S
Suzanne Oparil
Researcher at University of Alabama at Birmingham
Publications - 941
Citations - 122414
Suzanne Oparil is an academic researcher from University of Alabama at Birmingham. The author has contributed to research in topics: Blood pressure & Angiotensin II. The author has an hindex of 106, co-authored 885 publications receiving 113983 citations. Previous affiliations of Suzanne Oparil include Michigan State University & Oregon Health & Science University.
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Journal ArticleDOI
Phosphatidylinositol-3 Kinase Signaling Mediates Vascular Smooth Muscle Cell Expression of Periostin in Vivo and in Vitro
Guohong Li,Suzanne Oparil,John M. Sanders,Lin Zhang,Meiru Dai,Lan Bo Chen,Simon J. Conway,Coleen A. McNamara,Ian J. Sarembock +8 more
TL;DR: Upregulation of periostin expression in rat carotid arteries following balloon injury and in cultured VSMCs after stimulation by growth factors is mediated through PI-3-kinase-dependent signaling pathway.
Journal ArticleDOI
Stroke Reduction in Hypertensive Adults With Cardiac Hypertrophy Randomized to Losartan Versus Atenolol The Losartan Intervention For Endpoint Reduction in Hypertension Study
Jorge R. Kizer,Björn Dahlöf,Sverre E. Kjeldsen,Stevo Julius,Gareth Beevers,Ulf de Faire,Frej Fyhrquist,Hans Ibsen,Krister Kristianson,Ole Lederballe-Pedersen,Lars H Lindholm,Markku S. Nieminen,Per Omvik,Suzanne Oparil,Hans Wedel,Kristian Wachtell,Jonathan M. Edelman,Steven M. Snapinn,Katherine E. Harris,Richard B. Devereux +19 more
TL;DR: Substantial cerebrovascular benefit could be realized with the institution of losartan-based therapy over conventional therapy among hypertensive patients with left ventricular hypertrophy across the spectrum of cardiovascular risk.
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Estrogen Modulates NFκB Signaling by Enhancing IκBα Levels and Blocking p65 Binding at the Promoters of Inflammatory Genes via Estrogen Receptor-β
Dongqi Xing,Suzanne Oparil,Hao Yu,Kaizheng Gong,Kaizheng Gong,Wenguang Feng,Jonathan A Black,Yiu-Fai Chen,Susan Nozell +8 more
TL;DR: Data demonstrate that E2 inhibits inflammation in RASMCs by two distinct mechanisms: promoting new synthesis of IκBα, thus accelerating a negative feedback loop inNFκB signaling, and directly inhibiting binding of NFκB to the promoters of inflammatory genes.
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12-Month Blood Pressure Results of Catheter-Based Renal Artery Denervation for Resistant Hypertension: The SYMPLICITY HTN-3 Trial
George L. Bakris,Raymond R. Townsend,John M. Flack,Sandeep Brar,Sidney Cohen,Ralph B. D'Agostino,David E. Kandzari,Barry T. Katzen,Martin B. Leon,Laura Mauri,Manuela Negoita,William W. O'Neill,Suzanne Oparil,Krishna J. Rocha-Singh,Deepak L. Bhatt,Symplicity Htn Investigators +15 more
TL;DR: The results of the SYMPLICITY HTN-3 (Renal Denervation in Patients With Uncontrolled Hypertension) trial confirmed the safety but not the efficacy of renal denervation for treatment-resistant hypertension at 6 months post procedure as mentioned in this paper.
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Dominant negative mutation of the TGF-β receptor blocks hypoxia-induced pulmonary vascular remodeling
Yiu-Fai Chen,Ji-An Feng,Peng Li,Dongqi Xing,Yun Zhang,Rosa Serra,Namasivayam Ambalavanan,Erum Majid-Hassan,Suzanne Oparil +8 more
TL;DR: The hypothesis that endogenous TGF-beta plays an important role in pulmonary vascular adaptation to chronic hypoxia is supported and that disruption of T GF-beta signaling attenuates Hypoxia-induced pulmonary hypertension, right ventricular hypertrophy, pulmonary arterialhypertrophy and muscularization, alveolar remodeling, and expression of extracellular matrix mRNA in whole lung is supported.