R
Ralph B. D'Agostino
Researcher at Wake Forest University
Publications - 1336
Citations - 250792
Ralph B. D'Agostino is an academic researcher from Wake Forest University. The author has contributed to research in topics: Framingham Heart Study & Framingham Risk Score. The author has an hindex of 226, co-authored 1287 publications receiving 229636 citations. Previous affiliations of Ralph B. D'Agostino include VA Boston Healthcare System & University of Illinois at Urbana–Champaign.
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Journal ArticleDOI
Traditional multiplicity adjustment methods in clinical trials
TL;DR: This tutorial discusses important statistical problems arising in clinical trials with multiple clinical objectives based on different clinical variables, evaluation of several doses or regiments of a new treatment, analysis of multiple patient subgroups, etc.
Lipid-Related Markers and Cardiovascular Disease Prediction
Emanuele Di Angelantonio,Pei Gao,Lisa Pennells,Stephen Kaptoge,Muriel J. Caslake,Alexander J. Thompson,Adam S. Butterworth,Nadeem Sarwar,David Wormser,Danish Saleheen,Christie M. Ballantyne,Bruce M. Psaty,Johan Sundström,Paul M. Ridker,Dorothea Nagel,Richard F. Gillum,Ian Ford,Pierre Ducimetière,Stefan Kiechl,Robin P. F. Dullaart,Gerd Assmann,Ralph B. D'Agostino,Gilles R. Dagenais,Jackie A. Cooper,Daan Kromhout,Altan Onat,Robert W. Tipping,Agustin Gomez-de-la-Camara,Annika Rosengren,Susan E. Sutherland,John Gallacher,F. Gerry R. Fowkes,Edoardo Casiglia,Albert Hofman,Veikko Salomaa,Elizabeth Barrett-Connor,Robert Clarke,Eric J. Brunner,J. Wouter Jukema,Leon A. Simons,Manjinder S. Sandhu,Nicholas J. Wareham,Kay-Tee Khaw,Jussi Kauhanen,Jukka T. Salonen,William J. Howard,Børge G. Nordestgaard,Angela M. Wood,Simon G. Thompson,S. Matthijs Boekholdt,Naveed Sattar,Chris J. Packard,Vilmundur Gudnason,John Danesh +53 more
TL;DR: In this article, the authors evaluated the value of assessing various emerging lipid-related markers for prediction of first cardiovascular events, and concluded that the addition of information on various lipidrelated markers to total cholesterol, HDL-C, and other conventional risk factors yielded improvement in the model's discrimination.
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A longitudinal study of body mass index and lens opacities: The Framingham studies
Rita Hiller,Marvin J. Podgor,Robert D. Sperduto,Leila Nowroozi,Peter W.F. Wilson,Ralph B. D'Agostino,Theodore Colton +6 more
TL;DR: It is suggested that BMI, a potentially modifiable characteristic, is associated with the development of cortical and posterior subcapsular lens opacities.
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Comments on ‘Integrated discrimination and net reclassification improvements—Practical advice’
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Efficacy endpoint selection and multiplicity adjustment methods in clinical trials with inherent multiple endpoint issues.
TL;DR: Examining some practical clinical decision‐making scenarios for the selection and analysis of efficacy outcome measures in clinical trials with inherent multiplicity components finds that some are more difficult than others.