S
Stephan Ripke
Researcher at Broad Institute
Publications - 311
Citations - 80990
Stephan Ripke is an academic researcher from Broad Institute. The author has contributed to research in topics: Genome-wide association study & Population. The author has an hindex of 97, co-authored 278 publications receiving 63650 citations. Previous affiliations of Stephan Ripke include Icahn School of Medicine at Mount Sinai & University of Texas Southwestern Medical Center.
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Journal ArticleDOI
Improving genetic prediction by leveraging genetic correlations among human diseases and traits
Robert Maier,Zhihong Zhu,Sang Hong Lee,Sang Hong Lee,Maciej Trzaskowski,Douglas M. Ruderfer,Eli A. Stahl,Stephan Ripke,Naomi R. Wray,Jian Yang,Peter M. Visscher,Matthew R. Robinson,Matthew R. Robinson,Matthew R. Robinson +13 more
TL;DR: An improved method for trait prediction that makes use of genetic correlations between traits and apply it to summary statistics of psychiatric diseases is developed by Maier et al.
Journal ArticleDOI
Analysis of Rare, Exonic Variation amongst Subjects with Autism Spectrum Disorders and Population Controls
Li Liu,Aniko Sabo,Benjamin M. Neale,Benjamin M. Neale,Uma Nagaswamy,Christine Stevens,Elaine T. Lim,Elaine T. Lim,Corneliu A. Bodea,Donna M. Muzny,Jeffrey G. Reid,Eric Banks,Hillary Coon,Mark A. DePristo,Huyen Dinh,Tim Fennel,Jason Flannick,Stacey Gabriel,Kiran V. Garimella,Shannon Gross,Alicia Hawes,Lora Lewis,Vladimir Makarov,Jared Maguire,Irene Newsham,Ryan Poplin,Stephan Ripke,Stephan Ripke,Khalid Shakir,Kaitlin E. Samocha,Kaitlin E. Samocha,Yuanqing Wu,Eric Boerwinkle,Eric Boerwinkle,Joseph D. Buxbaum,Edwin H. Cook,Bernie Devlin,Gerard D. Schellenberg,James S. Sutcliffe,Mark J. Daly,Mark J. Daly,Richard A. Gibbs,Kathryn Roeder +42 more
TL;DR: Standard gene-based tests will require much larger samples of cases and controls before being effective for gene discovery, even for a disorder like ASD, according to results from whole-exome sequencing of 1,039 subjects diagnosed with autism spectrum disorders and 870 controls selected from the NIMH repository.
Journal ArticleDOI
Clozapine-induced agranulocytosis is associated with rare HLA-DQB1 and HLA-B alleles
Jacqueline I. Goldstein,L. Fredrik Jarskog,Chris Hilliard,Ana Alfirevic,Laramie E. Duncan,Denis Fourches,Hailiang Huang,Monkol Lek,Benjamin M. Neale,Stephan Ripke,Stephan Ripke,Kevin V. Shianna,Jin P. Szatkiewicz,Alexander Tropsha,Edwin J. C. G. van den Oord,Ingolf Cascorbi,Michael Dettling,Ephraim Gazit,Donald C. Goff,Arthur L Holden,Deanna L. Kelly,Anil K. Malhotra,Jimmi Nielsen,Munir Pirmohamed,Dan Rujescu,Thomas Werge,Deborah L. Levy,Richard C. Josiassen,James L. Kennedy,Jeffrey A. Lieberman,Mark J. Daly,Mark J. Daly,Patrick F. Sullivan +32 more
TL;DR: Two loci in the major histocompatibility complex are independently associated with clozapine-induced agranulocytosis/granulocytopenia (CIAG), and these associations dovetail with the roles of these genes in immunogenetic phenotypes and adverse drug responses for other medications, and provide insight into the pathophysiology of CIAG.
Journal ArticleDOI
Association study of common genetic variants and HIV-1 acquisition in 6,300 infected cases and 7,200 controls
Paul J. McLaren,Paul J. McLaren,Paul J. McLaren,Cédric Coulonges,Stephan Ripke,Stephan Ripke,Leonard H. van den Berg,Susan Buchbinder,Mary Carrington,Mary Carrington,Andrea Cossarizza,Judith Dalmau,Steven G. Deeks,Olivier Delaneau,Andrea De Luca,James J. Goedert,David W. Haas,Joshua T. Herbeck,Sekar Kathiresan,Sekar Kathiresan,Gregory D. Kirk,Olivier Lambotte,Olivier Lambotte,Ma Luo,Ma Luo,Simon Mallal,Daniëlle van Manen,Daniëlle van Manen,Javier Martinez-Picado,Laurence Meyer,José M. Miró,James I. Mullins,Niels Obel,Stephen J. O'Brien,Florencia Pereyra,Florencia Pereyra,Francis A. Plummer,Francis A. Plummer,Guido Poli,Ying Qi,Pierre Rucart,M. S. Sandhu,M. S. Sandhu,Patrick R. Shea,Hanneke Schuitemaker,Hanneke Schuitemaker,Ioannis Theodorou,Fredrik O. Vannberg,Jan H. Veldink,Bruce D. Walker,Bruce D. Walker,Amy C. Weintrob,Cheryl A. Winkler,Steven M. Wolinsky,Amalio Telenti,David Goldstein,Paul I.W. de Bakker,Paul I.W. de Bakker,Paul I.W. de Bakker,Jean-François Zagury,Jacques Fellay,Jacques Fellay +61 more
TL;DR: Analysis of genome-wide single nucleotide polymorphism data collected by 25 cohorts, studies, or institutions on HIV-1 infected individuals and compared them to carefully matched population-level data sets suggest that genetic influences on HIV acquisition are either rare or have smaller effects than can be detected by this sample size.
Journal ArticleDOI
High loading of polygenic risk for ADHD in children with comorbid aggression
Marian L. Hamshere,Kate Langley,Joanna Martin,Sharifah Shameem Agha,Evangelia Stergiakouli,Richard Anney,Jan Buitelaar,Stephen V. Faraone,Klaus-Peter Lesch,Benjamin M. Neale,Barbara Franke,Edmund J.S. Sonuga-Barke,Philip Asherson,Andrew Merwood,Jonna Kuntsi,Sarah E. Medland,Stephan Ripke,Hans-Christoph Steinhausen,Christine M. Freitag,Andreas Reif,Tobias J. Renner,Marcel Romanos,Jasmin Romanos,Andreas Warnke,Jobst Meyer,Haukur Palmason,Alejandro Arias Vasquez,Nanda Lambregts-Rommelse,Herbert Roeyers,Joseph Biederman,Alysa E. Doyle,Hakon Hakonarson,Aribert Rothenberger,Tobias Banaschewski,Robert D. Oades,J. J. McGough,Lindsey Kent,Nigel Williams,Michael John Owen,Peter Holmans,Michael Conlon O'Donovan,Anita Thapar +41 more
TL;DR: Common genetic variation is relevant to ADHD, especially in individuals with comorbid aggression, andPolygenic risk for ADHD, derived from the meta-analysis, was higher in the independent ADHD group than in the comparison group.