T
Takao Sugiyama
Researcher at University of Tokyo
Publications - 68
Citations - 5401
Takao Sugiyama is an academic researcher from University of Tokyo. The author has contributed to research in topics: Allele frequency & Essential hypertension. The author has an hindex of 30, co-authored 68 publications receiving 5204 citations.
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Endothelin stimulates c-fos and c-myc expression and proliferation of vascular smooth muscle cells.
TL;DR: This work has shown that a potent vasoconstrictor peptide, endothelin (EDT), was isolated from vascular endothelial cells and stimulated the DNA synthesis of VSMCs in a dose‐dependent manner, which might be related to the development of atherosclerosis.
Journal ArticleDOI
Meta-analysis of genome-wide association studies identifies common variants associated with blood pressure variation in east Asians
Norihiro Kato,Fumihiko Takeuchi,Yasuharu Tabara,Tanika N. Kelly,Min Jin Go,Xueling Sim,Wan Ting Tay,Chien Hsiun Chen,Chien Hsiun Chen,Yi Zhang,Ken Yamamoto,Tomohiro Katsuya,Mitsuhiro Yokota,Young-Jin Kim,Rick Twee-Hee Ong,Toru Nabika,Dongfeng Gu,Li Ching Chang,Yoshihiro Kokubo,Wei Huang,Keizo Ohnaka,Yukio Yamori,Eitaro Nakashima,Cashell E. Jaquish,Jong-Young Lee,Mark Seielstad,Masato Isono,James E. Hixson,Yuan-Tsong Chen,Tetsuro Miki,Xueya Zhou,Takao Sugiyama,Jae Pil Jeon,Jianjun Liu,Ryoichi Takayanagi,Sung Soo Kim,Tin Aung,Tin Aung,Yun Ju Sung,Xuegong Zhang,Tien Yin Wong,Tien Yin Wong,Tien Yin Wong,Bok Ghee Han,Shotai Kobayashi,Toshio Ogihara,Dingliang Zhu,Naoharu Iwai,Jer-Yuarn Wu,Jer-Yuarn Wu,Yik Ying Teo,E. Shyong Tai,Yoon Shin Cho,Jiang He +53 more
TL;DR: A meta-analysis of genome-wide association studies of systolic (SBP) and diastolic (DBP) blood pressure in 19,608 subjects of east Asian ancestry followed up with de novo genotyping and further replication in east Asian samples provides new insights into blood pressure regulation and potential targets for intervention.
Journal ArticleDOI
Hemodynamic shear stress stimulates endothelin production by cultured endothelial cells
Masao Yoshizumi,Hiroki Kurihara,Takao Sugiyama,Fumimaro Takaku,Masashi Yanagisawa,Tomoh Masaki,Yoshio Yazaki +6 more
TL;DR: A possible role for hemodynamic shear stress in the regulation of endothelin production in vascular endothelial cells is suggested.
Journal ArticleDOI
Transforming growth factor-β stimulates the expression of endothelin mRNA by vascular endothelial cells
Hiroki Kurihara,Masao Yoshizumi,Takao Sugiyama,Fumimaro Takaku,Masashi Yanagisawa,Tomoh Masaki,Masaru Hamaoki,Hirohisa Kato,Yoshio Yazaki +8 more
TL;DR: Results suggest that TGF-beta 1, secreted by activated platelets, is involved not only in wound healing, but in the regulation of local vascular tone by stimulating endothelin production in the endothelial cells.
Journal ArticleDOI
Trans-ancestry genome-wide association study identifies 12 genetic loci influencing blood pressure and implicates a role for DNA methylation
Norihiro Kato,Marie Loh,Marie Loh,Marie Loh,Fumihiko Takeuchi,Niek Verweij,Xu Wang,Weihua Zhang,Tanika NKelly,Danish Saleheen,Danish Saleheen,Benjamin Lehne,Irene Mateo Leach,Alexander W. Drong,James Abbott,Simone Wahl,Sian Tsung Tan,William R. Scott,Gianluca Campanella,Marc Chadeau-Hyam,Uzma Afzal,Tarunveer S. Ahluwalia,Tarunveer S. Ahluwalia,Marc Jan Bonder,Peng Chen,Abbas Dehghan,Todd L. Edwards,Tõnu Esko,Min Jin Go,Sarah E. Harris,Jaana Hartiala,Silva Kasela,Anuradhani Kasturiratne,Chiea Chuen Khor,Marcus E. Kleber,Huaixing Li,Zuan Yu Mok,Masahiro Nakatochi,Nur Sabrina Sapari,Richa Saxena,Alexandre F.R. Stewart,Lisette Stolk,Yasuharu Tabara,Ai Ling Teh,Ying Wu,Jer-Yuarn Wu,Yi Zhang,Imke Aits,Alexessander Couto Alves,Shikta Das,Rajkumar Dorajoo,Jemma CHopewell,Yun Kyoung Kim,Robert WKoivula,Jian'an Luan,Leo-Pekka Lyytikäinen,Quang NNguyen,Mark A. Pereira,Iris Postmus,Olli TRaitakari,Molly Scannell Bryan,Robert A. Scott,Rossella Sorice,Vinicius Tragante,Michela Traglia,Jon White,Ken Yamamoto,Yonghong Zhang,Linda S. Adair,Alauddin Ahmed,Koichi Akiyama,Rasheed Asif,Tin Aung,Inês Barroso,Andrew Bjonnes,Timothy R. Braun,Hui Cai,Li Ching Chang,Chien Hsiun Chen,Ching-Yu Cheng,Yap Seng Chong,Yap Seng Chong,Rory Collins,Regina Courtney,Gail Davies,Graciela E. Delgado,Loi D. Do,Pieter A. Doevendans,Ron T. Gansevoort,Yu-Tang Gao,Tanja B. Grammer,Niels Grarup,Jagvir Grewal,Dongfeng Gu,Gurpreet SWander,Anna-Liisa Hartikainen,Stanley L. Hazen,Jing He,Chew-Kiat Heng,E. James Ames Hixso,Albert Hofman,Chris Hsu,Wei Huang,Lise Lotte N. Husemoen,Joo Yeon Hwang,Sahoko Ichihara,Michiya Igase,Masato Isono,Johanne Marie Justesen,Tomohiro Katsuya,Muhammad GKibriya,Young Jin Kim,Miyako Kishimoto,Woon-Puay Koh,Katsuhiko Kohara,Meena Kumari,Kenneth Kwek,Nanette R. Lee,Jeannette Lee,Jiemin Liao,Jiemin Liao,Wolfgang Lieb,David C. Liewald,Tatsuaki Matsubara,Yumi Matsushita,Thomas Meitinger,Evelin Mihailov,Lili Milani,Rebecca Mills,Nina Mononen,Martina Müller-Nurasyid,Toru Nabika,Eitaro Nakashima,Hong Kiat Ng,Kjell Nikus,Teresa Nutile,Takayoshi Ohkubo,Keizo Ohnaka,Sarah Parish,Lavinia Paternoster,Hao Peng,Annette Peters,Son TPham,M.J. Pinidiyapathirage,Mahfuzar Rahman,Hiromi Rakugi,Olov Rolandsson,Michelle Ann Rozario,Daniela Ruggiero,Cinzia Sala,Ralhan Sarju,Kazuro Shimokawa,Harold Snieder,Thomas Sparsø,Wilko Spiering,John M. Starr,David J. Stott,Daniel OStram,Takao Sugiyama,Silke Szymczak,W.H. Wilson Tang,Lin Tong,Stella Trompet,Väinö Turjanmaa,Hirotsugu Ueshima,André G. Uitterlinden,Satoshi Umemura,Marja Vääräsmäki,Rob M. van Dam,Wiek H. van Gilst,Dirk J. van Veldhuisen,Jorma Viikari,Melanie Waldenberger,Yiqin Wang,Aili Wang,Rory P. Wilson,Tien Yin Wong,Tien Yin Wong,Yong-Bing Xiang,Shuhei Yamaguchi,Xingwang Ye,Robin Young,Terri L. Young,Jian-Min Yuan,Xueya Zhou,Folkert W. Asselbergs,Folkert W. Asselbergs,Marina Ciullo,Robert Clarke,Panos Deloukas,Panos Deloukas,Andre Franke,W. Frank Paul,Steve Franks,Yechiel Friedlander,Myron D. Gross,Zhirong Guo,Torben Hansen,Marjo-Riitta Järvelin,Marjo-Riitta Järvelin,Torben Jørgensen,J. Wouter Jukema,Mika Kähönen,Hiroshi Kajio,Mika Kivimäki,Jong-Young Lee,Terho Lehtimäki,Allan Linneberg,Tetsuro Miki,Oluf Pedersen,Nilesh J. Samani,Thorkild I. A. Sørensen,Thorkild I. A. Sørensen,Ryoichi Takayanagi,Daniela Toniolo,Habibul Ahsan,Hooman Allayee,Yuan-Tsong Chen,John Danesh,John Danesh,Ian J. Deary,Oscar H. Franco,Lude Franke,Bastiaan THeijman,Joanna D. Holbrook,Aaron Isaacs,Bong Jo Kim,Xu Lin,Jianjun Liu,Winfried März,Andres Metspalu,Karen L. Mohlke,K. Sangher,Dharambir Harambir,Xiao-Ou Shu,Joyce B. J. van Meurs,Eranga N. Vithana,Ananda R. Wickremasinghe,Cisca Wijmenga,Bruce H W Wolffenbuttel,Mitsuhiro Yokota,Wei Zheng,Dingliang Zhu,Paolo Vineis,Soterios A. Kyrtopoulos,Jos C. S. Kleinjans,Mark I. McCarthy,Richie Soong,Christian Gieger,James Scott,Yik Ying Teo,Jiang He,Paul Elliott,E. Shyong Tai,Pim van der Harst,Jaspal S. Kooner,John C. Chambers +256 more
TL;DR: The trans-ancestry genome-wide association and replication study of blood pressure phenotypes among up to 320,251 individuals of East Asian, European and South Asian ancestry finds genetic variants at 12 new loci to be associated with blood pressure, providing new evidence for the role of DNA methylation in blood pressure regulation.