell,Christopher J. O'Donnell,Udo Hoffmann +8 more
TL;DR: In this community-based primary prevention cohort, the ACC/AHA guidelines for determining statin eligibility, compared with the ATP III, were associated with greater accuracy and efficiency in identifying increased risk of incident CVD and subclinical coronary artery disease, particularly in intermediate-risk participants.
Journal ArticleDOI
Metabolic Control and Prevalent Cardiovascular Disease in Non-Insulin-dependent Diabetes Mellitus (NIDDM): The NIDDM Patient Outcomes Research Team
James B. Meigs,Daniel E. Singer,Lisa M. Sullivan,Kimberly A. Dukes,Ralph B. D'Agostino,David M. Nathan,Edward H. Wagner,Sherrie H. Kaplan,Sheldon Greenfield +8 more
TL;DR: Glycemic control is not associated with prevalent cardiovascular disease in this large population of individuals with NIDDM, and conventional cardiovascular disease risk factors are independently associated with cardiovascular disease and be a more promising focus for clinical intervention to reduce atherosclerotic complications in NID DM.