Stephan Ripke

TL;DR: The phenotypic associations between major depression and cardio-metabolic traits may partly reflect their overlapping genetic aetiology irrespective of the age depression first presents.

TL;DR: The analysis of ROH suggested that there was significant heterogeneity of effect across studies in effect, and it was associated with genotyping platform and country of origin, and the results of the ROH analysis show that differences across studies can lead to conflicting systematic genome‐wide differences between cases and controls that are unaccounted for by traditional covariates.

TL;DR: This work calls this concept the Universal Control Repository Network (UNICORN), a means to perform association analyses without necessitating direct access to individual-level control data, and demonstrates how it controls false positives, provides power similar to that achieved when all control data are directly accessible, and enhances power when controlData are limiting or even imperfectly matched ancestrally.

TL;DR: Studying patterns of assortative mating and anticipation, it appears increased polygenic risk is contributed by affected individuals who married into the family, resulting in an increasing genetic risk over generations, which may explain the observation of anticipation in mood disorders.

TL;DR: Genetic variation in the lymphotoxin-α cascade (LTA, LGALS2, and PSMA6) is not a major risk factor for ischemic stroke, and none of these associations could be replicated in the UK population.