S
Suzanne Oparil
Researcher at University of Alabama at Birmingham
Publications - 941
Citations - 122414
Suzanne Oparil is an academic researcher from University of Alabama at Birmingham. The author has contributed to research in topics: Blood pressure & Angiotensin II. The author has an hindex of 106, co-authored 885 publications receiving 113983 citations. Previous affiliations of Suzanne Oparil include Michigan State University & Oregon Health & Science University.
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Journal ArticleDOI
Atrial Natriuretic Peptide Inhibits Transforming Growth Factor β–Induced Smad Signaling and Myofibroblast Transformation in Mouse Cardiac Fibroblasts
Peng Li,Dajun Wang,Jason Lucas,Suzanne Oparil,Dongqi Xing,Xu Cao,Lea Novak,Matthew B. Renfrow,Yiu-Fai Chen +8 more
TL;DR: Results suggest that phosphorylation of Smad3 by protein kinase G is a potential molecular mechanism by which activation of ANP/cGMP/protein Kinase G signaling disrupts TGF-β1–induced nuclear translocation of pSmad3 and downstream events, including myofibroblast transformation, proliferation, and expression of extracellular matrix molecules in cardiac fibroblasts.
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Treatment of hypertensive crisis.
David A. Calhoun,Suzanne Oparil +1 more
TL;DR: Improved management is essential to avoid catastrophic injury to the central nervous system, the heart, and the kidneys as a result of a delay in initiating effective therapy or of overzealous therapy leading to a too-rapid reduction in blood pressure.
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Hypertension in women.
Phyllis August,Suzanne Oparil +1 more
TL;DR: Investigations of gender differences in pathophysiology and response to treatment of essential hypertension have not been extensive, and current evidence does not support gender-specific treatment of hypertension at the present time.
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Importance of the renal nerves in established two-kidney, one clip Goldblatt hypertension.
TL;DR: The hypothesis that the afferent renal nerves contribute to the maintenance of hypertension in this model by modulating the activity of the sympathetic nervous system is supported.
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Diurnal Patterns and Regulation of Cortisol Secretion in Pregnancy
Wolfram E. Nolten,Marshall D. Lindheimer,Patricia A. Rueckert,Suzanne Oparil,Edward N. Ehrlich +4 more
TL;DR: Circadian cortisol patterns in pregnant and nonpregnant subjects were virtually identical, but total plasma cortisol was significantly higher in pregnancy, and calculated plasma biological half-lives and production rates of cortisol were increased significantly in gravidas.