Thomas Foltynie

TL;DR: These data provide the most comprehensive survey of genetic risk within Parkinson's disease to date, providing a biological context for these risk factors, and showing that a considerable genetic component of this disease remains unidentified.

TL;DR: This work uses a BCI to interpret pathological brain activity in patients with advanced Parkinson disease and to use this feedback to control when therapeutic deep brain stimulation (DBS) is delivered to improve on both the efficacy and efficiency of conventional continuous DBS.

TL;DR: This work clarifies the profile of cognitive dysfunction in early PD and demonstrates that the dementing process in this illness is heralded by both postural and gait dysfunction and cognitive deficits with a posterior cortical basis, reflecting probable non-dopaminergic cortical Lewy body pathology.

TL;DR: The work suggests that the dementing process in Parkinson's disease is predictable and related to tau while frontal-executive dysfunction evolves independently with a more dopaminergic basis and better prognosis.

TL;DR: The pattern of cognitive deficits seen among patients using the Mini-Mental State Examination, a pattern recognition task, and the Tower of London task suggests that sub-groups of patients based on cognitive ability might be identifiable even in the early stages of disease, which may reflect regional differences in the underlying neuropathological processes.